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Johnson & Johnson is preparing to test an experimental HIV vaccine in the U.S. and Europe in a move toward developing the first immunization against the deadly disease after decades of frustration.

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Dr. Dan Barouch accepts the Best Academic Research Team, Vaccine Industry Excellence Award, World Vaccine Congress 2019 in Washington D.C., on April 15th 2019

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“Dan Barouch, a vaccine researcher at the Harvard-affiliated Beth Israel Deaconess Medical Center in Boston, is working with Gilead to develop what's known as a "kick and kill" treatment.

The idea is to use an initial drug to flush out HIV that is hiding from the immune system and then use standard antiretrovirals to kill the newly-exposed virus. Animal studies have shown hope, but it has not yet been proven in people.

"All HIV cure approaches in general are in their infancy," he said in a telephone interview.

Rare cases of remission, such as the London and Berlin patients "provide a lot of enthusiasm and motivation" for research teams and show that a cure can be achieved, he said, "but we still have a long way to go".

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Dr. Dan Barouch discusses the challenges in designing an HIV vaccine and the ongoing clinical trials with vaccine research at BIDMC.

Click here to listen to the podcast and read more.

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“We are optimistic that an end to the HIV pandemic is feasible. However, to reach this goal, we must apply the tools and advances already at hand as we continue to follow the science in laboratories and clinics around the world. Today we honor the achievements of dedicated researchers, health care professionals, clinical trial participants and members of the global community, and we reaffirm our commitment to work together to fill the remaining gaps.”

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HIV vaccine on horizon as jab triggers immunity in humans and stops monkeys being infected “We eagerly await the results of the phase 2b Imbokodo’, which will determine whether or not this vaccine will protect humans against acquiring HIV.”

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"An HIV vaccine that has the potential to protect people around the world from the virus has shown promising results."

"These results represent an important milestone," said Dan Barouch, professor of medicine at Harvard Medical School and lead author of the study"

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Candidate AIDS vaccine passes key early test

July 6, 2018

"Although these data are promising, we need to remain cautious," study leader Dan Barouch, a Harvard Medical School professor, told AFP."This is only the fifth HIV vaccine concept that will be tested for efficacy in humans in the 35+ year history of the global HIV epidemic," added Barouch.

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"Dr. Dan Barouch, Professor of Medicine at Harvard Medical School and author of the study, told Newsweek he is “cautiously optimistic” about the results, but stressed there are many obstacles to overcome before a vaccine is rolled out for humans"

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"I would say that we are pleased with these data so far, but we have to interpret the data cautiously," said study co-author Dr. Dan H. Barouch, a principal investigator on the study, a professor of medicine at Harvard Medical School and the director of the Center for Virology and Vaccine Research. "We have to acknowledge that developing an HIV vaccine is an unprecedented challenge, and we will not know for sure whether this vaccine will protect humans."

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