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Casey Willax Above: "I am just stoked to be apart of the Nanocraft team. As a pro snowboarder we abuse the heck out of our bodies day after day! It is like a precursor to my health, when I know its gonna be a long day of riding I use the products to prevent swelling and tone things down after a long hard day... The day formula is pretty bomb in coffee too"

It is no secret that athletes tend to physically abuse their bodies more than any other demographic, both positively and negatively. When it comes to training and sport specific activities, an athlete will increase human performance through endurance training, muscle loading and by increasing neuromuscular communication. However, athletes tend to overuse their bodies, often resulting in chronic pain, inflammation and career ending injuries.

Currently, athletes who are not totally informed will take traditional pain management routes, which often consist of bed rest, NSAIDS and opioids, until cleared for “return to play”. In more recent times, athletes have become smarter about how they treat their bodies and ultimately, what they put in them for performance and recovery purposes. Research and literature has recently begun to express the safety and efficacy on the use of cannabidiol (CBD) for pain and inflammation management and recovery.

It is nothing new to the industry that there is an opioid epidemic. Chronic use of over the counter medications pose a huge health risk and have shown to lead to addiction of harder pain management drugs that killed 52,404 U.S. citizens, including 33,091 (63.1%) that involved an opioid in 2015 and the numbers have only grown. There has been progress in preventing methadone deaths, and death rates declined by 9.1%. However, rates of deaths involving other opioids, specifically heroin and synthetic opioids other than methadone increased sharply overall and across many states in the U.S. Gladden et al., 2016, Peterson et al., 2016.

IS IT LEGAL?

Traditionally, no, but as of 2018 the world anti doping agency (WADA) and the US antI-doping agency removed CBD from the banned substance list, while the ban on THC still remains in effect, the threshold in which is considered tolerable was increased 10 fold, due to the fact that whole plant hemp derived CBD products can contain trace amounts of THC.

The only issue that athletes may currently face is that legislation regarding the usage of cannabis oil is constantly evolving, on the federal, state and local levels. This means that athletes in certain areas still may have some issues acquiring the product in their region, which still causes people to raise the question as to whether or not they should be purchasing and utilizing the product.

BASIC PROOFS

Athletes are now able to consume CBD products legally, but why? What will they use it for specifically?

In more recent years it has become evident that the bodies endocannabinoud system plays a significant role in modulating neuronal and immune system activity. Cannabidiol (CBD) is a phytocannabinoid found naturally in the cannabis plant. Unlike THC, which is also found in cannabis, CBD is not psychoactive and multiple studies have been conclusive in the fact that it can be used to treat ailments associated with inflammation and pain. Although the research is constantly evolving, the direction is pointing towards a new frontier in terms of holistic methods to treat pain and inflammation.

CB1 receptors are found throughout the brain, spinal cord, and other tissues. CB2 receptors are as well, but more often they are found throughout the immune system. CBD indirect interactions with CB1 receptors has a greater effect on the central nervous system, and CBD interacting with CB2 receptors has a greater effect on reducing inflammation and ultimately act to maintain homeostasis. As an athlete, often time neuromuscular communication is overused and CBD may act to facilitate recovery time at the cellular level.

Studies of animal models have identified that transdermal (topical CBD pain salves) applications of CBD allow for the accumulation within the skin and skeletal muscle by indirect action on cannabinoid receptors, which are identified as receptors of both the immune system and central nervous system and play a major role in cytokine release, an important step in the inflammatory process. A study conducted by Hammell et al., 2016 explained that results of a chemical analysis of the spinal cord revealed that dose dependent reductions in pro-inflammatory markers were seen within the spinal cord after administering topical CBD over four consecutive days.

 Data would suggest that transdermal CBD and edible (Tinctures) applications have therapeutic potential for relief of pain associated with acute and chronic inflammation without evident side effects. Although more research is needed to prove this application in humans, animal models have shown strong evidence to believe that CBD may indeed provide a very potent transdermal (topical) pain relief with anti-inflammatory properties.

Taylor Knox Below: "CBD has completely changed the game in terms of sports recovery. The opioid epidemic has destroyed careers and lives... Now that I am getting older, I am a father and still performing at a high level, I need to ensure that what I am putting in my body is going to actually improve my quality of life, and it does"

TOP 5 BENEFITS

PAIN X INFLAMMATION

Studies have shown cannabis is effective for reducing pain, including musculoskeletal pain from exercise, as well as stiff joints induced by exercise and sport (Halawa et al., 2018).

Despite the lack of conclusive amounts of evidence, due in part because of federal regulation disabling more research in the U.S, CBD does appear to relieve pain effectively for many athletes.

Inflammation can be good for athletes and help stimulate positive training adaptations. You can really look at inflammation as a good physiological response to a bad situation. Inflammation typically characterizes that the body is addressing trauma to the area, specifically muscle in athletes and facilitating growth (Hypertrophy). Too much inflammation hinders recovery and hurts performance. There are CB2 receptors in both the brain and periphery, but they are more concentrated in immune tissues. Cannabinoids interact with CB2 receptors, which seem to have an anti-inflammatory effect by reducing cytokine (cell messengers) production locally (Nagarkatti et al., 2019) In other words, CB2 receptors help dial down the response when your immune system sounds the alarm after intense bouts of physical activity.

Mason Ho Below: "Now that I am getting older I am way more in tune with my body. CBD has been a game changer and when the waves are on and I don't have it... Thats when I truly know how impactful it can be to my surfing"

CUT THE NSAIDs

Athletes traditionally consumed over-the-counter non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen (Advil) for decades. However, recent evidence has advocated for the dangers imposed on the Kidney’s when you consume them in excess. Long-term or frequent use of NSAIDs may also increase your risk for heart attack and stroke caused by embolism. Some athletes have found the pain relieving effect of CBD can reduce or eliminate their use of NSAIDS for exercise-related pain and no documented deaths from cannabis or cannabinoid-based products have ever been recoded.

CUT THE OPIOIDS

According to the CDC, in 2017 prescription medications were involved in more than 70,000 deaths in the US. Of those deaths 67.8% were Opioid pain medications (i.e. morphine, codeine, oxycontin). A significant increase since 2015 CDC statistics.

These drugs are highly effective for pain management, but have a significant risk involved in taking these drugs for any duration of time. Cannabinoids are not as effective as opioids for relieving acute, high-intensity pain, but may be effective for long-term pain management without any side and adverse affects associated with it.

CALM THE GUTS

Inflammation in the small and large intestines causes a lot of discomfort, and GI distress is one of the leading reasons endurance athletes drop out of races. CBD won’t solve stomach problems from dehydration and overheating, that's a different battle. Cannabidiol (CBD) appears to be a very promising compound because of the anti-inflammatory effects. Investigators have explained the results of a study that indicated CBD is a potent compound that is able to modulate gut inflammation through poorly understood mechanisms of action between the central nervous system and the gut, Filippis et al., 2011. This may have future implication that may enable future research to confirm these findings.

IMPROVE SLEEP

Currently around 25% of the American people experience sleeping issues such as insomnia. Additionally, research has shown that people with chronic insomnia are more likely to develop or have depression and vice versa.

