Ergothioneine dosing, Part 2
Surface Your Real Self | Epigenetics
by gettingwell4
1w ago
Continuing Part 1 with a 2024 rodent healthspan and lifespan study: “We investigated the effects of daily oral supplementation of ergothioneine (ERGO) dissolved in drinking water on lifespan, frailty, and cognitive impairment in male mice from 7 weeks of age to the end of their lives. Ingestion of 4 ~ 5 mg/kg/day of ERGO remarkably extended the ..read more
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Sulforaphane’s effects on autism and liver disease
Surface Your Real Self | Epigenetics
by gettingwell4
1M ago
Here are two more papers that cited Precondition your defenses with broccoli sprouts, starting with a 2024 human / rodent study investigating gut microbiota / sulforaphane’s effects on autism: “Sulforaphane (SFN) has been found to alleviate complications linked with several diseases by regulating gut microbiota (GM), while the effect of GM on SFN for autism ..read more
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Improving peroxisomal function
Surface Your Real Self | Epigenetics
by gettingwell4
2M ago
A 2024 review provided details about “mysteries” in peroxisome research: “Peroxisomes are key metabolic organelles with essential functions in cellular lipid metabolism (e.g., β-oxidation of fatty acids and synthesis of ether phospholipids, which contribute to myelin sheath formation), and metabolism of reactive oxygen species (ROS), particularly hydrogen peroxide. Loss of peroxisomal function causes severe metabolic ..read more
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Get a little stress into your life
Surface Your Real Self | Epigenetics
by gettingwell4
2M ago
Two reviews on beneficial effects of mild stress, starting with a 2024 paper coauthored by the lead researcher of Sulforaphane in the Goldilocks zone: “This paper addresses how long lifespan can be extended via multiple interventions, such as dietary supplements, pharmaceutical agents, caloric restriction, intermittent fasting, exercise, and other activities. This evaluation was framed within ..read more
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Taurine’s effects on healthspan and lifespan, Part 2
Surface Your Real Self | Epigenetics
by gettingwell4
2M ago
Four 2023 papers that cited Part 1, starting with a review of hypothetical parameters for taurine clinical trials that aren’t going to happen because: Drug companies can’t make money from a research area that’s cheap, not patentable, and readily accessible. Government sponsors are likewise not incentivized to act in the public’s interest per their recent ..read more
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Take acetyl-L-carnitine if you are healthy
Surface Your Real Self | Epigenetics
by gettingwell4
3M ago
Eight 2023 acetyl-L-carnitine / L-carnitine papers, starting with three healthy human studies: “Thirty healthy volunteers aged between 19 and 52 years were divided randomly into two equal groups, one of which received 1000 mg of L-carnitine (LC) per day over a 12-week period. Total cholesterol and HDL-C increased significantly after supplementation. LC could be useful ..read more
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Oat sprout stressors
Surface Your Real Self | Epigenetics
by gettingwell4
3M ago
Two 2023 Avena sativa oat sprout studies, starting with one that found different effects during germination from varying temperature and relative humidity: “This study evaluated effects of temperature (20, 25, and 30°C) and relative humidity (RH, 50, 55, and 60%) as abiotic stressors during oat germination. We identified eighty polyphenols, nine avenanthramides, twelve lignans, and ..read more
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What you expect may not be what you find
Surface Your Real Self | Epigenetics
by gettingwell4
3M ago
I’m halfway through a 90-day trial of plasmalogens coincident with improving peroxisomal function via resistance exercise and time-restricted eating. I haven’t curated related 2023 papers I’ve read concerning plasmalogens, peroxisomes, sphingolipids, ceramides, and mitochondrial interactions with these, mainly because I haven’t seen human-pertinent aspects similar to Dr. Goodenowe’s efforts. The 2023 papers I’ve read have ..read more
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Building your plasmalogen savings account
Surface Your Real Self | Epigenetics
by gettingwell4
3M ago
A webinar from earlier this week with Dr. Goodenowe, a clinical trial facilitator, and a physician: From the Q&A segment: “Is there a particular age where it’s recommended to test for plasmalogen levels? And what levels would be considered normal? That’s a good question. That actually raises this whole concept of optimal health and this ..read more
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What is the health utility of white blood cell type count ratios?
Surface Your Real Self | Epigenetics
by gettingwell4
4M ago
This post explores CBC ratios of neutrophils-to-lymphocytes (NLR) and lymphocytes-to-monocytes (LMR) as healthy biomarkers. Uses of the neutrophils-to-lymphocytes ratio asserted: A normal range of NLR is between 1–2, and values higher than 3.0 and below 0.7 in adults are pathological. I saw only one study out of 151 references, reference 61 from 2017, that demonstrated ..read more
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