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Reduction of β-cell mass and function is central to the pathogenesis of type 2 diabetes. The terms glucotoxicity, lipotoxicity, and ..read more
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Inactivation of the β cell transcription factor NEUROD1 causes diabetes in mice and humans. In this study, we uncovered novel functions of ..read more
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Extreme obesity (EO, BMI>50) is frequently associated with neuropsychiatric disease (NPD). As both EO and NPD are heritable central ..read more
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Previously we identified plasma microRNA (miR) profiles that associate with markers of microvascular injury in diabetic nephropathy (DN) ..read more
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Epigenetic changes may contribute substantially to risks of diseases of ageing. Previous studies reported seven methylation variable ..read more
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While peripheral neuropathy is the most common complication of long-term diabetes, cognitive deficits associated with encephalopathy and ..read more
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Obesity-related insulin resistance (IR) may develop in multiple organs, representing different etiologies towards cardiometabolic diseases ..read more
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Uncoupling of mitochondrial respiration by chemical uncouplers has proven effective in ameliorating obesity, insulin resistance and ..read more
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Deficiency of endothelial progenitor cells, including endothelial colony-forming cells (ECFC) and circulating angiogenic cells (CAC), plays ..read more
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Type 2 diabetes mellitus (T2DM) patients have a considerably high risk of developing dementia, especially for those with mild cognitive ..read more

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