The Journal of the Neurological Sciences provides a medium for the prompt publication of original articles in neurology and neuroscience from around the world. JNS places special emphasis on articles that provide guidance to clinicians around the world,report cutting-edge science related to neurology, educate readers about relevant and practical clinical outcomes in neurology.
Affecting 2.5 million people worldwide, multiple sclerosis (MS) is one of the main causes of acquired disability among young adults. In French West Indies (FWI), where MS has arisen from the end of the 80's, a low therapeutic response to interferons beta1 (IFN beta1) in patients of African descent, restrains the therapeutic options. Fingolimod is a Sphingosine-1-Phosphate receptor modulator whose efficacy in the treatment of MS has recently been shown in three phase III studies. Nevertheless, data are currently lacking concerning the use of Fingolimod among populations of African descent, particularly in a real-world setting.
Patients with Parkinson's disease (PD) experience various symptoms, both from the disease progression itself and the medication. Few large-scale studies have investigated the associations between zonisamide and these symptoms. This study compared zonisamide and other anti-PD drugs by analyzing their associations with the incidence of PD-relevant symptoms.
The response to stroke in Nigeria is impaired by inadequate epidemiologic information. We sought to collate available evidence and estimate the incidence of stroke and prevalence of stroke survivors in Nigeria.
We read with interest the letter of comments “Predictors of respiratory impairment in patients with myotonic dystrophy type 1” by Prof. Kawada  about our work concerning the assessment of the prevalence and predictors of respiratory impairment by a cross-sectional study on a large Italian cohort, recently published on Your Journal .
Rossi et al. conducted a cross-sectional study to evaluate predictors of respiratory impairment in 268 patients with myotonic dystrophy type 1 (DM1) . Restrictive respiratory syndrome (respiratory impairment) was defined as forced vital capacity (FVC) <80%, and 139 patients (51.9%) showed having impairment. In multivariate analysis, score of muscular impairment rating scale (MIRS) and mean cytosine-thymine-guanine nucleotide (CTG)n values in leukocytes were selected as significant predictors for respiratory impairment.
Direct oral anticoagulants (DOACs) can reduce the frequency of cardioembolic stroke with non-valvular atrial fibrillation as well as or better compared to vitamin K antagonists (VKAs). However, whether taking DOACs prior to stroke can prevent acute major cerebral artery occlusion (MCAO) has not been fully elucidated.
We read with interest the response of Armocida and Martini  to our proposal for a retrospective diagnosis of the case of Anna O. , and we agree that this diagnosis is hardly compatible with tuberculosis in its current form. But it is precisely an old form of the disease, occurring on a population radically different from the current population.