Hi everyone. I don't often post to this blog any more because there's little new to say and you can get most of the information easily online. I do still answers questions regularly at stevecarper @ cs.com. Is mascarpone a low-lactose cheese? Yes. Does blood from injured cows get into milk, making it undrinkable to Orthodox Jews? No, it might have happened in some very rare cases but the milk supply is safe.
And if people send me news updates to what I've already posted about I pay attention.
Well, back almost three years ago I posted Lacto-Freedom - Sometime in the Future? That told the story of Ken Manzo, who was trying to raise money for a new probiotic to prevent the fermentation of undigested lactose in the intestines. Since that's the reason most people get gas pains from lactose, that would be very big news.
He just emailed me to let me know that he succeeded. Lacto-Freedom is available for sale. That's remarkably quick for a new product.
Here's what he says on that site:
Aids in the digestion of lactose containing foods.*
Take it for only 7 days and effects last for months.
Enjoy your favorite dairy foods without the discomfort associated with lactose sensitivity.
Patented, developed by a pharmacist
A new and unique patented probiotic that aids in the digestion of lactose containing foods, designed specifically for people with lactose sensitivity.* After taking the probiotic for only 7 days, it stays in the intestines and produces lactase and reduces or eliminates the issues associated with lactose products for months so you can enjoy dairy without the discomfort. ...
How it works: The intestinal lining is made up of billions of bacteria, both good and bad. Probiotics are supplements which contain “good” bacteria and when consumed add beneficial bacteria to the intestines. We developed a probiotic that stays in the intestines, produces lactase, and allows the body to more efficiently digest lactose for months, so you can enjoy dairy without the discomfort.
A clinical study was done by Celprogen Inc. but consisted of only 8 test subjects. I wish that number was higher. Subjects ate a normal diet but submitted to "milk challenges" - drinking an eight ounce glass of milk and reporting their discomfort level. That discomfort shrank for the eight weeks in the trial.
A bottle of 21 Lacto-Freedom capsules costs $24.99 and can be ordered using the Buy Now button on the information page. Shipping is $2.99 in the U.S. If you're not in the U.S. the software should generate a shipping rate for you. You can also find Lacto-Freedom on Amazon, but the shipping is higher there. It is only available online.
Standard disclaimer. I have not used this product or know anyone who has. Please read all the information on the site before ordering. Follow all directions when taking the product. There is a contact page if you have further questions.
If you try it, please let me know what happens, whether it works or doesn't or winds up somewhere in the middle. I have to approve comments so they may not show up instantly, but I'll get to them and post anything I receive. (Except trolls and spam, of course. You get nowhere.)
This is your Valentine's Day nightmare. You indulge yourself in a pricey bar of sumptuous dark chocolate. Dairy-free is on the label. But the palpitations you feel aren't from Cupid's arrow but from anaphylactic shock.
The U.S. Food and Drug Administration (FDA) recently ran a study on 100 dark chocolate products. Many of them contained milk, some in levels high enough to be a serious problem to many who are allergic to milk proteins.
Labeling on the chocolates was inconsistent. Some did say that they "main contain traces of milk." Others, however, said definitively that they were "dairy-free" or even "allergen-free." Many had no warning labeling of any kind.
What the FDA Study Found“First of all, milk-allergic consumers should be aware that a high proportion of the dark chocolates we tested contained milk, even when the label failed to list milk as an ingredient,” [Binaifer Bedford, M.S., an Oak Ridge Institute for Science and Education (ORISE) fellow at FDA] says. Of greatest concern are chocolate samples that have no statement regarding milk on the label or have inconsistencies in the label. Several of the chocolates labeled “dairy free” were also found to contain milk.
While dark chocolates labeled “dairy free or allergen-free” were the least likely to contain milk, two out of 17 of these products were found to contain milk.
All seven bars that declared the presence of milk on the label contained milk; however, 55 (59%) of 93 bars without any clear indication of the presence of milk also were found to contain milk.
Six out of the eleven chocolate products labeled “traces of milk” contained milk at detectable levels high enough to potentially cause severe reactions in some individuals.
What can you as a consumer do when a manufacturer lies to or misleads you? The FDA has a few recommendations, which are far less than perfect yet may make a difference in the long run.
Research, read, complain. Three little words not quite as romantic as I Love You, but they may change your life just as dramatically.
