Sigma receptors are proteins found on mainly the surface of endoplasmic reticulum (ER) in certain cells. Sigma-1 and sigma-2 are the two main classes of these receptors. The sigma-1 receptor is involved neurological disorders and certain types of cancer. To understand better how the receptor is involved in disease and whether drugs developed to target it are working, it is important to be able to accurately trace the sigma-1 receptor. Researchers have now developed a probe, which can identify and latch onto the sigma-1 receptor.
Scientists went looking for preserved collagen, the protein in bone and skin, in dinosaur fossils. They didn't find the protein, but they did find huge colonies of modern bacteria living inside the dinosaur bones.
Within hours after fertilization, a unique genome forms from chromosomes contributed by the egg and sperm. However, this new genome is initially inactive and must be 'awakened' to begin the transcription of its DNA and start embryonic development. How life's first step happens has long fascinated developmental biologists.
Scientists developed a microrobot that can precisely transplant stem cells in various in vivo and vitro environments. Expects to improve the efficiency of treating degenerative neural disorders such as Alzheimer by accurately and safely delivering to a desired location.
A research team has investigated the transport mechanism of a bacterial membrane protein using an artificially produced antibody fragment. The transport proteins, called ABC exporters, are present, for instance, in the cell membranes of bacteria and in large quantities in cancer cells and are responsible for transporting small molecules out of the cells. Some transporters can pump antibiotics or chemotherapy agents out of the cells, thus rendering therapies ineffective. In the current study, researchers showed how the transport mechanism can be blocked.
Researchers have filled two knowledge gaps: The vacuoles of plant cells can be excited and the TPC1 ion channel is involved in this process. The function of this channel, which is also found in humans, has been a mystery so far.
Despite how essential plants are for life on Earth, little is known about how parts of plant cells orchestrate growth and greening. By creating mutant plants, researchers have uncovered a cellular communication pathway sought by scientists for decades.