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New study analyzed 2 million birth records and 3,000 cancer registry records and found that children born to obese mothers were 57% more likely to develop cancer, independent of other factors. This finding offers a rare opportunity for childhood cancer prevention.
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In a landmark study, scientists discovered what makes white blood cell counts spike in individuals who have high cholesterol, possibly leading to new therapies for heart disease. They looked at hypercholesterolemia, which is the type of high cholesterol that causes very high levels of LDL -- the so-called 'bad' cholesterol -- to circulate in the blood. They identified a new regulatory mechanism in zebrafish models responsible for this increase.
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Researchers describe how prostate cancer cells develop the ability to mimic bone-forming cells called osteoblasts, enabling them to proliferate in the bone microenvironment.
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Researchers have discovered a mechanism of drug resistance to Venetoclax®, also known as ABT-199, a BCL-2 targeting drug commonly used to treat chronic lymphocytic leukemia and acute myeloid leukemia. Their findings also suggest a possible co-treatment strategy to overcome this resistance.
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A subpopulation of bone cells releases factors that can halt the growth of breast cancer that's traveled to the bone, putting the cells in stasis.
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New findings about an aggressive form of leukemia could aid the development of novel drugs to treat the condition.
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Researchers tested to see if arsenic trioxide (ATO) was effective in combination with all-trans retinoic acid (ATRA) in in both the mouse model of acute myeloid leukemia (AML) and in human AML cells in the lab, and determined that the combination proved 'powerfully and exquisitely effective' against a subset of AML. The combo could serve as the foothold researchers need to overcome resistance to therapy -- a common challenge in treating AML.
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Clinical study treating BPDCN with tagraxofusp led to first FDA approval for the disease.
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Researchers have defined the roles of various cells in the bone marrow that are thought to control the fate of the nearly half million blood cells that develop there each day.
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Many people fighting a very aggressive form of acute myeloid leukemia (AML) don't survive more than five years. These very sick patients are often unable to receive the only cure -- a bone marrow transplant. Now, an international team of scientists report on a long-overlooked part of a leukemic cell's internal machinery, where they may have found a key to treating the aggressive blood cancer.
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