UPDATE: May 29, 2015
Good news for Jeff Bezos. Old media apparently is still powerful, driving news on the Internet. This three-month-old announcement has suddenly spawned articles on numerous sites. The only possible reason I can find is that Roberto A. Ferdman of the Washington Post's Wonkblog just put out an article about it. Always glad to see important findings reach a larger public, but this is a tiny bit scary. A consumer-friendly handout from the FDA takes three months to go the ten miles from the FDA compound to the Washington Post building? Really? Are there other things in that pipeline that Ferdman should be getting to? I'm an old-line print advocate and newspaper reader but this is an example of the superiority of a Google News feed.
Atlanta-based Coca-Cola Co. has the largest-selling soft drink brand around the globe and now it’s “got milk.”
Sandy Douglas, president of Coca-Cola North America, recently said at a Morgan Stanley Global Consumer Conference that Coca-Cola will roll out a no-lactose milk product that will be in stores in late December.
Douglas called Fairlife, the name of the new product, “the premiumization of milk.” According to a transcript of his appearance, the executive said the product tastes better than regular milk and is better for you due to “a proprietary milk filtering process that allows you to increase protein by 50 percent take sugar down by 30 percent and have no lactose.”
But Fairlife won’t be cheap. “[We’ll] charge twice as much for it as the milk we used to buying in a jug,” Douglas said, according to Seeking Alpha transcript of his remarks. A price was not provided.
Coca-Cola has been investing more in non-carbonated beverages such as juices and teas, given a decline in soda sales not only for the company for also for its competitors, especially in North America as health-conscious consumers seek out more nutritious alternatives.
Fairlife is a Chicago company that also makes Core Power lactose-free protein drinks and has partnered with Pinkberry on yogurt development.
They have a long section of FAQs on this new milk.
Is fairlife purely nutritious milk™ real milk?Absolutely! It’s 100% real with amazing taste and better nutrition because of our nifty filtration process. Watch our short video to see how it’s done! Where does the extra protein and calcium come from in fairlife purely nutritious milk™?It comes directly from the milk! We filter our milk into its five components (water, butterfat, protein, vitamins & minerals, lactose) and then recombine them in different proportions. So we never need to add protein or calcium powders – it’s already in the milk! Is fairlife purely nutritious milk™ natural?Our skim and 2% milks are natural, but our chocolate milk is sweetened for your pleasure. Is fairlife purely nutritious milk™ organic?Just like organic milk, we never treat our cows with rBST growth hormones. However, we offer them 24/7 shelter and protection from the elements, while organic milk cows aren’t able to have the same luxury. Visit our flagship farm to see our industry-leading sustainability and cow comfort in practice. Is fairlife purely nutritious milk™ safe for kids?Sure! After all, it’s real milk. It has as much protein as a typical greek yogurt, with 50% more calcium and half the sugar of ordinary milk. It’s a nutritious part of a daily diet for all ages. Why does fairlife purely nutritious milk™ have a longer shelf life than ordinary milk?It’s simply in the processing. Ordinary milk is pasteurized at a high temperature for 15-20 seconds. We pasteurize our milk at an even higher temperature for less time. That gives fairlife much longer shelf life unopened. After opening, its shelf life is the same as ordinary milk. Where are the fairlife farms?We source our milk from the farm families that founded fairlife. These farms are located all over the country, with our flagship farm in Fair Oaks, Indiana, open to visitors year-round. Come see us! Why is fairlife purely nutritious milk™ lactose-free and does it taste different?Some people find that lactose (the natural sugar found in milk) upsets their stomachs, so we take it out so everyone can enjoy fairlife. You won’t be able to taste the difference (unlike other lactose-free milks). Is fairlife packaging recyclable?Yes, our bottles are #7 recyclable. To find out how to recycle your plastic locally, go to earth911.com, click on ‘recycling search’, select the ‘plastic’ icon, select #7 plastic bottles and input your zip code.
The national announcement and rollout brought sudden attention to the advertising campaign they ran in test markets in the spring. Fairlife used images from a pin-up girls calendar of models apparently wearing dresses made from milk, a campaign introduced last year by AurumLight.com from photographer Jaroslav Wieczorkiewicz. Multitudes online blasted for the campaign for being sexist, which of course it was, and wondering what pin-up girls wearing milk dresses have to do with selling a new premium milk, which of course is an easily answerable question. Coke is of course not using the already expired campaign.