Getting quality sleep is one of the most effective ways an athlete can achieve greater gains and is equally as important as the training itself. On an individual basis, athletes who consume CBD report improved sleep quality and duration. One potential reason for this could be CBD inhibiting the reuptake of adenosine. (Rodriguez et al., 2009)

Adenosine triphosphate (ATP, Body Fuel) breaks down as your body burns substrate (Protein, Fat, Carbs) for energy, and adenosine gradually accumulates in the brain. More adenosine binding to neurons inhibits the release of neurotransmitters, slowing down neuronal activity, helping you feel calmer, and inducing sleep.

By binding to same receptors adenosine would bind to, CBD may inhibit adenosine reuptake, which helps it accumulate more quickly and makes you feel tired. CBD may also have a potent anti-anxiety effect for some people, which can help them get to sleep and have more restful sleep by stabilizing cardiac rhythm during sleep.

Eli Olson Below: "Since coming onboard with Nanocraft CBD my sleeping patterns have improved. All my friends and family know how bad I struggle with insomnia. Often times I find myself going on runs at 3 AM because I can't sleep. The night and day formulas have been a game changer when I have those long days in the dojo and surfing... Recovery has been phenomenal"

THE HOW.

It seems as though everyday you wake up to discover some new way to ingest CBD. Whether it is soft gels, vapor pens, super-food powder, pain salves, tinctures and everything in between, there is a way for almost all demographics to get CBD into the body.

How you use it can also determine the potency and time in which the constituent actives the cannabinoids receptors. Vapor would essentially be the most immediate, due to the fact that once the cannabis diffuses through pulmonary capillaries and loads onto the red blood cells, it then  travels to the heart and up the carotid artery directly to the blood brain barrier enabling immediate and potent activation of the endocannabinoid system. However, it is still skeptical whether or not the product should be inhaled at all, due to the fact that putting anything in your lungs aside from air may have a negative impact on long-term health

Edibles have to be digested, so they may take a bit longer than vaping. CBD Topical creams may also be quicker than edibles, but often times it may take a couple applications to allow CBD to cross the dermal layers of the skin and sublingual drops/tinctures are said to be the most rapid aside from the vapor. 

CBD is now available in three different forms that are derived from many extraction methods. It is available in full spectrum, broad spectrum and isolate form. Full-spectrum allows extraction of the entire cannabis plant, which typically contains up to .3% THC (legally) and contains over 100 different phytocannbinoids which create that potent “entourage” effect. Broad spectrum, similar to full-spectrum CBD (whole plant) but does not contain any THC, making it a little less potent and enables athletes that undergo routine drug tests to still reap the benefits of CBD. Isolate is the final form and is characterized as being just pure extracted CBD up to 99.9% which has been said to have therapeutic benefits, but not to the extent of full spectrum and broad spectrum formulas.

HOW MUCH?

This part gets a little grey when it comes to prescribing a specific dose or giving recommendations. Currently, cannabis products are not regulated by the FDA therefore it is not very consistent when it comes to contents of the product and can be something that you really want to do your homework on before just committing to a cheap product. Plus, just like any other individual human response, not one recommendation is going to produce the same results.

Most CBD companies that sell tinctures bottle them in 30ml tincture bottles and the servings are geared towards 1ml/day, making each bottle about a months worth of servings, but again, this varies person to person and I have personally turned my months worth of servings into about 2-weeks for the benefits I am looking for.

FINAL THOUGHTS  

Although CBD has created a ton of buzz along with some interesting science and testimonials to back it, the biggest challenge in the industry currently faces is that there is still so much to learn about the science, formulations and delivery. Although CBD is removed from the banned substance list, there is still much caution for certain athletes due to the fear that a product may contain THC, when is says it does not. At this point, the benefits out weigh the risk and if it can steer people away from harder pharmaceuticals that have proven to be dangers then we can all rest a bit easier knowing that we are advocating a consuming a natural, plat derived product.

APPLICATIONS x CBD

New to CBD? check out the related link to the new user guide.

Cannabinoid options of application:

Transdermal (Skin)-Topical Salve: This application is typically used for acute and direct application. Such as an ankle sprain, arthritis, tendonitis, plantar fasciitis, carpal tunnel, tennis elbow, fibromyalgia and migraines. Full-spectrum salves provide a whole panel of cannabinoids for increased potency.

Edible Application

Tinctures: Tincture oils are utilized in full-spectrum form (whole plant derived) and Isolated forms (Pure CBD) that are applied directly under the tongue or mixed in water. This form is typically used for direct application to the central nervous system and the entire body for ailments like anxiety, stress, epilepsy, insomnia, depression, PTSD, autoimmune responses, ADHD, cancer, systemic inflammatory disease such as, cardiovascular disease, diabetes and metabolic syndrome. All applications are available as CBD isolate, broad spectrum and full spectrum.

Soft Gels: Full-spectrum soft gels essentially have the same application as tincture oils. The difference is that each soft gel is measured to a specific milligram to provide a consumer with a perfectly measured dose of CBD. This would be used for any ailments one might use CBD for, including all the ones listed above.

 Superfood powder: Super food green powder has a broad range of greens, phytonutrients, vitamins and of course CBD. This application is great to give some a nice, clean energy boost before a workout or just to get your day started naturally with improved focus.

 REFERENCES:

1.) Gladden RM, Martinez P, Seth P. Fentanyl law enforcement submissions and increases in synthetic opioid-involved overdose deaths—27 states, 2013–2014. MMWR Morb Mortal Wkly Rep 2016;65:837–43.

2.) Peterson AB, Gladden RM, Delcher C, et al. Increases in fentanyl-related overdose deaths—Florida and Ohio, 2013–2015. MMWR Morb Mortal Wkly Rep 2016;65:844–9. 

3.) Booz G. W. (2011). Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. Free radical biology & medicine, 51(5), 1054-61.

4.) Guindon J, Hohmann AG. Cannabinoid CB 2 receptors: A therapeutic target for the treatment of inflammatory and neuropathic pain. Br J Pharmacol2008;153(2):319–34.

5.) Hammell DC, Zhang LP, Ma F, et al. Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis. Eur J Pain (United Kingdom)2016;

6.) Halawa, Omar I., et al. “Role of Cannabinoids in Pain Management.” Essentials of Pain Medicine, 2018, doi:10.1016/b978-0-323-40196-8.00056-5.

7.) Nagarkatti, Prakash, et al. “Cannabinoids as Novel Anti-Inflammatory Drugs.” Future Medicinal Chemistry, vol. 1, no. 7, 2009, pp. 1333–1349., doi:10.4155/fmc.09.93.

 

 

 

 

 

 

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CANCER x STATS

Cancer has become a major public health concern in the United States and around the globe. It is estimated that one in four deaths in the US are due to cancer. Statistics from 2005 estimated that 1.4 million people were diagnosed with cancer that year and the estimated amount of deaths was just over half a million and the growth rate was projected to increase by 0.3% per year. In general, cancer can be characterized as neoplastic and is due to numerous cellular changes. Although all cancers are different, the common features underlying neoplasia (Tumor growth) is alterations in the cellular membrane. It has become apparent that these changes are caused by environmental factors like poor air quality, smoking tobacco, consuming excessive amounts of alcohol, poor work environments, poor diet and radiation exposure, Jemal et al., 2009.

