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Democratic congresswomen sat down for interview with Gayle King, where Ocasio-Cortez condemned Republicans for not standing up to Trump

2.35pm BST

MSNBC’s Morning Joe revealed old footage Wednesday morning of Donald Trump partying with accused human trafficker Jeffrey Epstein that’s sure to dial up the cringe factor on your day.

Morning Joe dug up footage of Trump partying with Jeffrey Epstein at Mar-a-Lago in 1992 pic.twitter.com/3T4l2enrqc

Wow. Trump can be seen getting handsy with women in this footage of him partying with Epstein at Mar-a-Lago. pic.twitter.com/xhRaaDKLL3

2.14pm BST

Presidential candidate and California senator Kamala Harris swiped back at Trump for his remarks about the Democratic congresswomen late on CNN Tuesday, saying that the president “needs to go back where he came from and leave that office.”

Harris said also called the comments “un-American” and “unbecoming of the President of the United States.”

”I think it defiles the office of the United States,” Harris said. “It is irresponsible. It is hateful. It is hurtful. And he has taken the presidency to a new low.” -Kamala Harris

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Statistics are a blow to country’s biggest pharmaceuticals that paid millions of dollars in out of court settlements

Drug makers and distributors flooded the US with more than 75bn opioid pills in the crucial years when the country’s epidemic of painkiller addiction and deaths surged to record levels, according to previously secret data released by an American court.

The publication of the Drug Enforcement Administration statistics is a blow to some of the country’s biggest pharmaceutical firms that have paid hundreds of millions of dollars in out of court settlements in part to keep sealed evidence that they profiteered from escalating demand for opioids even as public health officials were declaring an epidemic.

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Sudan's ruling military and the pro-democracy movement signed a political document on Wednesday which is part of a power-sharing deal meant to end the country's deadlock after weeks of stalled talks. The signing comes after months of street protests and violence after the military ousted the dictator Omar al-Bashir

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Attack on restaurant in Iraqi Kurdish capital of Irbil leaves at least one dead

Gunmen have killed at least one Turkish diplomat in the capital of Iraqi Kurdistan, in an attack on consulate staff gathered in a restaurant, Turkey’s foreign ministry said.

The state-run Iraqi news agency identified the dead man as the deputy consul general, the Associated Press reported.

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Search engine’s decision follows pressure from campaign groups and MPs

Google has suspended the secondary ticketing company Viagogo from its paid-for global search rankings, with immediate effect, in what could prove a huge blow to the controversial website’s ability to do business.

The search engine giant’s surprise decision, in the face of pressure from campaign groups and MPs, comes with Viagogo also facing legal action from the Competition and Markets Authority.

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Cross-party inquiry finds people from African countries often perceive reasons given for failed applications as biased or discriminatory

British MPs have warned that the UK visitor visa system is “broken” and doing “severe damage” to UK-Africa relations.

The problems faced by experts trying to visit the UK are so widespread that many Africans believe the Home Office to be prejudiced against them and deliberately trying to reduce visitor numbers.

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Prosecutors say airline knew of problems with Airbus A330 plane that crashed, killing 228 people

French prosecutors have recommended that Air France face trial for manslaughter and negligence over the 2009 crash of a flight from Rio de Janeiro to Paris in which 228 people died.

Prosecutors concluded that Air France was aware of technical problems with a key speed-measuring instrument on its Airbus A330 plane, but had failed to inform or train pilots on how to resolve the issue, according to an investigation document seen by Agence France-Presse.

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Aaron McKenzie, 25, appears in court accused of murder of heavily pregnant woman

The former partner of a heavily pregnant woman who was stabbed to death in her own home has accepted responsibility for her killing, a court has heard.

On Wednesday, Aaron McKenzie, 25, appeared at the Old Bailey charged with the murder of Kelly Mary Fauvrelle, 26, who was eight months pregnant.

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Investigation into possible anti-competitive behaviour is likely to spark US anger

The European Union has launched a formal investigation into Amazon, opening a new front against US tech giants.

Announcing the decision, the European commissioner for competition, Margrethe Vestager, said she wanted to take “a very close look” at whether Amazon’s business practices broke EU anti-trust rules.

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Chancellor rubbishes claim by Boris Johnson ally that no-deal exit could boost economy by £80bn

Philip Hammond, the chancellor, has said it is “terrifying” that one of Boris Johnson’s close allies, Jacob Rees-Mogg, believes a no-deal Brexit will boost the economy.

The chancellor, who is expected to exit the government next week, expressed his horror after Rees-Mogg used a Daily Telegraph opinion piece to dismiss the “pure silliness” of Treasury forecasts suggesting a £90bn hit to the economy.

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