There are other and better places to vent outrage. What you need to know is whether the actual product is worthy or not. Molly Blake on the Today show website talked to registered dietitian Michelle Dudash:
“It has a lot of really good qualities,” said Dudash, author of “Clean Eating for Busy Families.” The beverage boasts it contains 50 percent more natural protein and 30 percent more natural calcium than regular milk, as well as 50 percent less sugar.
And it’s lactose free,” added Dudash, an obvious boon to the millions of Americans who suffer from an intolerance to lactose and can't enjoy some of the health benefits that regular milk has been shown to have.
A diet that includes 8 oz. of milk a day is associated with healthy bones and teeth among other health benefits. A study by the University of Massachusetts at Amherst found that women can lower their risk of PMS by drinking either skim or low-fat milk all month long.
But sales of milk have been flattening out since the 1970’s and half of US adults don’t drink milk. One reason is that milk is perceived to be fattening and sugar-filled.
“Milk isn’t the enemy when it comes to sugar,” said Dudash. “But for diabetics and anyone who is really watching their carbohydrate intake closely, the 6 grams of difference between regular milk and Fairlife can be significant.”
The added protein and calcium also make Fairlife attractive, as it’s essential to have a diet that includes protein from a variety of sources including lean meats, nuts, seeds and milk.
“Fairlife, therefore, can be a good item to add to your protein portfolio,” said Dudash.
Lactose free milk has been available at every major supermarket for years, if not decades. It's normally far more expensive than regular milk mostly because it is made in tiny quantities and so doesn't enjoy the economy of scale that allows regular milk to be sold so cheaply. Fairlife won't change this. It's being billed as "premium" milk, so it may be even more expensive than easily available alternatives. Pricing hasn't been made public yet. The extra protein is a nice selling point, but not a game-changer.
What changes everything is Coke's marketing power. You'll be borbarded with ads about fairlife (small-f) until milk will run out of your eyes and ears. Bad thing? Nope. That's the only way to build awareness in today's world. (And yesterday's, for that matter. Coke figured it out a century ago.) Let's wait and see what happens when it's in every store.
Milk contains lactose. People with lactose intolerance have insufficient amounts of the enzyme lactase. Therefore, they can't digest all the lactose that's present in milk. The lactose that remains in their intestines creates the problems of diarrhea, gas, bloating, and flatulence.
This is absolutely straightforward, simple, basic digestion 101. But what if your agenda is to push the miracle of raw milk? Raw milk is milk. People with lactose intolerance can't drink it, right? Wrong. If you make up your own science, you can prove anything.
You can find this nonsense all over the Internet. Here's one example: from something called The Douglass Report, which is - get this - "Medicine's Most Notorious Myth-Buster." I can't make this stuff up.
But the natural form of lactose that’s found in real milk (i.e. raw milk) isn’t the problem. Raw milk contains an enzyme called lactase that helps your body break down and absorb the lactose. When milk is pasteurized and homogenized, though, lactase is just one of many enzymes that is killed off in the process.
That’s why most people who are lactose intolerant find that they can drink raw milk without any of the uncomfortable side effects that they typically experience when they eat or drink dairy. Raw milk still contains the lactase that helps your body properly process lactose.
Is that true? Of course not. But it sounds science-y. And hey, there's a study:
The best one I’ve found is a survey conducted by researchers in Michigan. It’s not ideal, but it’s still pretty eye opening. The Michigan researchers surveyed 155 people who had been diagnosed with lactose intolerance, 82 percent of them said didn’t experience any symptoms when they drank raw milk.
Studies are serious science, right? I mean, it would be nice to have a reference to the peer-reviewed medical journal that the study was published in, but you can't expect every little blog post to do footnotes. It's perhaps more of a problem when there was no peer-reviewed study to begin with. The Michigan researchers are the raw milk advocacy organization called the Weston A. Price Foundation. Although advocacy groups can do real research, this one doesn't. The FDA dismissed the study as being methodologically flawed.
The folks at the Weston A. Price Foundation, apparently having found out that no one who is not already a True Believer will swallow a fake "study" having as much scientific validity as one of those online "test your own IQ" sites. They hired Christopher Gardner, an associate professor of medicine at Stanford Medical School to do a real, controlled study.
