Journal of Allergy and Clinical Immunology
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The Journal of Allergy and Clinical Immunology is the official publication of the American Academy of Allergy, Asthma, and Immunology.
Journal of Allergy and Clinical Immunology
1d ago
Immunoglobulin E, IgE)-mediated degranulation of mast cells, MCs) provides rapid protection against environmental hazards, including animal venoms. A fraction of tissue-resident MCs intimately associates with blood vessels. These perivascular MCs were reported to extend projections into the vessel lumen and to be the first MCs to acquire intravenously injected IgE, suggesting that IgE loading of MCs depends on their vascular association ..read more
Journal of Allergy and Clinical Immunology
1w ago
Despite the promise of oral immunotherapy (OIT) to treat food allergies, this procedure is associated with potential risk. There is no current agreement about what elements should be included in the preparatory or consent process ..read more
Journal of Allergy and Clinical Immunology
1w ago
The recent approval of omalizumab for the treatment of IgE-mediated food allergy is an important step forward for the millions of food allergy patients in the US. Through the depletion of circulating IgE and the subsequent reduction of FCεR1 on key effector cells, patients increase their tolerance to food allergens. However, omalizumab does not permit patients to eat foods that they are allergic to with impunity. Rather, it protects them from most accidental exposures. In addition, omalizumab does not cure food allergy and has not demonstrated true immunomodulation ..read more
Journal of Allergy and Clinical Immunology
1w ago
Journal of Allergy and Clinical Immunology
1w ago
Journal of Allergy and Clinical Immunology
1w ago
Journal of Allergy and Clinical Immunology
1w ago
Journal of Allergy and Clinical Immunology
1w ago
Journal of Allergy and Clinical Immunology
1w ago
With regard to the article in the April 2022 issue entitled “Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome” (J Allergy Clin Immunol 2022;151:1081-95), author Eleonora Gambineri would like to update her affiliations to read: Department of NEUROFARBA, Section of Children's Health, University of Florence, Florence, Italy; and Centre of Excellence, Division of Pediatric Oncology/Hematology, Meyer Children’s Hospital IRCCS, Florence, Italy ..read more
Journal of Allergy and Clinical Immunology
1w ago
Janus kinase 1 (JAK1) is critical for type 2 cytokine signaling, and gain-of-function JAK1 mutations are associated with multiple chronic allergic disorders. Tamari et al (Cell 2024;187:44-61.e17; https://doi.org/10.1016/j.cell.2023.11.027) examined the tissue-specific immunoregulatory roles of JAK1 signaling. Spontaneous allergic inflammation was observed in the skin, but not the lungs, of mice containing a pathogenic human JAK1 gain-of-function variant. Moreover, the JAK1 gain-of-function variant protected against allergen-induced airway inflammation ..read more