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Journal of the American Society of Nephr.. by Sakaguchi, Y., Hamano, T., Wada, A... - 2w ago
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BackgroundRandomized trials of CKD treatments traditionally use clinical events late in CKD progression as end points. This requires ..read more
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BackgroundDecline in eGFR is a biologically plausible surrogate end point for the progression of CKD in clinical trials. However, it must ..read more
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BackgroundSurrogate end points are needed to assess whether treatments are effective in the early stages of CKD. GFR decline leads to ..read more
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BackgroundStudy findings show that although palliative care decreases symptom burden, it is still underused in patients with ESKD. Little ..read more
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BackgroundTRPC6 is a nonselective cation channel, and mutations of this gene are associated with FSGS. These mutations are associated with ..read more
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BackgroundThe discoidin domain receptor 1 (DDR1) is activated by collagens, upregulated in injured and fibrotic kidneys, and contributes ..read more

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