Here's the result you get when you conduct a real study.
"The data fail to support our hypothesis that Raw Milk confers some benefit over Pasteurized Milk in the form of an improvement in the experience of symptoms of lactose intolerant adults."
Man, I would have loved, loved, loved to have seen their faces as Weston A. Price when they got that piece of news.
The study findings came out exactly the way any sensible person would have expected, given the known science:
[P]articipants went through three eight-day phases during which they consumed pasteurized milk, raw milk, and soy milk. Gardner notes that "the severity of the symptoms was virtually identical for the raw vs. pasteurized milk, while the symptoms of the soy milk were quite a bit, and statistically significantly, lower."
Why am I bringing this all up again? Nothing's changed, has it? Nope, nothing's changed. But the on-the-ball folks at Time magazine, the ones with the huge salaries and the unlimited research budgets, have just now noticed this study! Seriously. On Time.com on March 10, 2014, I saw this headline, Study Shows Once and for All That Raw Milk Doesn’t Help Lactose Intolerance. I thought this was so important that I needed to share the news with you. Until I read the article and discovered that it referred to the Gardner study that I reported on four years ago. And Time, Inc., doesn't do any better than the brilliant minds at the Douglass Report in giving sources, cites, times, or context.
I am not inherently against raw milk. If you can drink milk without symptoms and have a good local farm available that works tirelessly to ensure that their cattle are clean, then raw milk should be just fine for you. The battle to keep cows clean is a difficult one, which is why outbreaks of disease occur and why raw milk cannot be more than a tiny niche in the milk market. My point is smaller and simpler: there is no difference between raw milk and pasteurized milk for people who get symptoms of lactose intolerance. There is no extra lactase; there are no magic probiotics; there is nothing that will counteract the lactose that is 5% of the milk. This is not an anti-raw milk message: it is a pro-good-science message. It was true in 2010, it's true today, it will be true in 2018.
CONCLUSIONS Raw milk failed to reduce lactose malabsorption or lactose intolerance symptoms compared with pasteurized milk among adults positive for lactose malabsorption. These results do not support widespread anecdotal claims that raw milk reduces the symptoms of lactose intolerance.
I've removed some of the snarky comments from the original post, although I still feel that Time has an obligation to make some mention of sources in reporting about medical studies. And they are still invited to come here and read.
More news about better products maybe possibly hopefully some day coming to a supermarket near you.
To talk about the future, you know I'm going to start with the past and work my way there slowly. Feel free to skip a few paragraphs.
Lactase supplements were invented in 1964 by a Dutch company then known as Gist-Brocades. Happy 50th lactase! I don't know what market they were aiming for, since hardly anybody outside of a tiny community of researchers knew about the existence of lactose intolerance, but with high hopes and no fanfare whatsoever the company put out a product called Maxilact. The first Maxilact was a powder that could be added to fresh milk to break down the lactose into glucose and galactose, both simple sugars that the body can easily digest. America got introduced to lactase in the 1970s, when Alan Kligerman bought the rights and started a company now known as Lactaid. Lactase pills are now so common in every supermarket, pharmacy, and discount store that they don't really need much in the way of advertising. Same with lactose-free milks, which use a liquid solution of lactase to break down the lactose before it reaches your body. They can be found everywhere, too, with most major supermarket chains having their own house brand alongside of regional and national lactose-free milk brands.
Today lactose-free worlds is super-shiny indeed compared to the world of 1978, when I learned I was lactose intolerant. I didn't even hear about Lactaid pills until 1984. Milks arrived later, and they started as 80% or 90% lactose-reduced. True 100% lactose-free milks are newer still.
So what can be greater than 100% lactose-free milk in a dozen different varieties? How does better-tasting 100% lactose-free milk sound?