CANCER x CBD

Cannabidiol (CBD) has been recognized as a major non-psychoactive constituent of cannabis that can be ingested or applied topically. Research has shown that cannabis possesses anti-neoplastic properties, meaning that it can inhibit or halt the development of cancerous tumors by initiating cell death, limiting inflammation, cell proliferation, and cell survival. In particular, emerging evidence suggests that cannabinoid receptors expressed by tumor cells may offer a healthier strategy to treat certain cancers, which may also depend on how aggressive it might be McAllister et al., 2011.

x LEUKEMIA x

Chronic lymphocytic leukemia (CLL)  is considered the most common form of leukemia in developed countries and is characterized by a rapid increase and accumulation of tumor encouraging B-lymphocytes in the blood, bone marrow, lymph nodes, and spleen, which are typically seen as markers for injury and illness. The typical age of diagnosis is 65 years, with only 10 to 15 percent under 50 years of age Rozman et al., 1995.  

Although all forms of leukemia share similarities such as excessive white blood cell production within the blood indicating a heightened immune response and cellular mutation and proliferation, each subtypes posses their own particular traits. 

Other forms of leukemia and their specific traits are listed as follows:

Acute lymphocytic leukemia (ALL), also called acute lymphoblastic leukemia and acute lymphoid leukemia, is a blood cancer that results when abnormal white blood cells (leukemia cells) accumulate in the bone marrow. It can occur at any age, but acute lymphocytic leukemia incidences occur most frequently in people under the age of 15 or over the age of 45. Although ALL makes up the largest percentage of leukemia diagnoses in children under the age of 15 (specifically between the ages of two to four), it is rare for adults to develop this disease.

Acute myeloid leukemia (AML), also known as acute myelogenous leukemia, acute myeloblastic leukemia, acute granulocytic leukemia or acute nonlymphocytic leukemia, is a fast-growing form of cancer of the blood and bone marrow. AML is the most common type of acute leukemia. It occurs when the bone marrow begins to make blasts, cells that have not yet completely matured. These blasts normally develop into white blood cells. However, in AML, these cells do not develop and are unable to ward off infections.

Chronic myeloid leukemia (CML), also known as chronic myelogenous leukemia, begins in the blood-forming cells of the bone marrow and then, over time, spreads to the blood. Eventually, the disease spreads to other areas of the body. It has been shown that CML is associated with an abnormal chromosome known as the Philadelphia chromosome (Ph chromosome). 

Chromosomes are structures in cells that contain genes, which give instructions to the cells. The Ph chromosome is an abnormality that occurs when a piece of chromosome 22 breaks off and attaches to the end of chromosome 9, which also breaks off and attaches to chromosome 22.The breaks in both chromosomes cause the BCR and ABL genes, which combine to create the cancer gene. The link between the Ph chromosome and CML was discovered around 1960.

Hairy cell leukemia (HCL) is a rare subtype of chronic lymphocytic leukemia (CLL) that progresses slowly. HCL is caused when bone marrow makes too many B cells (lymphocytes), a type of white blood cell that fights infection. As the number of leukemia cells increases, fewer healthy white blood cells, red blood cells and platelets are produced. HCL affects more men than women, and it occurs most commonly in middle-aged or older adults. HCL is considered a chronic disease because it may never completely disappear.

Myelodysplastic syndromes (MDS) are a group of closely related diseases in which the bone marrow produces too few functioning red blood cells (which carry oxygen), white blood cells (which fight infection), or platelets (which prevent or stop bleeding), or any combination of the three. The different types of myelodysplastic syndromes are diagnosed based on certain changes in the blood cells and bone marrow. The cells in the blood and bone marrow (also called myelo) usually look abnormal (or dysplastic), hence the name myelodysplastic syndromes.

According to the American Cancer Society, about 13,000 people a year are diagnosed with MDS. In the past, MDS was commonly referred to as a preleukemic condition (and it is still sometimes called preleukemia) because some people with MDS develop acute leukemia as a complication of the disease. However, most patients with MDS will never develop acute leukemia.

LEUKEMIA x CBD

A study published in the journal of molecular pharmacology examined the effects of  cannabidiol (CBD), on the induction of cellular death in leukemic cells. Exposure of leukemia cells to CBD oil led to reductions in cell viability and induction in cellular death (Apoptosis). Furthermore, CBD treatment led to a significant decrease in tumor borders McKallip et al., 2006. 

An additional study also showed a dose dependent increase in cellular death with 8 μg/ml CBD and 15 μg/ml CBD-DMH, respectively, after a 24 hour treatment. This would ultimately indicate that optimal doses of CBD oil regularly could provide marked decreases in cellular mutation and increases in cellular death (Apoptosis) Gallily et al., 2009.

Together, the results from the listed studies reveal that cannabidiol (CBD), acting through CB1 & CB2 receptors (directly and Indirectly), may be a novel and highly selective treatment for leukemia and other forms of cancers not only associated with the blood. Although many of these preliminary findings express safety and efficacy of CBD oil to treat certain cancers, concrete evidence through randomized controls trials will need to take place before we see integration of the treatment options with cannabis in western medical practices.

SKIN CANCER x MELANOMA x Akt 

It has become evident that Melanoma contributes to the greatest number of skin cancer-related deaths in the world. Although intensive research has been geared towards this area of cancer for decades, prevention and early detection are the only effective measures against melanoma, so new strategies are imperative for the management of cancers effecting the largest organ in the body, the skin! A recent review evaluated the efficacy of cannabinoid receptors, a new potential mechanism with antitumoral compounds. Human melanomas and melanoma cell lines express CB1and CB2 cannabinoid receptors which have indirect actions with Cannabidiol (CBD), therefore opening a whole new realm on cancer studies in regards to natural cannabis applications.

The mechanism by which cannabinoids inhibit melanoma cell proliferation was investigated in a recent study by Blazquez et al., 2006. The investigators found that through indirect activation of cannabinoid receptors melanoma cell proliferation decreased in part via inhibition of Akt, a pro-survival cellular pathway that is deregulated in many types of tumors, including melanoma. Although the use of cannabinoids in standard healthcare plans is limited, the current study displays efficacy in the management of malignant melanoma. In addition, these findings were associated with an improvement of  tumor-progression parameters, as well as with an inhibition of tumor-cell spreading, which is considered a clinical hallmark of advanced melanoma. Cannabinoid action seems to be selective for tumor vs. nontumor cells.

BREAST CANCER x Id-1 GENE EXPRESSION

Although most cancers can be characterized by cellular mutation, inflammation and neoplasia (Tumor growth) each cancer type posses a unique characteristic, which makes progression of the disease unpredictable and unique to each diagnosis and breast cancer is no exception to these characteristics.

Metastasis typically characterizes the final stages of breast cancer, meaning that the cancer has actually spread through the lymphatic system to other regions of the body and seems to be the least understood component of any cancer. The Id-1 gene has recently been shown to be a key regulator of the metastatic potential of the breast. It has recently been explained that Id-1 was down regulated with administration of cannabidiol (CBD), in aggressive human breast cancer cells. The CBD concentrations effective at inhibiting Id-1 expression correlated with those used to inhibit the proliferative and invasive activity of breast cancer cells McAllister et al., 2007

An additional study on human breast carcinoma indicated that the use of cannabis extracts enriched in either cannabidiol (CBD) or THC showed success in a panel of tumor cell lines that clearly demonstrated, of the five natural compounds tested, cannabidiol is the most potent inhibitor of cancer cell growth and proliferation, Ligresti et al., 2006. CBD represents the first nontoxic exogenous agent that can significantly decrease Id-1 expression in metastatic breast cancer cells leading to the down-regulation of tumor aggressiveness.

