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Nature Chemistry, Published online: 20 May 2019; doi:10.1038/s41557-019-0266-1

Natural hydrogenases exclusively utilize Ni and/or Fe to activate or produce hydrogen. Now, a catalytically active [Mn]-hydrogenase has been prepared by incorporating a synthetic Mn complex into the apoenzyme of [Fe]-Hydrogenase. The semi-synthetic [Mn]-hydrogenase shows higher activity than the corresponding Fe analogue.
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Nature Chemistry by Hae Sung Cho, Jingjing Yang, Xuan G.. - 1w ago

Isotherms of individual pores by gas adsorption crystallography

Nature Chemistry, Published online: 13 May 2019; doi:10.1038/s41557-019-0257-2

Gas sorption studies in porous materials typically reflect their overall gas uptake. Now, using a ‘gas adsorption crystallography’ method, the gas adsorption isotherms of two metal–organic frameworks (MOFs) have been quantitatively decomposed into sub-isotherms that reflect the pore-filling behaviour of various guests in the different types of pores present in the MOFs.
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Unravelling mechanistic features of organocatalysis with in situ modifications at the secondary sphere

Nature Chemistry, Published online: 13 May 2019; doi:10.1038/s41557-019-0258-1

Secondary-sphere interactions serve a fundamental role in controlling the reactivity and selectivity of organometallic and enzyme catalysts, but their study in organocatalytic systems is scarce. Now, it has been shown that the in situ secondary-sphere modification of organocatalysts combined with machine-learning techniques can uncover reaction mechanisms and streamline catalyst optimization.
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Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis

Nature Chemistry, Published online: 13 May 2019; doi:10.1038/s41557-019-0261-6

A set of stereochemically complex and structurally diverse compounds were created from the diterpene natural product pleuromutilin using the complexity-to-diversity strategy. Phenotypic screening identified a compound that induces rapid ferroptotic death of cancer cells. Experiments to probe the mechanism revealed the compound to be an inhibitor of thioredoxin.
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Imaging defects and their evolution in a metal–organic framework at sub-unit-cell resolution

Nature Chemistry, Published online: 13 May 2019; doi:10.1038/s41557-019-0263-4

Structural defects are known to exist in metal–organic frameworks (MOFs), and to affect the materials’ properties, but their exact structures have remained difficult to determine. Now, missing-linker and missing-cluster defects have been observed in a MOF using low-dose transmission electron microscopy, enabling their distributions, evolutions during crystallization and effects on the material’s catalytic activity to be explored.
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Nature Chemistry by Tatiana Cañeque, Raphaël Rodriguez - 1w ago

Diverse engineering

Nature Chemistry, Published online: 13 May 2019; doi:10.1038/s41557-019-0269-y

Methods for generating molecular diversity provide a route to screen a wider section of chemical space, to discover compounds with useful biological properties. Now, a complexity-to-diversity strategy has enabled the discovery of a multi-cyclic structure from a complex natural product that induces ferroptotic cell death in cancer cells.
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Reaction blockading in a reaction between an excited atom and a charged molecule at low collision energy

Reaction blockading in a reaction between an excited atom and a charged molecule at low collision energy, Published online: 06 May 2019; doi:10.1038/s41557-019-0264-3

The reaction between an excited atom and a charged molecule has now been studied at low temperature and a reaction blockading effect has been observed that differs significantly from what is expected from standard chemical capture theory.
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Publisher Correction: Roaming-mediated ultrafast isomerization of geminal tri-bromides in the gas and liquid phases

Publisher Correction: Roaming-mediated ultrafast isomerization of geminal tri-bromides in the gas and liquid phases, Published online: 25 April 2019; doi:10.1038/s41557-019-0270-5

Publisher Correction: Roaming-mediated ultrafast isomerization of geminal tri-bromides in the gas and liquid phases
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Nature Chemistry by Craig P. Johnston - 3w ago

Safe, sustainable and scalable

Safe, sustainable and scalable, Published online: 24 April 2019; doi:10.1038/s41557-019-0262-5

Two recent back-to-back meetings conveyed a common set of ongoing challenges for the fields of organocatalysis, photoredox catalysis and photochemistry.
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Nature Chemistry by Bruce C. Gibb - 3w ago

Plastics are forever

Plastics are forever, Published online: 24 April 2019; doi:10.1038/s41557-019-0260-7

Bruce C. Gibb explains why plastic isn’t always fantastic.
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