Milk that's had lactase added to it apparently has a problem, a problem named arylsulfatase. Don't feel bad if you've never heard of it. I never heard of it either and I've been studying the field for 36 years. But there it is in Elsevier's Encyclopedia of Dairy Sciences (Second Edition) from 2011. I'm sure it's a steal at $1136 for the ebook edition but fortunately this particular page is available at Google Books. Here's the science:
[T]he development of off-flavor in lactase-treated UHT (Ultra High Temperature pasteurized) milk is related to the accumulation of ρ-cresol - which when present in minute quantities leads to a severe "medical" or "animal" off-flavor. It was discovered that ther accumulation of ρ-cresol in UHT milk was due to the hydrolysis of sulfanated cresol, which is naturally present in milk, by the enzyme arylsuflanase. Arylsulfanase was introduced in the milk as a side activity in the lactase enzyme preparation, and was found to be present in all commercial neutral lactases. DSM Food-Specialties has recently selected a K. lactis strain [of the yeast used to manufacture lactase] that is devoid of arylsulfanase activity.
Who is DSM Food-Specialties? None other than the current parent company of Maxilact. It's taken a while, but Maxilact just put out a press release announcing that a European patent for this new strain of lactase has been granted.
The patent relates to a lactase enzyme, which is free from arylsulfatase. Arylsulfatase is an impurity found in lactase that converts components naturally present in milk to cause off-flavor in lactose-free dairy products, resulting in a limited shelf life. Adding arylsulfatase-free Maxilact® to a dairy formulation ensures that off-flavor development is no longer an issue and the shelf life can be extended.
Only one tiny detail remains open: This new better-tasting milk doesn't appear to exist commercially right now. Certainly not in America. Maxilact is a major player in the small community of lactase so I'm confident that somebody will start using this. Maybe we'll even see a major ad campaign about lactose-free milk, something that hasn't happened in several years.
The future: you gotta love it.
*Yeah, that was supposed to be ironic but nobody had the patience for irony in the 1980s. Besides misreading Timbuk3's catchy ditty about nuclear destruction, we also managed to hear only the first line in REM's "The One I Love" (This one goes out to the one I love/This one goes out to the one I've left behind/A simple prop to occupy my time) and make a wedding song of Sting's ode to stalkers "Every Breath You Take" ("I'll be watching you"). Seriously, an entire decade in which nobody bothered to listen to all the lyrics in a rock song. What's really ironic is that the older I get the less nostalgia I have.
Ritter Phamaceuticals is the firm founded by Andrew Ritter, who has been working to try to reduce or eliminate the symptoms of lactose Intolerance (LI) since he was a high prodigy in a science fair.
Most people here will remember him from Lactagen, a prebitiotic that worked for many and was loudly missed when it went off the market. (See Lactagen No More.)
Even before that, Ritter had started the work to test a new compound, RP-G28. (See Lactagen Prepares to File for New Drug. Whether it should be referred to as a drug is a semantic technicality that is over my head: the point to take away is that it is undergoing formal clinical testing in order to get FDA approval.)
Drug testing is a long, involved, and expensive process. Progress is being made, though. Ritter just announced through a press release that RP-G28 made it through a second successful round of tests on people.
Ritter Pharmaceuticals, Inc. today announced that Nutrition Journal has published the results of its Phase 2 trial of RP-G28, a proprietary oligosaccharide under investigation as a potential treatment for lactose intolerance. The study manuscript entitled, “Improving lactose digestion and symptoms of lactose intolerance with a novel galacto-oligosaccharide (RP-G28): a randomized, double-blind clinical trial” is the first peer-reviewed presentation of the protocol, assessments and results which showed that RP-G28 dramatically reduced the pain and symptoms of lactose intolerant patients.
Publication of this study marks a major milestone in lactose intolerance research, as it is the first well-controlled Phase 2 study for a prescription drug candidate for patients with lactose intolerance (LI). With planning underway to begin advanced clinical trials later this year, RP-G28 may become the first approved medical therapy for LI.
“The Nutrition Journal publication validates the work that has been done by our team to provide a meaningful new therapeutic approach to managing lactose intolerance symptoms, and helping millions of lactose intolerant people worldwide,” said Andrew Ritter, president and CEO of Ritter Pharmaceuticals, Inc. “The data gleaned from this study and our extensive research into colonic adaptation as a means of treating gastrointestinal disorders are being incorporated into the design of an advanced clinical program for RP-G28,” he added.
Highlights According to the publication’s results, a majority of the lactose intolerant patients who began the study with abdominal pain associated with dairy consumption reported no abdominal pain after taking RP-G28 and their symptom relief was sustained for at least one month thereafter, which is a statistically significant result. Likewise, the patients who received the study drug, compared to the ones who received placebo, were 6 times more likely to claim that, following treatment, they could consume dairy products free of lactose intolerance symptoms. See Nutrition Journal, December 13, 2013, Research section (http://www.nutritionj.com/content/12/1/160).