Although many of these findings are still in the preliminary stages, the safety and efficacy of cannabis products is becoming a force to be reckoned with. As legislations have shifted, we hope to see a change in the efforts of Americas health care system to advocate for the efficacy of cannabis to treat up to 93 different ailments including cancer, naturally.

CANCER x THE RESEARCH

Data has demonstrated the safety and efficacy of CBD in pre-clinical models of breast cancer. The results have the potential to lead to the development of revolutionized non-toxic compounds for the treatment of breast cancer metastasis, and the information gained through recent experiments broaden our knowledge of cannabinoid biology as it pertains to cancer progression Shrivastava et al., 2011.

It has been documented that endo-cannabinoid agents affect multiple signaling pathways and biological processes involved in cancer development. Emerging evidence suggests that agonists of cannabinoid receptors, which share the useful property to differentiate between tumor cells and their unchanged counterparts, could represent a tumor-selective ability to treat cancer in addition to their already exploited use to treat nausea, pain, anorexia and weight loss in cancer patients.

Although further research is needed to confirm recent findings, pre-clinical trials have demonstrated numerous times that cannabis pathways indeed play a role in multiple mechanism associated with cancer and the progression of the disease. Federal legislations have recently enabled the medical industry to take steps towards providing concrete research that will allow people to utilize safe and natural hemp remedies to improve disease and health care outcomes.

APPLICATIONS x CBD

New to CBD? check out the related link to the new user guide.

Cannabinoid options of application:

Transdermal (Skin)-Topical Salve: This application is typically used for acute and direct application. Such as an ankle sprain, arthritis, tendonitis, plantar fasciitis, carpal tunnel, tennis elbow, fibromyalgia and migraines. Full-spectrum salves provide a whole panel of cannabinoids for increased potency.

Edible Application

Tinctures: Tincture oils are utilized in full-spectrum form (whole plant derived) and Isolated forms (Pure CBD) that are applied directly under the tongue or mixed in water. This form is typically used for direct application to the central nervous system and the entire body for ailments like anxiety, stress, epilepsy, insomnia, depression, PTSD, autoimmune responses, ADHD, cancer, systemic inflammatory disease such as, cardiovascular disease, diabetes and metabolic syndrome. All applications are available as CBD isolate, broad spectrum and full spectrum.

Soft Gels: Full-spectrum soft gels essentially have the same application as tincture oils. The difference is that each soft gel is measured to a specific milligram to provide a consumer with a perfectly measured dose of CBD. This would be used for any ailments one might use CBD for, including all the ones listed above.

 Superfood powder: Super food green powder has a broad range of greens, phytonutrients, vitamins and of course CBD. This application is great to give some a nice, clean energy boost before a workout or just to get your day started naturally with improved focus.

x REFERENCES x

  1.  Jemal A, Siegel R, Ward E. Cancer statistics, 2009. CA a cancer J …2009;
  2.  Shrivastava A, Kuzontkoski PM, Groopman JE, Prasad A. Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy. Mol Cancer Ther2011;
  3.  McAllister SD, Murase R, Christian RT, et al. Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis. Breast Cancer Res Treat2011;
  4. McAllister SD, Christian RT, Horowitz MP, Garcia A, Desprez P-Y. Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells [Internet]. Mol Cancer Ther 2007;6(11):2921 LP-2927. Available from: http://mct.aacrjournals.org/content/6/11/2921.abstract
  5. Ligresti A, Moriello AS, Starowicz K, et al. Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma [Internet]. J Pharmacol Exp Ther 2006;318(3):1375 LP-1387. Available from: http://jpet.aspetjournals.org/content/318/3/1375.abstract
  6. Blázquez C, Carracedo A, Barrado L, et al. Cannabinoid receptors as novel targets for the treatment of melanoma [Internet]. FASEB J 2006;20(14):2633–Available from: https://doi.org/10.1096/fj.06-6638fje
  7. 1. McKallip RJ, Jia W, Schlomer J, Warren JW, Nagarkatti PS, Nagarkatti M. Cannabidiol-Induced Apoptosis in Human Leukemia Cells: A Novel Role of Cannabidiol in the Regulation of p22 and Nox4 Expression. Mol Pharmacol 2006;70(3):897 LP-908.
  8.  1. Gallily R, Even-Chen T, Katzavian G, Lehmann D, Dagan A, Mechoulam R. γ-Irradiation Enhances Apoptosis Induced by Cannabidiol, a Non-psychotropic Cannabinoid, in Cultured HL-60 Myeloblastic Leukemia Cells [Internet]. Leuk Lymphoma 2003;44(10):1767–73. 
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CANCER x STATS

Cancer has become a major public health concern in the United States and around the globe. It is estimated that one in four deaths in the US are due to cancer. Statistics from 2005 estimated that 1.4 million people were diagnosed with cancer that year and the estimated amount of deaths was just over half a million and the growth rate was projected to increase by 0.3% per year. In general, cancer can be characterized as neoplastic and is due to numerous cellular changes. Although all cancers are different, the common features underlying neoplasia (Tumor growth) is alterations in the cellular membrane. It has become apparent that these changes are caused by environmental factors like poor air quality, smoking tobacco, consuming excessive amounts of alcohol, poor work environments, poor diet and radiation exposure, Jemal et al., 2009.

CANCER x CBD

Cannabidiol (CBD) has been recognized as a major non-psychoactive constituent of cannabis that can be ingested or applied topically. Research has shown that cannabis possesses anti-neoplastic properties, meaning that it can inhibit or halt the development of cancerous tumors by initiating cell death, limiting inflammation, cell proliferation, and cell survival. In particular, emerging evidence suggests that cannabinoid receptors expressed by tumor cells may offer a healthier strategy to treat certain cancers, which may also depend on how aggressive it might be McAllister et al., 2011.

SKIN CANCER x MELANOMA x Akt 

It has been explained that Melanoma contributes to the greatest number of skin cancer-related deaths in the world. Although intensive research has been geared towards this area of cancer for decades, prevention and early detection are the only effective measures against melanoma, so new strategies are imperative for the management of cancers effecting the largest organ in the body, the skin! A recent review evaluated the efficacy of cannabinoid receptors, a new potential mechanism with antitumoral compounds. Human melanomas and melanoma cell lines express CB1and CB2 cannabinoid receptors, therefore opening a whole new realm on cancer studies in regards to natural cannabis applications.

The mechanism by which cannabinoids inhibit melanoma cell proliferation was investigated in a recent study by Blazquez et al., 2006. The investigators found that through activation of cannabinoid receptors melanoma cell proliferation decreased in part via inhibition of Akt, a pro-survival cellular pathway that is deregulated in many types of tumors, including melanoma. Although the use of cannabinoids in standard healthcare plans is limited, the current study displays efficacy in the management of malignant melanoma. In addition, these findings were associated with an improvement of  tumor-progression parameters, as well as with an inhibition of tumor-cell spreading, which is considered a clinical hallmark of advanced melanoma. Cannabinoid action seems to be selective for tumor vs. nontumor cells.

