The Journal of Physiology
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The Journal of Physiology publishes original Research Papers in all areas of physiology and pathophysiology illustrating new physiological principles or mechanisms. Papers on work at the molecular level, cell membrane, single cells, tissues or organs and on systems physiology are all encouraged.
The Journal of Physiology
12h ago
Abstract figure legend Ionic mechanisms of ventricular fibrillation (VF) recurrence post-shock during cardiopulmonary resuscitation (CPR).
Abstract
Defibrillation remains the optimal therapy for terminating ventricular fibrillation (VF) in out-of-hospital cardiac arrest (OHCA) patients, with reported shock success rates of ∼90%. A key persistent challenge, however, is the high rate of VF recurrence (∼50–80%) seen during post-shock cardiopulmonary resuscitation (CPR). Studies have shown that the incidence and time spent in recurrent VF are negatively associated with neurologically-intact surv ..read more
The Journal of Physiology
2d ago
Abstract figure legend Ischaemia is a major cause of lower urinary tract symptoms (LUTS), but ischaemic dysfunction is less prevalent in the urethra than in the bladder. In the bladder, sympathetic overdrive associated with ageing or metabolic syndrome would constrict arteries/arterioles resulting in blood flow reduction. In the urethra, parasympathetic and sensory nerves well counteract sympathetic vasoconstriction to minimise blood flow reduction. NO released from parasympathetic nerves diminishes sympathetic transmitter release, while directly relaxing arteriolar smooth muscle cells. Acety ..read more
The Journal of Physiology
3d ago
Abstract figure legend There are several lines of evidence from the rodent hippocampus that theta frequency oscillations (4–12 Hz) are rich in distal strata, while ripples (120–250 Hz) are prominent in strata that are within and around the pyramidal cell layer. Our goal here was to explore possible co-occurrence of these distinct bands of signals with differential distribution across strata. We simultaneously recorded extracellular signals from multiple strata in the hippocampus of foraging rats using multi-site silicon polytrodes. We identified theta epochs from extracellular signa ..read more
The Journal of Physiology
6d ago
Abstract figure legend Comparative analysis of mechanosensitive ion channels in mouse tissue-resident and bone marrow-derived macrophages. mRNA coding for the mechanosensitive ion channels Piezo1 and TRPV4 is found in both types of macrophages. Piezo1 activity is observed in the plasma membrane of bone marrow-derived macrophages, but not in the membrane of macrophages isolated from heart tissue while TRPV4 activity is found across the macrophage types studied.
Abstract
Macrophages (MΦ) play pivotal roles in tissue homeostasis and repair. Their mechanical environment has been identified as a ..read more
The Journal of Physiology
6d ago
The Journal of Physiology, Volume 602, Issue 8, Page 1443-1444, 15 April 2024 ..read more
The Journal of Physiology
1w ago
Abstract figure legend Short- and long-latency afferent inhibition are evoked by pairing single-pulse transcranial magnetic stimulation (TMS) with peripheral nerve stimulation. Participants received levodopa (l-DOPA) and Placebo on separate sessions. SAI was increased in the presence of L-DOPA but not Placebo.
Abstract
Short- and long-latency afferent inhibition (SAI and LAI respectively) are phenomenon whereby the motor evoked potential induced by transcranial magnetic stimulation (TMS) is inhibited by a sensory afferent volley consequent to nerve stimulation. It remains unclear whether dop ..read more