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Revre CBD by Clay Hooten - 1M ago

Can CBD Cause Liver Damage?
Part 4 of our CBD Beyond The Hype series

Yesterday we ran across a Forbes article with a very concerning headline Marijuana Study Finds CBD Can Cause Liver Damage.  We were particularly interested in this story because we haven’t seen a study that said anything overly concerning about the safety of CBD. In fact, The World Health Organization has expressed very little concern about the safety of CBD. We discussed this in our Part 2 blog a few weeks ago.  

What Did The Article Conclude?

“Researchers at the University of Arkansas for Medical Science recently rolled up their sleeves to investigate CBD hepatotoxicity in mice. What they found was while this cannabis derivative is gaining significant recognition as of late in the world of wellness, people that use CBD are at an elevated risk for liver toxicity.”

How Does Dosage in the Study Compare to Industry Norms?

The article then compared this study to the maximum dosage for Epidiolex (FDA approved drug for epilepsy) which is 20 mg/kg of weight. This dosage is very misleading on its own because this maximum dosage is already very extreme compared to industry norms. If you weigh 150 pounds, the maximum daily dosage of Epidiolex would be 1,360 mg.  This is almost four bottles in one day of what is expected to be a monthly supply of CBD from most manufacturers. 17 mg is a daily dose for a 500 mg bottle of CBD.  

How Much CBD Caused This Extreme Result?

This was a study with mice, and the dosages that I am disclosing are the human doses not the MED or “mice equivalent”. The article went on to say that the mice that were given higher doses of CBD “had either died or were on the verge of death within a few days.” I looked at the study and found that “high doses” were not based on the maximum daily dosage of 20mg/kg of weight like Epidiolex, they were far greater.  

How High Were The Doses?

So how high were “higher doses”? 100 mg/kg? 150 mg/kg? 300 mg/kg? The highest dose in the study was actually 2,460 mg/kg. Given our prior example of the 150 pound person, this would equate to 167,280 mg of CBD. That is 334 bottles of 500 mg/bottle CBD.  

Did The Study Offer Any Conclusions on Safe Dosage?

What is even more egregious about the article is that the study did state that liver toxicity was not shown at what would be considered extremely high dosage. Of course, this was not included in the article.  

“No measurable toxicological responses associated with liver injury were observed in mice gavaged with CBD at 184.5 mg/kg (MED of 15 mg/kg CBD) or lower”.

This is a massive dose of CBD and not even remotely equivalent to normal dosages of ~17 mg to ~30 mg that is being recommended by most manufacturers.

To be fair, Epidiolex does have a warning for elevated liver enzymes. The FDA approved the drug despite 5%-20% of patients seeing elevated liver enzymes. The recommended daily dosage for Epidiolex is 5 mg/kg per day.  Using our 150 pound person equivalent, that is 340 mg per day which is a very large dose.

There is no question that additional studies will be helpful in educating consumers about CBD, unfortunately this is not one of them. Water can kill you if you ingest more than 1 liter per hour, hyponatremia.  

This article reminds me why we title our blog “Beyond The Hype”. This article is not only misleading, it is grossly misleading and should not have been published with its intended alarm.

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4347 W. NW Hwy.
Suite 130
Dallas, TX 75220

hello@revrecbd.com
214-282-2525

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Disclaimer

Statements on this website have not been evaluated by the Food and Drug Administration (FDA). Our products are not intended to diagnose, treat, cure or prevent any disease. This product is not for use by or sale to persons under the age of 18. This product should be used only as directed on the label. It should not be used if you are pregnant or nursing. This website is not offering medical advice. Consult with a physician before use if you have a serious medical condition or use prescription medications. A Doctor's advice should be sought before using this and any supplemental dietary product. By using this site, you agree to follow the Privacy Policy and all Terms & Conditions printed on this site. CBD rich hemp oil extracted from the stalks of mature industrial hemp is federally legal. Revre CBD assumes no responsibility for any legal charges as a result of changing local/state laws. It is buyer’s responsibility to determine if any transaction from RevreCBD.com and its affiliates is in violation with local rules and regulations.

The post Can CBD Cause Liver Damage? appeared first on Revre CBD.

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Revre CBD by Clay Hooten - 1M ago

Hemp is now legal in Texas!
Part 3 of our CBD Beyond The Hype series

On Monday, June 10, Governor Greg Abbott of Texas signed hemp legislation making hemp production legal in Texas. Texas is likely to be a large producer of hemp in the future which adds an additional vehicle for growth to an already strong and surging economy. It’s especially exciting for us here at Revre, being proudly based in Texas.