BREAST CANCER x Id-1 GENE EXPRESSION

Although most cancers can be characterized by cellular mutation, inflammation and neoplasia (Tumor growth) each cancer type posses a unique characteristic, which makes progression of the disease unpredictable and unique to each diagnosis and breast cancer is no exception to these characteristics.

Metastasis typically characterizes the final stages of breast cancer, meaning that the cancer has actually spread through the lymphatic system to other regions of the body and seems to be the least understood component of any cancer. The Id-1 gene has recently been shown to be a key regulator of the metastatic potential of the breast. It has recently been explained that Id-1 was down regulated with administration of cannabidiol (CBD), in aggressive human breast cancer cells. The CBD concentrations effective at inhibiting Id-1 expression correlated with those used to inhibit the proliferative and invasive activity of breast cancer cells McAllister et al., 2007

An additional study on human breast carcinoma indicated that the use of cannabis extracts enriched in either cannabidiol (CBD) or THC showed success in a panel of tumor cell lines that clearly demonstrated, of the five natural compounds tested, cannabidiol is the most potent inhibitor of cancer cell growth and proliferation, Ligresti et al., 2006. CBD represents the first nontoxic exogenous agent that can significantly decrease Id-1 expression in metastatic breast cancer cells leading to the down-regulation of tumor aggressiveness.

Although many of these findings are still in the preliminary stages, the safety and efficacy of cannabis products is becoming a force to be reckoned with. As legislations have shifted, we hope to see a change in the efforts of Americas health care system to advocate for the efficacy of cannabis to treat up to 93 different ailments including cancer, naturally.

CANCER x THE RESEARCH

Data has demonstrated the safety and efficacy of CBD in pre-clinical models of breast cancer. The results have the potential to lead to the development of revolutionized non-toxic compounds for the treatment of breast cancer metastasis, and the information gained through recent experiments broaden our knowledge of cannabinoid biology as it pertains to cancer progression Shrivastava et al., 2011.

It has been documented that endo-cannabinoid agents affect multiple signaling pathways and biological processes involved in cancer development. Emerging evidence suggests that agonists of cannabinoid receptors, which share the useful property to differentiate between tumor cells and their unchanged counterparts, could represent a tumor-selective ability to treat cancer in addition to their already exploited use to treat nausea, pain, anorexia and weight loss in cancer patients.

Although further research is needed to confirm recent findings, pre-clinical trials have demonstrated numerous times that cannabis pathways indeed play a role in multiple mechanism associated with cancer and the progression of the disease. Federal legislations have recently enabled the medical industry to take steps towards providing concrete research that will allow people to utilize safe and natural hemp remedies to improve disease and health care outcomes.

APPLICATIONS x CBD

New to CBD? check out the related link to the new user guide.

Cannabinoid options of application:

Transdermal (Skin)-Topical Salve: This application is typically used for acute and direct application. Such as an ankle sprain, arthritis, tendonitis, plantar fasciitis, carpal tunnel, tennis elbow, fibromyalgia and migraines. Full-spectrum salves provide a whole panel of cannabinoids for increased potency.

Edible Application

Tinctures: Tincture oils are utilized in full-spectrum form (whole plant derived) and Isolated forms (Pure CBD) that are applied directly under the tongue or mixed in water. This form is typically used for direct application to the central nervous system and the entire body for ailments like anxiety, stress, epilepsy, insomnia, depression, PTSD, autoimmune responses, ADHD, cancer, systemic inflammatory disease such as, cardiovascular disease, diabetes and metabolic syndrome. All applications are available as CBD isolate, broad spectrum and full spectrum.

Soft Gels: Full-spectrum soft gels essentially have the same application as tincture oils. The difference is that each soft gel is measured to a specific milligram to provide a consumer with a perfectly measured dose of CBD. This would be used for any ailments one might use CBD for, including all the ones listed above.

 Superfood powder: Super food green powder has a broad range of greens, phytonutrients, vitamins and of course CBD. This application is great to give some a nice, clean energy boost before a workout or just to get your day started naturally with improved focus.

x REFERENCES x

  1.  Jemal A, Siegel R, Ward E. Cancer statistics, 2009. CA a cancer J …2009;
  2.  Shrivastava A, Kuzontkoski PM, Groopman JE, Prasad A. Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy. Mol Cancer Ther2011;
  3.  McAllister SD, Murase R, Christian RT, et al. Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis. Breast Cancer Res Treat2011;
  4. McAllister SD, Christian RT, Horowitz MP, Garcia A, Desprez P-Y. Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells [Internet]. Mol Cancer Ther 2007;6(11):2921 LP-2927. Available from: http://mct.aacrjournals.org/content/6/11/2921.abstract
  5. Ligresti A, Moriello AS, Starowicz K, et al. Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma [Internet]. J Pharmacol Exp Ther 2006;318(3):1375 LP-1387. Available from: http://jpet.aspetjournals.org/content/318/3/1375.abstract
  6. Blázquez C, Carracedo A, Barrado L, et al. Cannabinoid receptors as novel targets for the treatment of melanoma [Internet]. FASEB J 2006;20(14):2633–Available from: https://doi.org/10.1096/fj.06-6638fje

 

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CANCER x STATS

Cancer has become a major public health concern in the United States and around the globe. It is estimated that one in four deaths in the US are due to cancer. Statistics from 2005 estimated that 1.4 million people were diagnosed with cancer that year and the estimated amount of deaths was just over half a million and the growth rate was projected to increase by 0.3% per year. In general, cancer can be characterized as neoplastic and is due to numerous cellular changes. Although all cancers are different, the common features underlying neoplasia (Tumor growth) is alterations in the cellular membrane. It has become apparent that these changes are caused by environmental factors like poor air quality, smoking tobacco, consuming excessive amounts of alcohol, poor work environments, poor diet and radiation exposure, Jemal et al., 2009.

CANCER x CBD

Cannabidiol (CBD) has been recognized as a major non-psychoactive constituent of cannabis that can be ingested or applied topically. Research has shown that cannabis possesses anti-neoplastic properties, meaning that it can inhibit or halt the development of cancerous tumors by initiating cell death, limiting inflammation, cell proliferation, and cell survival. In particular, emerging evidence suggests that cannabinoid receptors expressed by tumor cells may offer a healthier strategy to treat certain cancers, which may also depend on how aggressive it might be McAllister et al., 2011.

BREAST CANCER x Id-1 GENE EXPRESSION

Although most cancers can be characterized by cellular mutation, inflammation and neoplasia (Tumor growth) each cancer type posses a unique characteristic, which makes progression of the disease unpredictable and unique to each diagnosis and breast cancer is no exception to these characteristics.

