New research shows how the drug QNZ-46 can help to lessen the effects of excess release of glutamate in the brain -- the main cause of brain injury in stroke. As stroke is the second leading cause of disability and early death in the UK, this study could offer hope to thousands of people at risk.
To understand the link between aging and neurodegenerative disorders such as Alzheimer's disease, scientists compared the genetic clocks that tick during the lives of normal and mutant flies. They found that altering the activity of a gene called Cdk5 appeared to make the clocks run faster than normal, and the flies older than their chronological age. This caused the flies to have problems walking or flying later in life, to show signs of neurodegeneration, and to die earlier.
Some see acupuncture as a safe alternative to drugs, while others argue there's no convincing evidence of clinical benefit and potential for harm. So should doctors recommend acupuncture for pain? Experts debate the issue.
Scientists used advanced imaging techniques to ascertain the resting state of an acid-sensing ion channel. Acid-sensing ion channels are believed to play a role in pain sensation as well as psychiatric disorders. Scientists expect the basic science research will spur new research and development into therapeutic agents targeting the channel.
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