AZ heroes study awarded $15M to continue, expand evaluation of COVID-19 immunity
Scienmag » Clinical Trials
by Scienmag
2y ago
A University of Arizona Health Sciences study of COVID-19 vaccine effectiveness and immunity among frontline workers has received a $15 million award from the U.S. Centers for Disease Control and Prevention (CDC) to continue the current research for another year and expand to include children and focus on underserved populations. “This phase of the AZ ..read more
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New organ-on-a-chip finds crucial interaction between blood, ovarian cancer tumors
Scienmag » Clinical Trials
by Scienmag
2y ago
Team identifies crucial interaction between platelets and tumors for the first time Credit: Texas A&M Engineering In the evolving field of cancer biology and treatment, innovations in organ-on-a-chip microdevices allow researchers to discover more about the disease outside the human body. These organs-on-chips serve as a model of the state an actual cancer patient is ..read more
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Advantages of intranasal vaccination against SARS-CoV-2
Scienmag » Clinical Trials
by Scienmag
2y ago
Intranasal vaccination is needle-free and elicits immunity at the site of infection, the respiratory tract Credit: UAB BIRMINGHAM, Ala. – There are many reasons that an intranasal vaccine against the SARS-CoV-2 virus would be helpful in the fight against COVID-19 infections, University of Alabama at Birmingham immunologists Fran Lund, Ph.D., and Troy Randall, Ph.D., write ..read more
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Phase two CD19-antibody-drug conjugate trial demonstrates promise for aggressive lymphoma
Scienmag » Clinical Trials
by Scienmag
2y ago
MUSC Hollings Cancer Center part of promising clinical trial for aggressive lymphoma Credit: MUSC Hollings Emma C. Vought MUSC Hollings Cancer Center was one of 28 clinical sites around the world that participated in the LOTIS-2 trial to test the efficacy of Loncastuximab tesirine, a promising new treatment for aggressive B-cell lymphoma. The results of ..read more
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Geneticists reveal how mutation causes childhood cancer; use drug to reverse its effects
Scienmag » Clinical Trials
by Scienmag
2y ago
Credit: Trinity College Dublin. Geneticists from Trinity College Dublin have discovered how a specific genetic mutation called H3K27M causes a devastating, incurable childhood cancer, known as diffuse midline glioma (DMG), and – in lab studies working with model cell types – successfully reverse its effects to slow cancer cell growth with a targeted drug. Their ..read more
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Existing drug is shown to inhibit SARS-CoV-2 virus
Scienmag » Clinical Trials
by Scienmag
2y ago
A new University of Chicago study has found that the drug masitinib may be effective in treating COVID-19. The drug, which has undergone several clinical trials for human conditions but has not yet received approval to treat humans, inhibited the replication of SARS-CoV-2 in human cell cultures and in a mouse model, leading to much ..read more
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New scoring system for assessing wound healing
Scienmag » Clinical Trials
by Scienmag
2y ago
Credit: Mary Ann Liebert, Inc., publishers New Rochelle, NY, July 21, 2021– Evaluating the efficacy of novel therapies requires the ability to monitor wound progression accurately and reproducibly over time. Researchers have proposed a new scoring system for wound healing in mice based on parameters in each phase of healing, as described in an article ..read more
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Precision treatment for severe asthma targets a specific mutation
Scienmag » Clinical Trials
by Scienmag
2y ago
Drug blocks a cell receptor that is mutated disproportionately in people of color Under a $10 million grant, a randomized, placebo-controlled clinical trial led by Boston Children’s Hospital will test a personalized treatment for a form of severe asthma to which Black and Latinx children and adults are especially vulnerable. Funded by the National Institute ..read more
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Novel method predicts if COVID-19 clinical trials will fail or succeed
Scienmag » Clinical Trials
by Scienmag
2y ago
Researchers first to model COVID-19 completion vs. cessation study using machine learning Credit: Florida Atlantic University/College of Engineering and Computer Science In order to win the battle against COVID-19, studies to develop vaccines, drugs, devices and re-purposed drugs are urgently needed. Randomized clinical trials are used to provide evidence of safety and efficacy as well ..read more
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Research shows employer-based weight management program with access to anti-obesity medications results in greater weight loss
Scienmag » Clinical Trials
by Scienmag
2y ago
Clinical trial was conducted in the real-world setting of a workplace health plan Tuesday, July 20, 2021, CLEVELAND: A Cleveland Clinic study demonstrates that adults with obesity lost significantly more weight when they had access to medications for chronic weight management in conjunction with their employer-based weight management program, compared to adults who did not ..read more
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