Metastasis typically characterizes the final stages of breast cancer, meaning that the cancer has actually spread through the lymphatic system to other regions of the body and seems to be the least understood component of any cancer. The Id-1 gene has recently been shown to be a key regulator of the metastatic potential of the breast. It has recently been explained that Id-1 was down regulated with administration of cannabidiol (CBD), in aggressive human breast cancer cells. The CBD concentrations effective at inhibiting Id-1 expression correlated with those used to inhibit the proliferative and invasive activity of breast cancer cells McAllister et al., 2007

An additional study on human breast carcinoma indicated that the use of cannabis extracts enriched in either cannabidiol (CBD) or THC showed success in a panel of tumor cell lines that clearly demonstrated, of the five natural compounds tested, cannabidiol is the most potent inhibitor of cancer cell growth and proliferation, Ligresti et al., 2006. CBD represents the first nontoxic exogenous agent that can significantly decrease Id-1 expression in metastatic breast cancer cells leading to the down-regulation of tumor aggressiveness.

Although many of these findings are still in the preliminary stages, the safety and efficacy of cannabis products is becoming a force to be reckoned with. As legislations have shifted, we hope to see a change in the efforts of Americas health care system to advocate for the efficacy of cannabis to treat up to 93 different ailments including cancer, naturally.

CANCER x THE RESEARCH

Data has demonstrated the safety and efficacy of CBD in pre-clinical models of breast cancer. The results have the potential to lead to the development of revolutionized non-toxic compounds for the treatment of breast cancer metastasis, and the information gained through recent experiments broaden our knowledge of cannabinoid biology as it pertains to cancer progression Shrivastava et al., 2011.

It has been documented that endo-cannabinoid agents affect multiple signaling pathways and biological processes involved in cancer development. Emerging evidence suggests that agonists of cannabinoid receptors, which share the useful property to differentiate between tumor cells and their unchanged counterparts, could represent a tumor-selective ability to treat cancer in addition to their already exploited use to treat nausea, pain, anorexia and weight loss in cancer patients.

Although further research is needed to confirm recent findings, pre-clinical trials have demonstrated numerous times that cannabis pathways indeed play a role in multiple mechanism associated with cancer and the progression of the disease. Federal legislations have recently enabled the medical industry to take steps towards providing concrete research that will allow people to utilize safe and natural hemp remedies to improve disease and health care outcomes.

New to CBD? check out the related link to the new user guide.

Cannabinoid options of application:

Transdermal-Topical Salve

Edible-Tinctures, Superfood powder, Soft Gels, Waters.

x REFERENCES x

  1.  Jemal A, Siegel R, Ward E. Cancer statistics, 2009. CA a cancer J …2009;
  2.  Shrivastava A, Kuzontkoski PM, Groopman JE, Prasad A. Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy. Mol Cancer Ther2011;
  3.  McAllister SD, Murase R, Christian RT, et al. Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis. Breast Cancer Res Treat2011;
  4. McAllister SD, Christian RT, Horowitz MP, Garcia A, Desprez P-Y. Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells [Internet]. Mol Cancer Ther 2007;6(11):2921 LP-2927. Available from: http://mct.aacrjournals.org/content/6/11/2921.abstract
  5. Ligresti A, Moriello AS, Starowicz K, et al. Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma [Internet]. J Pharmacol Exp Ther 2006;318(3):1375 LP-1387. Available from: http://jpet.aspetjournals.org/content/318/3/1375.abstract

 

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RAMS x PATRIOTS

Whether you were on the winning team or the losing team this past weekend chances are you had a bit too much to drink, ten slices of pizza and the load of chips and salsa. We all know that times of celebration often lead you to putting things in your body that are not necessarily good for you when consumed in excess. Research and has shown that consuming excess carbohydrates and alcohol can not only causes gastrointestinal inflammation, but also inflammation of the kidneys, liver and brain, Wang et al., 2010. Although a hangover and a nasty stomachache subside fairly quickly, the repercussions of the party time celebrations often go unnoticed. Science has been uncovering new ways people can monitor dietary intake along with discoveries that can help keep our body strong with natural remedies like cannabis that act with preventative application. 

CANNABIS x CBD

Emerging studies and animal models have exposed the safety and efficacy of cannabidiol (CBD) and research has shown statistically significant impacts on reducing gut inflammation, pain due to gastrointestinal distress and overall improvements in intestinal digestion. More recent reviews have also revealed that the endocannabinoid system is involved in almost all major immune events and therefore, it may be beneficial in all inflammatory disorders. A review on colitis shows that in response to cannabinoid up-regulation histologic and microscopic gut inflammation was reduced Naftali et al., 2014.

An additional study explains that the endocannabinoid system is involved in the regulation of numerous gastrointestinal functions including motility, sensation and secretion. Under pathophysiological conditions the endocannabinoid system provides protection to the gastrointestinal (GI) tract (e.g. from inflammation and abnormally high gastric and enteric secretions). Protective activities are largely in agreement with preliminary reports on the use of cannabis extracts by subjects suffering from various GI disorders. Thus, the endocannabinoid system may serve as a potentially promising therapeutic application against different GI disorders, including inflammatory bowel diseases (e.g. Crohn's disease), functional bowel diseases (e.g. irritable bowel syndrome) and secretion and motility related disorders.

FEEDING THE CANNABINOID SYSTEM

The endocannabinoid (eCB) system includes multiple receptor sites that can be interacted with directly or indirectly. CB1 and CB2, endocannabinoid ligands anandamide (AEA) and 2-arachidonoylglycerol (2-AG), and their metabolic enzymes all make up the intricate system that parallels our immune and central nervous system.

Emerging literature has documented cannabinoid deficiency as process in migraines, fibromyalgia, irritable bowel syndrome, psychological disorders, and other related conditions characterized by inflammation and cannabinoid deficiency. A review of clinical interventions indicate that several classes of pharmaceuticals can up-regulate the endocannabinoid system, including analgesics (acetaminophen, non-steroidal anti-inflammatory drugs, opioids, glucocorticoids), antidepressants, antipsychotics, anxiolytics, and anticonvulsants. Clinical interventions characterized as "complementary and alternative medicine" also upregulate the endocannabinoid system: massage and manipulation, acupuncture, dietary supplements, herbal medicines and lifestyle modification such as, diet, weight control, and exercise also modulate the endocannabinoid system, Storr et al., 2008.

THE HEALTHY OPTION x CBD

Although science has shown that pharmaceutical drugs can interact with the endocannabinoid system to up regulate the production of cannabinoids, this does not serve as a natural means to treat certain ailments associated with inflammation and the endocannabinoid system. There is a reason we feed the endocannabinoid system with cannabinoids, our body is naturally made to do so and thrives on the actions that it provides. If we had a "Tylenol system" or an "Ibuprofen system" I would not be sitting behind my desk pushing information on cannabis and the constitutes that have been medically proven to treat illness and injury naturally. I believe that if we are sacrificing our body for a good time, the least we can do is treat and heal with the cleanest and most naturally occurring remedies possible.

