Peritoneal Malignant Mesothelioma Metastasizing to Lymph Node in Young Male-a Case Report
Mesothelioma Line | Journal Articles on Mesothelioma: Cancer Information for Patients and Families
by Steven Chervenick
2d ago
Indian Journal of Surgical Oncology 2024 March [Link] Amanpreet Singh, Cherry Bansal, Disha Singla, Sarika More, Shivani Chabhra, Shazia Bashir Abstract Peritoneal malignant mesothelioma is an uncommon neoplasm with a poor prognosis. We hereby report a case of a 20-year-old male, first diagnosed on biopsy with axillary lymph node metastasis. He presented with abdominal pain and axillary lymphadenopathy, with no history of asbestos exposure. CECT showed peritoneal thickening and ascites. Ascitic fluid cytology showed reactive morphology. The diagnosis of metastatic deposits of malignant mesothe ..read more
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Complex Genomic Rearrangement Patterns in Malignant Pleural Mesothelioma due to Environmental Asbestos Exposure
Mesothelioma Line | Journal Articles on Mesothelioma: Cancer Information for Patients and Families
by Steven Chervenick
2d ago
Journal of Environmental Pathology, Toxicology, and Oncology 2024 [Link] Tunç Tuncel, Güntülü Ak, Hasan Veysi Güneş, Muzaffer Metintaş Abstract Malignant pleural mesothelioma (MPM) is a rare type of cancer, and its main risk factor is exposure to asbestos. Accordingly, our knowledge of the genomic structure of an MPM tumor is limited when compared to other cancers. In this study, we aimed to characterize complex genomic rearrangement patterns and variations to better understand the genomics of MPM tumors. We comparatively scanned 3 MPM tumor genomes by Whole-Genome Sequencing and High-Resoluti ..read more
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Immune modulation in malignant pleural effusion: from microenvironment to therapeutic implications
Mesothelioma Line | Journal Articles on Mesothelioma: Cancer Information for Patients and Families
by Steven Chervenick
4d ago
Cancer Cell International 2024 March 12 [Link] Shan Ge, Yuwei Zhao, Jun Liang, Zhongning He, Kai Li, Guanghui Zhang, Baojin Hua, Honggang Zheng, Qiujun Guo 2, Runzhi Qi, Zhan Shi Abstract Immune microenvironment and immunotherapy have become the focus and frontier of tumor research, and the immune checkpoint inhibitors has provided novel strategies for tumor treatment. Malignant pleural effusion (MPE) is a common end-stage manifestation of lung cancer, malignant pleural mesothelioma and other thoracic malignancies, which is invasive and often accompanied by poor prognosis, affecting the qualit ..read more
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A gene signature linked to fibroblast differentiation for prognostic prediction of mesothelioma
Mesothelioma Line | Journal Articles on Mesothelioma: Cancer Information for Patients and Families
by Steven Chervenick
6d ago
Cell & Bioscience 2024 March 10 [Link] Jun Liu, Yuwei Lu, Yifan Liu, Wei Zhang, Shuyuan Xian, Siqiao Wang, Zixuan Zheng, Ruoyi Lin, Minghao Jin, Mengyi Zhang, Weijin Qian, Jieling Tang, Bingnan Lu, Yiting Yang, Zichang Liu, Mingyu Qu, Haonan Ma, Xinru Wu, Zhengyan Chang, Jie Zhang, Yuan Zhang Abstract Background: Malignant mesothelioma is a type of infrequent tumor that is substantially related to asbestos exposure and has a terrible prognosis. We tried to produce a fibroblast differentiation-related gene set for creating a novel classification and prognostic prediction model of MESO. Meth ..read more
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Pleural mesothelioma (PMe): The evolving molecular knowledge of a rare and aggressive cancer
Mesothelioma Line | Journal Articles on Mesothelioma: Cancer Information for Patients and Families
by Steven Chervenick
6d ago
Molecular Oncology 2024 March 8 [Link] Manuel Rigon, Luciano Mutti, Michelangelo Campanella Abstract Mesothelioma is a type of late-onset cancer that develops in cells covering the outer surface of organs. Although it can affect the peritoneum, heart, or testicles, it mainly targets the lining of the lungs, making pleural mesothelioma (PMe) the most common and widely studied mesothelioma type. PMe is caused by exposure to fibres of asbestos, which when inhaled leads to inflammation and scarring of the pleura. Despite the ban on asbestos by most Western countries, the incidence of PMe is on the ..read more
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UV1 telomerase vaccine with ipilimumab and nivolumab as second line treatment for pleural mesothelioma – A phase II randomised trial