That link goes to the complete study, not just an abstract. A short article in more straightforward English can be found as a .pdf from the pages of the October 2013 FoodTechnology magazine by going to the link on this page.
A marketable product, if it gets FDA approval, is still years away, although Ritter appears to be farther along in its testing than Lacto-Freedom. Good news about two major products, preliminary or not, is still good news.
Google News allows you to customize a page for searchwords of your choice. I've been following all the articles that contain the words lactose or lactase for years. All stuff that I said here on the blog years ago - and in my books decades ago. Yawn.
Then yesterday, bam. A bolt of lightning. A possible new way of attacking the symptoms of lactose intolerance (LI). It's not here yet. You won't see it for years, even if the testing works - and in the real world testing often fails. I still had to share this with you.
Ken Manzo, who started Manzo Pharmaceuticals in his Shohola home, has a longer-lasting remedy in development. It's a patented, genetically modified probiotic supplement called Lacto-Freedom. Preliminary research on Manzo's invention suggests several doses of the probiotic taken during a 24-hour period will alleviate the symptoms of the food allergy for at least three months. ...
People suffering from lactose intolerance can't digest the sugar found in dairy foods, so it ferments — bubbling into acids and gases — in the large intestine.
Fermentation causes the stomachache, said Manzo, a pharmacist at Aliton's in Port Jervis. The genetically modified probiotic in Lacto-Freedom prevents the fermentation. It stays in the walls of the intestine, properly breaking down any ingested lactose, he explained.
"A regular probiotic produces some lactase," Manzo said, referring to the enzyme that breaks down lactose. "This one is way more."
Our bodies naturally make lactase in the walls of the small intestine so this mimics the way that our digestive tract should work. It's the failure to make sufficient quantities of lactase that results in the LI symptoms we all know.
Enough science. You want to know if this really works and when you can get your hands on it.Well, it works on rats in preliminary studies. The next stage is ... another rat study. Then maybe a human study. If he can get the funding.
Because this is 2014, he's got a campaign going on Medstartr, a medical version of Kickstarter. You can see it at Lacto-Freedom Probiotic. He needs to raise $50,000. By February 20, 2014. Yeah, that made me blink, too. I wish him luck, but...
A couple of other odd things popped up in the newspaper article. He worked with a a California biotechnology company on the first round of testing. That was back in 2006. Why the eight-year lag? Good question.
And that brings up the question of what Ritter Phamaceuticals, the maker of Lactagen, has been doing. Is Ritter the "California biotechnology company"? Probably not. I have news on that too, which I'll save for tomorrow's article.
As you can tell by the dates, I haven't been keeping up this blog. I started in 2005, had a stroke, and then had to restart it 2006, after I could use both hands again for typing. From that awkward beginning, though, it bloomed and ran 1500 posts for another six years.
That's a lot of posts on Lactose Intolerance (LI). I covered everything I could think of saying and then started repeating myself. I hate that. Blogs are wonderful fun when you're saying new stuff that people need to know - and a huge boring chore if you're running the same old stuff into the ground.
The Internet never forgets, so all those words are still available here. If you want them in more convenient form, I collected the really good, new stuff into a book, Planet Lactose: The Best of the Blog, volume 1. You can buy it as an ebook on Smashwords.com or Amazon.com or BarnesandNoble.com or a whole lot of other places that Smashwords is suppose to distribute the book to. Almost 100,000 words on LI, allergies, milk products, milk-free products, and the genetics of intolerance, along with large helpings of the weirdness that is the Net.
People still read this blog and some of your take the time to comment. Unfortunately, like everyone else online, spam is a problem so I moderate the comments and have to approve them before they appear. I've been doing that only about once a month so some of you have had long waits before your comments appear. I'm sorry about that. I'll try to do better in the future, but I won't promise anything.
One thing I need to emphasize. I read every comment and I post every comment that isn't spam. Every comment, even the insults. I wish the people who insult me because I stomped on their favorite form of quackery would refute me by citing a medical journal article or similar respectable source, but they never do. Just "It works" followed by an insult. You can judge the value of those comments for yourselves. Others provide actual useful information and I thank all of you.
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