Cannabinoid options of application:

Transdermal-Topical Salve

Edible-Tinctures, Superfood powder, Soft Gels, Waters.

x References x

1. Wang HJ, Zakhari S, Jung MK. Alcohol, inflammation, and gut-liver-brain interactions in tissue damage and disease development. World J Gastroenterol 2010;

2. Naftali T, Mechulam R, Lev LB, Konikoff FM. Cannabis for inflammatory bowel disease. Dig Dis 2014;

3. Storr MA, Yüce B, Andrews CN, Sharkey KA. The role of the endocannabinoid   system in the pathophysiology and treatment of irritable bowel syndrome. Neurogastroenterol Motil 2008;

4. Massa F, Storr M, Lutz B. The endocannabinoid system in the physiology and pathophysiology of the gastrointestinal tract. J Mol Med 2005;

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CANCER x STATS

Cancer has become a major public health concern in the United States and around the globe. It is estimated that one in four deaths in the US are due to cancer. Statistics from 2005 estimated that 1.4 million people were diagnosed with cancer that year and the estimated amount of deaths was just over half a million and the growth rate was projected to increase by 0.3% per year. In general, cancer can be characterized as neoplastic and is due to numerous cellular changes. Although all cancers are different, the common features underlying neoplasia (Tumor growth) is alterations in the cellular membrane. It has become apparent that these changes are caused by environmental factors like poor air quality, smoking tobacco, consuming excessive amounts of alcohol, poor work environments, poor diet and radiation exposure, Jemal et al., 2009.

CANCER x CBD

Cannabidiol (CBD) has been recognized as a major non-psychoactive constituent of cannabis and research has shown that cannabis possesses anti-neoplastic properties, meaning that it can inhibit or halt the development of cancerous tumors by initiating cell death, limiting inflammation, cell proliferation, and cell survival. In particular, emerging evidence suggests that cannabinoid receptors expressed by tumor cells may offer a healthier strategy to treat certain cancers, which may also depend on how aggressive it might be, McAllister et al., 2011.

CANCER x THE RESEARCH

Data has demonstrated the safety and efficacy of CBD in pre-clinical models of breast cancer. The results have the potential to lead to the development of revolutionized non-toxic compounds for the treatment of breast cancer metastasis, and the information gained through recent experiments broaden our knowledge of cannabinoid biology as it pertains to cancer progression, Shrivastava et al., 2011.

It has been documented that endo-cannabinoid agents affect multiple signaling pathways and biological processes involved in cancer development. Emerging evidence suggests that agonists of cannabinoid receptors, which share the useful property to differentiate between tumor cells and their unchanged counterparts, could represent a tumor-selective ability to treat cancer in addition to their already exploited use to treat nausea, pain, anorexia and weight loss in cancer patients.

Although further research is needed to confirm recent findings, pre-clinical trials have demonstrated numerous times that cannabis pathways indeed play a role in multiple mechanism associated with cancer and the progression of the disease. Federal legislations have recently enabled the medical industry to take steps towards providing concrete research that will allow people to utilize safe and natural hemp remedies to improve disease and health care outcomes.

x REFERENCES x

  1. Jemal A, Siegel R, Ward E. Cancer statistics, 2009. CA a cancer J …2009;
  2. Shrivastava A, Kuzontkoski PM, Groopman JE, Prasad A. Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy. Mol Cancer Ther2011;
  3. McAllister SD, Murase R, Christian RT, et al. Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis. Breast Cancer Res Treat2011;

 

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DO NOT BE FOOLED

More often than not you hear people making claims about…this does this and that does that! But how often are claims actually supported by science, versus claims that are only supported by word of mouth or an individual’s experience? It has become far too normal for people to make recommendations or claims that are fallacious and are in no way supported by science... I like to call it "bro science". This really becomes an issue when the claims people are making can be potentially damaging to the person you provide the recommendations.

NLEA x FDA x CBD

Health claims on food labels are currently regulated under the 1990 nutrition labeling and education act (NLEA) and more specifically, regulation guidelines had been issued in 1994 by the US food and drug administration (FDA). The intent of these laws are manifested by the implementation of them, which are supposed to limit what claims are to be made unless otherwise backed by scientific research, Roe et al.,1999. However, today there is much debate as to whether or not these guidelines are true or followed appropriately under the regulation of the FDA. This makes you wonder what type of claims are currently being made with regards to products that are NOT regulated by the FDA, like Cannabidiol (CBD) and fitness supplements such as creatine and protein powders.

WHAT DOES THIS MEAN?

Cannabidiol (CBD) has recently exploded onto the market place targeting a wide range of demographics, and with that a flood of new content has emerged on to everyones favorite super duper scientific based platform, otherwise know as GOOGLE. Although there is tons of new research and literature that supports the use of CBD for treating pain and inflammation (if you know where to look), often times people make recommendations to replace clinically prescribed medication with CBD or to couple them together. The problem here is that there is almost no evidence that conclusively states the interactions or the adverse events that may occur while taking other medications with CBD. It is ALWAYS best to consult your physician if your are not certain about the interactions you may experience. Often times people do not take in to consideration that every single person is different and with that, so is their responses to cannabis and almost anything else.

I recently stumbled across a prime example of what NOT to do or follow if given this sort of recommendation. A person claimed that they were having an orthopedic issue with their heel and that they have been taking CBD with no therapeutic response. An individual encouraged them to INCREASE the dose! Do you see the problem here? For one, research states that there is a dose response relationship to cannabis, Hammell et al., 2016, Philpott et al., 2017, meaning that relatively little amounts will produce no therapeutic response, an optimal response would be somewhere in the middle, and a poor response could be attributed to taking too much. With that said, one should never take a personal recommendation and provide someone with that exact dosage claim. This was just a small yet significant example of the inability to acquire knowledge that is backed by science. In this case individuals should seek professional help from their physician to address the underlying condition, rather than just trying to mask a chronic issue that could potentially become lifelong if not dealt with appropriately.

When CBD is used the way it was intended it may do wonders for some people and almost nothing for others. It should be strongly encouraged that if the underlying condition is serious enough to seek medical attention, consult your physician about coupling CBD with your current treatment plan. This will help maximize the benefits of both CBD and professional treatment options. Finding the optimal dose may take some time and consistency... Be mindful of what your body is telling you, not what other bodies are telling you.

x REFRENCES x

Roe B, Levy AS, Derby BM. The impact of health claims on consumer search and product evaluation outcomes: Results from FDA experimental data. J Public Policy Mark1999;

Hammell DC, Zhang LP, Ma F, et al. Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis. Eur J Pain (United Kingdom)2016;

Philpott HT, O’Brien M, McDougall JJ. Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. Pain2017;

 

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 HOMELESSNESS x HAWAII

Through the doggy door is a documentary about the life of Sheldon Paishon, his struggles with homelessness on the west side of Oahu and his endless desire to chase his dream of becoming a professional surfer. Although the film has only recently begun to take shape, the beginning of this story came to life when professional surfer Mason Ho took Sheldon under his wing roughly a decade ago. The long rough road for Sheldon has slowly started to take shape with many helping hands, which has set the stage in 2019 for the journey to glory and professional surfing to become a reality.

WHO IS SHELDON PAISHON?

Sheldon “Shel-Doggy Door” Paishon, was born and raised on the rugged shores of Oahu’s Westside, home to the famous Makaha beach. The island paradise of the west side is home to some of the most beautiful beaches in the world, yet the community has been largely impacted by poverty, drug abuse and the harsh realities that come along with it. Often times people think Hawaii and all they dream of is an island paradise... For Sheldon, growing up was indeed a paradise, but more like a paradise lost. At a very young age Sheldon’s parents fell on difficult times and found themselves living in a tent on the beach for many years. Despite the challenges Sheldon faced through his adolescence, Sheldon just kept surfing...all day every day!! Through the helping hands of others and a deep passion for the sport, Sheldon has risen to the edge of sustaining a career as a professional surfer. He recently claimed his first Pro Tour victory in Tahiti, March of 2018 and this is just the start!!

