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I am having trouble understanding this. Say I have an alanine and a valine. According to resources, these are both small. But valine has more carbons than alanine, and it looks big to me. Thus, woulnt the folding be disrupted?

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So I'm currently reading the paper: Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099720/

They're combining ATAC-Seq with CRISPR perbutation. So they not only measure ATAC-Seq peaks, but also sgRNA. What I really do not understand is what information the sgRNA measurement gives. Why would I ever measure sgRNA?

submitted by /u/Zethsc2
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I’m going into my fourth year biochemistry program in New York. Going for a PhD in either Biochem or pharmacology, depending on which grad school I attend. I want to work in drug development/research in the future, so I would like to get my hand in industry experience.

I’ve been a research assistant in anesthesiology since my freshman year, but it is with my university instead of a company. I’ve searched on small company websites with the hopes of something being available for the future, but their websites tend to only show the lead executives, or very general “contact us” pages. Should I attempt to cold contact people in managerial positions (albeit it seems to be difficult, I’ll try and find a way lol), or should I attempt to use the “contact us” page? Is there another route I should try and take? Thanks all :)

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Basically just that. I'm finished with my Biochem class and am studying further for MCAT's, but I was just struck by how the AUG codon is both for Methionine and a start codon. How can starting every polypeptide with Methionine be advantageous? I assume it *must* be advantageous because of the 64 possible 3 unit combos for codons and only 1 codes for methionine and is a start codon. There must be a reason this evolved that way. Does anyone have ideas/answers? Or is it just a freak coincidence that had no negative impact so it continued that way?

submitted by /u/HugeHunter
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Title.

Thanks.

submitted by /u/Long_D_Shlong
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Hi all.

I'm a transfer student who got accepted to UCSD. I applied under environmental science but I'm switching to biochemistry.

I just wanted to know if biochemistry can lead into environmental science or something relating to it. Can biotechnology also lead into environmental work?

submitted by /u/daftrax
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I think Citicoline can have the potential to elicit a neurodegenerative disease in the future, if you supplement it when you are under the age of 25. Why, because the mechanism of action is that it increases glycophospholipids metabolism in the brain, that enhances membrane fluidity and permeability. This is good for someone suffering from senility or senescence but not for already healthy young adult. It will be the equivalent of too much of a good thing because, there is no reason for a young person to need too much phospholipids. This can manifest itself in a dangerous state where it can alter certain pathways that can harm a young developing brain. What are your guy's thoughts? Should this supplement be taken off the shelves so young people can't have access to it? Thank you.

submitted by /u/Iambadass1224
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(USA)

I am a biochemistry major from a good California school. I had originally planned on going to medical school, but freshmen year, I got in trouble for drug use for a serious drug (going through puberty I developed mental health problems in addition to traumas I experienced that I would rather not talk about). Instead of the school helping me, they got me in trouble. I have a 3.91GPA, 1.5k lab research hours and will be getting paid for my researchwork starting June 24th. I have also presented at numerous symposiums both undergraduate, and symposiums with gradate and post docs. I have all the stats to garauntee my entry to a decent medical school, and have a fair shot at a good medical school (lots of extracurricular aside from research).

I am still going to apply, because this is my dream and I need closure, but I know I will not get in. I will now have a bachelors degree in biochemistry and am unsure of what to do with it. Could I go to graduate school for chemical engineering, or just chemistry, or bioengineering? Do I try to get an intro biochem job at some pharma/biotech company with my bachelors for now? I would like to get a job in industry and have good pay, and live a financially secure life. Should I just go back to school for engineering after a couple years, as I know I would like engineering as much as biochemistry, and I have done well in classes in all subjects, which makes me think I could succeed in engineering.

I know that I messed up big time, I have fixed all the problems that I had, I just wish I was able to fix things before it cost me my dream. Thanks guys and gals =[

Best,

Ellipse

EDIT: Just to clarify, it was not legal trouble, but trouble with the school.

EDIT2: Thank you all for your support, it means a lot to me.

submitted by /u/tangentialellipse
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I'm a biochemistry major, and I'm looking for part-time jobs that are related to research, or just science in general that I could gain experience from. Besides lab technician, what are other jobs that are worth considering?

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Hey people, a biochemistry noob here and I really don’t get the D L (capital)and the d l(small) thing

submitted by /u/Weeza50
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