Mesothelioma Line | Journal Articles on Mesothelioma: Cancer Information for Patients and Families
by Steven Chervenick
1w ago
European Journal of Cancer 2024 March 1 [Link] Vilde Drageset Haakensen, Åsa Kristina Öjlert, Solfrid Thunold, Saima Farooqi, Anna K Nowak, Wee L Chin, Oscar Grundberg, Weronika Maria Szejniuk, Susana Cedres, Jens Benn Sørensen, Tonje Sofie Dalen, Marius Lund-Iversen, Maria Bjaanæs, Åslaug Helland Abstract Purpose: The NIPU-trial investigates the effect of adding the telomerase vaccine UV1 to treatment with ipilimumab and nivolumab for patients with pleural mesothelioma (PM). Methods: In this phase 2 open-label trial, patients with PM progressing after first-line chemotherapy were randomised t ..read more
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Successful treatment of simultaneous malignant pleural mesothelioma and pulmonary adenocarcinoma: A case report
Mesothelioma Line | Journal Articles on Mesothelioma: Cancer Information for Patients and Families
by Steven Chervenick
1w ago
Oncology Letters 2024 February 15 [Link] Yuki Amakusa, Tatsuro Suzuki, Yu Hikosaka, Masaya Takemura, Tetsuya Oguri Abstract The present report described the case of a 74-year-old male patient with asbestos exposure whose chest computed tomography revealed a right lower lobe nodule and right pleural effusion. Pleural biopsy led to the diagnosis of epithelial malignant pleural mesothelioma (cT2N0M0, stage IB). Combination therapy with cisplatin + pemetrexed led to the complete remission of malignant pleural mesothelioma; however, the right lower lobe nodule grew in size over time. The patient wa ..read more
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The highly selective and oral phosphoinositide 3-kinase delta (PI3K-δ) inhibitor roginolisib induces apoptosis in mesothelioma cells and increases immune effector cell composition
Mesothelioma Line | Journal Articles on Mesothelioma: Cancer Information for Patients and Families
by Steven Chervenick
2w ago
Translational Oncology 2024 May [Link] Claudia Kalla, German Ott, Francesca Finotello, Karolina Niewola-Staszkowska, Giusy Di Conza, Michael Lahn, Lars van der Veen, Julia Schüler, Roger Falkenstern-Ge, Joanna Kopecka, Chiara Riganti Abstract Targeting aberrantly expressed kinases in malignant pleural mesothelioma (MPM) is a promising therapeutic strategy. We here investigated the effect of the novel and highly selective Phosphoinositide 3-kinase delta (PI3K-δ) inhibitor roginolisib (IOA-244) on MPM cells and on the immune cells in MPM microenvironment. To this aim, we analyzed the expression ..read more
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The genetic susceptibility in the development of malignant pleural mesothelioma: somatic and germline variants, clinicopathological features and implication in practical medical/surgical care: a narrative review
Mesothelioma Line | Journal Articles on Mesothelioma: Cancer Information for Patients and Families
by Steven Chervenick
2w ago
Journal of Thoracic Disease 2024 January 30 [Link] Maria Teresa Congedo, Elizabeth Casey West, Jessica Evangelista, Aubrey Anne Mattingly, Giuseppe Calabrese, Carolina Sassorossi, Adriana Nocera, Marco Chiappetta, Sara Flamini, Ludovico Abenavoli, Stefano Margaritora, Luigi Boccuto, Filippo Lococo Abstract Background and objective: Malignant pleural mesothelioma (MPM) is a very aggressive primary tumor of the pleura whose main risk factor is exposure to asbestos. However, only a minority of exposed people develops MPM and the incidence of MPM cases without an apparent association with asbestos ..read more
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The Impact of 3D Nichoids and Matrix Stiffness on Primary Malignant Mesothelioma Cells
Mesothelioma Line | Journal Articles on Mesothelioma: Cancer Information for Patients and Families
by Steven Chervenick
2w ago
Genes 2024 February 1 [Link] Stefania Oliveto, Paolo Ritter, Giorgia Deroma, Annarita Miluzio, Chiara Cordiglieri, Mauro Roberto Benvenuti, Luciano Mutti, Manuela Teresa Raimondi, Stefano Biffo Abstract Malignant mesothelioma is a type of cancer that affects the mesothelium. It is an aggressive and deadly form of cancer that is often caused by exposure to asbestos. At the molecular level, it is characterized by a low number of genetic mutations and high heterogeneity among patients. In this work, we analyzed the plasticity of gene expression of primary mesothelial cancer cells by comparing the ..read more
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