Mason and Sheldon have known each other since they were kids, but more recently Mason has stepped into the older brother role and has begun mentoring Sheldon and showing him the way into the professional surfing world, even when it means funding Sheldon's ventures out of his own pocket!! Mason has taken Sheldon around the globe and even managed to support a big decision made by legendary surf brand Rip Curl to offer Sheldon a professional contract, which is also Mason's title sponsor. This will allow Sheldon to take on the 2019 season in attempt to chase his dream of qualifying for the championship tour.

x THE FILM x

The film focuses on Sheldon's struggles as a kid and follows his progress from a very young reckless teen to a more matured individual with drive and focus.  The story will dive into the depths of Sheldon's life and challenges he faced as a homeless teen, along with the community members that helped him along his reckless journey. The story reveals the socio-economic realities and hardships for locals on the west Oahu shores and will bring to life the inspirational journey Sheldon has endured.

With the help from Alani media and Rory Pringle productions, Mason and Sheldon have set out to not only create an amazing surf film covering different parts of the globe absolutely ripping... The film will create awareness for the state of Hawaii and the challenges many locals face every single day. I believe kids will look to Sheldon as a person that proved not matter what odds you are up against, there is always hope!! 

To be continued...

 

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SLEEP DISORDERS x THE STATS

It has been estimated that about 50-70 million of Americans today suffer from some form of sleep related disorder and roughly 11% of individuals who have reported sleep issues suffer from sleep disturbances almost daily. Investigators have explained that both adolescents and adults that suffer from chronic insomnia may develop depression and anxiety related conditions later in life. Studies have also explained that people who suffer from sleep disorders are likely to develop issues with substance abuse, alcohol dependency and decreases in work performance.

In recent years research has focused the attention towards holistic approaches to find ways in which people can control their poor sleeping habits, without pharmaceutical intervention. Research and literature has recently been highlighting the impacts of melatonin and cannabidiol (CBD) as a natural sleep remedy and the results have been showing much promise in both animal and human models as a means to regulate poor sleep patterns.

MELATONIN:

Research from the early 1970’s identified that melatonin is produced by the pineal gland within the brain, which plays an important role in circadian variation and sleep regulation. Normal increases in melatonin concentrations occur at night to induce sleep and little to no concentrations during the day, while cortisol levels rise to induce arousal. However, growing evidence has shown that as we age, decreases in melatonin concentrations contribute to poor sleeping patterns, which can also be identified in adolescents who experience poor circadian variation due to factors such as stress and anxiety.

A clinical review investigated both the safety and efficacy of melatonin for sleep disorders. Although the report was not conclusive as to whether or not sleep related disorders can be treated with melatonin, the authors did explain that there is some evidence to suggest that melatonin is effective in treating delayed sleep latency with short-term use. The study also explained that there is evidence to suggest that melatonin is safe with short term use, less than 3 months and can be used in moderation to naturally regulate circadian rhythm (Buscemi et al., 2005). If you are unsure about administering melatonin please consult your physician for more information on whether or not it is right for you.

CANNABIDIOL (CBD):

Cannabidiol (CBD), one of the main constituents of cannabis has been known to possess hypnotic effects and has been identified as a natural sleep remedy that can improve overall quality of sleep by naturally regulating circadian rhythm. This response occurs by interaction with cannabinoid receptors within the central nervous system, immune system and the periphery. However, further research is needed to identify the underlying mechanisms associated with the effects of CBD on sleep regulation.

CLINICAL REVIEW

 A recent clinical review stated that individuals who ingested 160 mg/day showed that both sleep duration and quality were significantly improved without any adverse effects in relationship to the placebo and nitrazepam (5 mg). An additional study recently published found that CBD provided notable therapeutic applications on circadian rhythm and was consistent with clinical trials that state the therapeutic effects of CBD, but not THC to treat insomnia by triggering regions of the brain responsible for sleep regulation (Lafaye et al., 2018).

Although insomnia is just one of many sleep disorders, CBD has shown to have significant impacts on sleep duration and time, which has been recognized in animal and human models (Lafaye et al., 2018, Murillo-Rodríguez et al., 2006, Chagas et al., 2013). This ultimately allows the body’s natural ability to control sleep with the administration of CBD and can have significant impacts across a variety of sleep disorders. However, further research is still needed to prove these results and how CBD acts to control variations in naturally occurring cortisol and melatonin concentrations.

We identify that CBD and melatonin can have different individual subject responses in sleep patterns and sleep regulation. However, the literature has expressed the safety and the efficacy of both CBD and melatonin in subjects experiencing sleep deficiencies. We hope further research will be able to identify optimal dose responses of both products to maximize the therapeutic benefits of these natural remedies.

References:

  1. Buscemi N, Vandermeer B, Hooton N, et al. Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: Meta-analysis. Br Med J2006;.
  2. Zhornitsky S, Potvin S. Cannabidiol in humans-The quest for therapeutic targets. Pharmaceuticals2012;.
  3. Lafaye, G., Desterke, C., Marulaz, L., and Benyamina, A. (2018) Cannabidiol affects circadian clock core complex and its regulation in microglia cells. Addiction Biology, https://doi.org/10.1111/adb.12660.
  4. Murillo-Rodríguez E, Millán-Aldaco D, Palomero-Rivero M, Mechoulam R, Drucker-Colín R. Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats. FEBS Lett2006;.
  5. Chagas MHN, Crippa JAS, Zuardi AW, et al. Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats. J Psychopharmacol2013;.

 

 

 

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Eli Olson…there is nothing bad you can say about the guy! Born and raised on the North Shore of Oahu and like many of his close friends (Koa Rothman, Nathan Florence, John Florence 2 x World Champion and Kiron Jabour) he has finally begun to stich his name into the surfing world. However, Eli did not always have a recognizable name in surfing.  In fact, Eli spent many years struggling for sponsorship and grinding him self to the point in which many athletes would throw in the towel, but that's not Eli's style!!  Aside from surfing he has also set out to create an additional path that parallels his surfing ability, Jiu-Jitsu!!

Eli has spent the last decade morphing himself into a brown belt beast, which seems to translate seamlessly into his surfing, explosive and hard charging. This winter Eli has already thrown himself over the ledge of a massive outer reef bomb at Log Cabins during a solo session, along with trips to Mavericks and Jaws chasing down the biggest surf on the planet!! The dude is no joke!

I had the pleasure of growing up with Eli and spent many years with him terrorizing the North Shore and watched him transform from a little grom, to the humble beast that he is today. It has been amazing to watch this guy evolve over the years. Eli currently holds a 2017 WSL (world surf league regional championship), along with a WSL win at Ala Moana bowls and a 2017 NAGA (North America Grappling Association) championship belt in the pro division and a runner-up finish in the 2018 NAGA championship.

I recently spoke with Eli after we signed him and asked what his biggest application  of CBD will be for 2019 and beyond...

Eli Olson: Im just looking to take my game to a whole new level!! And on that note we would like to officially welcome Eli Olson to the NanoCraft CBD team. 

Eli Olson, Left x Joel Tudor, Right

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