CBD users in Texas can now feel comfortable that they will not be hassled by law enforcement for use of a product that is already legal at the federal level. The law clarifies that CBD with up to .3% THC is now legal in Texas. Previously, Texas was a zero THC state. This will allow potential users to enter the market without the fear of committing a crime. Additionally, TSA has recently ruled that you can travel with CBD (see our recent post on this topic).  

It’s an exciting time for hemp in the US, creating new opportunities for growers, consumers and the economy as a whole. And they always say — a rising tide raises all ships.

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Revre CBD LLC
4347 W. NW Hwy.
Suite 130
Dallas, TX 75220

hello@revrecbd.com
214-282-2525

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Disclaimer

Statements on this website have not been evaluated by the Food and Drug Administration (FDA). Our products are not intended to diagnose, treat, cure or prevent any disease. This product is not for use by or sale to persons under the age of 18. This product should be used only as directed on the label. It should not be used if you are pregnant or nursing. This website is not offering medical advice. Consult with a physician before use if you have a serious medical condition or use prescription medications. A Doctor's advice should be sought before using this and any supplemental dietary product. By using this site, you agree to follow the Privacy Policy and all Terms & Conditions printed on this site. CBD rich hemp oil extracted from the stalks of mature industrial hemp is federally legal. Revre CBD assumes no responsibility for any legal charges as a result of changing local/state laws. It is buyer’s responsibility to determine if any transaction from RevreCBD.com and its affiliates is in violation with local rules and regulations.

The post Hemp is now legal in Texas! appeared first on Revre CBD.

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Is CBD Safe and Can it Help With Pain, Sleep and Anxiety?

Part 2 of our CBD Beyond The Hype series

Since Congress passed the 2018 Farm Bill (legalizing Hemp/CBD at the Federal level), consumers have been bombarded with information about the benefits and risks related to usage of CBD. We have seen many articles written about the lack of scientific proof that CBD works for its many touted benefits. Part of the “lack of proof” comes from the fact that the research in the US has been generally non existent for medical use of cannabis.

The Godfather of Medical Cannabis Research

Israel is where the majority of research on cannabis has taken place. It started with Raphael Mechoulam’s discovery of THC and its psychoactive properties in 1964 Mechoulam. Mechoulam and his team later discovered the endocannabinoid system (ECS) which is the largest receptor system in the human body. We know that THC impacts the CB1 and CB2 receptors to create the “high”, but we know less about how CBD works to help regulate our ECS. CBD is thought to have a broader impact on getting the body back to homeostasis by increasing our bodies own cannabinoids, binding with our serotonin receptors and stimulating receptors that help calm the nervous system. Dr. Yasmine Hurd (Mount Sinai in NY) said it well. “The brain is about a symphony” and CBD “brings the symphony into harmony” (NY Times- Can CBD Really Do All That?).

Israeli Study on Pain in Elderly

A recent study out of Israel looked at cannabis use with elderly patients for pain (Study). Patients were asked to rate their daily pain before and after 6 months of treatment. 93.7% of patients reported improvement in their condition and the reported pain level was reduced from an 8 to 4 (scale of 1-10, prior to and after 6 months of treatment). Conclusion: Our study finds that the therapeutic use of cannabis is safe and efficacious in the elderly population. Cannabis use may decrease the use of other prescription medicines, including opioids.

Study on Anxiety and Sleep

In January 2019, The Permanente Journal released results from a retroactive charts study of 72 psychiatric clinic patients who were prescribed CBD. 79% of the patients had improved anxiety scores during the first month that continued for the study period. Sleep scores improved in the first month for 66% of the patients (Study).

What Does The World Health Organization Say About Safety?

“In humans, CBD exhibits no effects indicative of any abuse or dependence potential”

“There is also preliminary evidence that CBD may be a useful treatment for a number of other medical conditions.”

“CBD is generally well tolerated with a good safety profile. Reported adverse effects may be as a result of drug-drug interactions between CBD and patients’ existing medications.”

CBD seems to have some positive relationship with our endocannabinoid system and while we do not fully understand exactly how they interact, there is some scientific evidence and significant anecdotal evidence to support potential health benefits. Since safety concerns are very low with CBD, it is not surprising that consumers are jumping on board before all of the evidence is proven.

