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The goal of this initiative is to support the identification, validation and manipulation of neural circuits that underlie cognitive, emotional, and social processes impacted in mental illnesses. The initiative is focused on probing psychiatrically relevant behavior through studies in non-human primates. This initiative is intended to complement existing NIMH-funded preclinical investigation of circuits which have often focused on smaller brains.
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The goal of this initiative is to support grant applications in two related but distinct areas. The first area involves developing and testing novel tools and methods of neuromodulation that go beyond the existing forms of neural stimulation. The second area involves the optimization of existing stimulation methods.
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The goal of the NCDDG Program is to advance the discovery, preclinical development, and early proof of concept testing in humans of new pharmacologic and neuromodulatory approaches to treat mental disorders, substance use disorders (SUDs), or alcohol addiction, and to develop novel ligands and circuit-engagement devices as tools to further characterize existing or to validate new drug/device targets.
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The goal of this BRAIN Initiative is to stimulate basic research to develop next-generation human cell-derived assays, including those involving human induced pluripotent stem cells (hiPSCs), with improved fidelity to complex human brain, spinal cord, and/or sensory end organ circuit physiology, particularly with respect to developmental trajectories.
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One of the goals of this concept is to increase the number of marmosets that are available to the neuroscience research community. The second major goal of this concept is to continue the development of the tools and technologies for transgenic manipulation and characterization of marmosets.
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The purpose of the Conte Centers program is to support interdisciplinary teams of researchers engaged in novel, creative, and integrated experimental approaches to address high-risk, high-impact scientific questions in either basic neuroscience research or in translational research that will significantly advance the state of the science in brain and behavioral research to ultimately provide the foundation for understanding mental disorders and/or transform the understanding and treatment of mental illnesses, as well as developing data and other research resources that are available to the scientific community to further advance research in this field.
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The goal of this initiative is to support the collection and genomic characterization of cohorts with severe mental illness from diverse ancestral backgrounds. The focus of this initiative will be the collection of large patient cohorts of non-Caucasian or admixed ancestries in the U.S. and around the globe. Study designs using case-control, parent-offspring trios, nuclear families or a combination thereof will be supported.
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The goal of this initiative is to encourage researchers to utilize invasive neural recording opportunities in humans to study the neural circuity underlying mental health disorders.
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This concept proposes to establish a network of academic and community sites that can rapidly recruit well-characterized cohorts of help-seeking individuals who meet criteria for “clinical high risk” (CHR) for psychosis. The multi-site network will conduct collaborative studies to test and validate biological measures and prediction algorithms to support experimental medicine trials involving CHR participants.
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The goal of this initiative is to encourage the development of novel radioligands for positron emission tomography (PET) or single photon emission computed tomography (SPECT) imaging to study the pathophysiology and treatment of brain disorders.
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