External Links:  https://www.who.int/medicines/access/controlled-substances/CannabidiolCriticalReview.pdf

© 2019 Revre CBD
All Rights Reserved

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Revre CBD LLC
4347 W. NW Hwy.
Suite 130
Dallas, TX 75220

hello@revrecbd.com
214-282-2525

Returns

Disclaimer

Statements on this website have not been evaluated by the Food and Drug Administration (FDA). Our products are not intended to diagnose, treat, cure or prevent any disease. This product is not for use by or sale to persons under the age of 18. This product should be used only as directed on the label. It should not be used if you are pregnant or nursing. This website is not offering medical advice. Consult with a physician before use if you have a serious medical condition or use prescription medications. A Doctor's advice should be sought before using this and any supplemental dietary product. By using this site, you agree to follow the Privacy Policy and all Terms & Conditions printed on this site. CBD rich hemp oil extracted from the stalks of mature industrial hemp is federally legal. Revre CBD assumes no responsibility for any legal charges as a result of changing local/state laws. It is buyer’s responsibility to determine if any transaction from RevreCBD.com and its affiliates is in violation with local rules and regulations.

The post Is CBD Safe and Can it Help With Pain, Sleep and Anxiety? appeared first on Revre CBD.

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CBD Beyond The Hype: Can I Travel By Plane with CBD Oil?

Hardly a day goes by that we do not see a lead story about CBD.  Many of these are misleading and the news cycle has turned from the benefits of CBD to more alarming and negative stories.  Recently, NBC ran a story on a grandmother getting arrested clearing customs at DFW Airport.  This is a most unfortunate circumstance and highlights the dangers of traveling with CBD.  It also highlights the need for states to legislate in accordance with the federal law that has now legalized hemp and CBD through the 2018 Farm Bill.  Fortunately, we are starting to see governing bodies clarify rules that will allow more freedom of use for CBD users.

Over the weekend, TSA clarified that CBD is now legal to carry on domestic flights as long as it is legally produced under the 2018 Farm Bill.  This is welcome news for travelers who use CBD daily. Please note that TSA currently has no way to test for levels of THC in CBD oil (testing).  While the TSA clarification has likely shifted the burden of proof from travelers, it still could pose problems with their ability to detect legal products vs illegal.  The 2018 Farm Bill made CBD oil legal as long as it is produced from a licensed grower and contains .3% THC or less. Law enforcement is unable to detect percentages of THC found in CBD oil which could make it difficult to differentiate a legal product from an illegal one.  Travelers could still be hassled until testing gets more sophisticated.

There are other factors to consider when traveling with CBD.  Some states are not yet on board with the 2018 Farm Bill. Texas has been one of those states due to its zero THC policies. Differences in federal vs state laws are causing significant confusion with consumers.  States are acting to offer clarity in the laws and their enforcement but it takes some time for states to catch up. The Texas congress has sent a bill to the Governor for hemp legislation to be passed which will allow hemp farming in Texas and make CBD products legal if they contain less than .3% THC.  

One additional factor that you need to pay attention to is testing.  Since almost all of the legal issues with CBD are related to THC, it is important to view third party lab results prior to making purchase decisions.  These should be available on the seller’s website. In addition to giving you piece of mind that you have a legal product, testing also provides verification of the cannabinoid(s) in the product.  Here is a sample report for you to view. This report is for a CBD isolate with zero THC.

© 2019 Revre CBD
All Rights Reserved

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Revre CBD LLC
4347 W. NW Hwy.
Suite 130
Dallas, TX 75220

hello@revrecbd.com
214-282-2525

Returns

Disclaimer

Statements on this website have not been evaluated by the Food and Drug Administration (FDA). Our products are not intended to diagnose, treat, cure or prevent any disease. This product is not for use by or sale to persons under the age of 18. This product should be used only as directed on the label. It should not be used if you are pregnant or nursing. This website is not offering medical advice. Consult with a physician before use if you have a serious medical condition or use prescription medications. A Doctor's advice should be sought before using this and any supplemental dietary product. By using this site, you agree to follow the Privacy Policy and all Terms & Conditions printed on this site. CBD rich hemp oil extracted from the stalks of mature industrial hemp is federally legal. Revre CBD assumes no responsibility for any legal charges as a result of changing local/state laws. It is buyer’s responsibility to determine if any transaction from RevreCBD.com and its affiliates is in violation with local rules and regulations.

The post CBD Beyond The Hype: Can I Travel By Plane with CBD Oil? appeared first on Revre CBD.

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