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A rare case of neuroendocrine cell tumor mixed with a mucinous component in the ampulla of Vater

BioMed Central » Diagnostic Pathology

by Tamotus Sugai, Noriyuki Uesugi, Masamichi Suzuki, Nobuyasu Suzuki, Michitaka Honda, Tsuyoshi Abe and Naoki Yanagawa

5d ago

A rare case of neuroendocrine cell tumor (NET) having both conventional and mucinous components was reported. Mucinous NET is rarely encountered in the pathological diagnosis of gastrointestinal (GI) tumors. H ..read more

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Low-grade undifferentiated sarcoma with MEIS1::NCOA2-rearrangement primary to the lung: a case report

BioMed Central » Diagnostic Pathology

by Zachary Coty-Fattal, Bianca Carter, Michael J. Volek and Farres Obeidin

5d ago

MEIS1::NCOA2 is a rare fusion gene that has been recently described in a subset of spindle cell rhabdomyosarcomas and multiple low-grade undifferentiated spindle cell sarcomas predominantly arising in the genitou ..read more

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Squamous cell carcinoma initially occurring on the tongue dorsum: a case series report with molecular analysis

BioMed Central » Diagnostic Pathology

by Sawako Ono, Katsutoshi Hirose, Shintaro Sukegawa, Kyoichi Obata, Masanori Masui, Kazuaki Hasegawa, Ai Fujimura, Katsumitsu Shimada, Satoko Nakamura, Akari Teramoto, Yumiko Hori, Eiichi Morii, Daisuke Motooka, Takuro Igawa, Takehiro Tanaka, Hitoshi Nagatsuka…

5d ago

Squamous cell carcinoma (SCC) of the dorsum of the tongue is extremely rare, and it clinically resembles various benign lesions. Somatic mutations in TP53 and some driver genes were implicated in the development ..read more

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An unusual case of primary splenic soft part alveolar sarcoma: case report and review of the literature with emphasis on the spectrum of TFE3-associated neoplasms

BioMed Central » Diagnostic Pathology

by René Guérin, Anne-Lise Menard, Emilie Angot, Nicolas Piton, Pierre Vera, Lilian Schwarz, Jean-Christophe Sabourin, Marick Laé and Pierre-Alain Thiébaut

1w ago

Alveolar soft part sarcoma is a rare tumour of soft tissues, mostly localized in muscles or deep soft tissues of the extremities. In rare occasions, this tumour develops in deep tissues of the abdomen or pelvis ..read more

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A case of pancreatic PEComa with prominent inflammatory cell infiltration: the inflammatory subtype is a distinct histologic group of PEComa

BioMed Central » Diagnostic Pathology

by Hikaru Tsukita, Kei Koyama, Takahiro Ishinari, Ayana Takahashi, Ken Miyabe, Michinobu Umakoshi, Makoto Yoshida, Yukitsugu Kudo-Asabe, Akiko Nishida, Naohiko Otsuka, Ouki Yasui, Ikuma Kato, Noriyoshi Fukushima and Akiteru Goto

2w ago

PEComa is a mesenchymal tumor that can occur in various organs including the uterus and soft tissues. PEComas are composed of perivascular epithelioid cells, and angiomyolipoma (AML), clear cell sugar tumor (C ..read more

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Development of crizotinib-associated renal cyst in a non-small cell lung cancer patient with ALK fusion: a case report and review of the literature

BioMed Central » Diagnostic Pathology

by Peng Zhang, JiaHua Xu, Qing Wu, Jianxin Qian and Song Wang

2w ago

Crizotinib, an oral first-generation tyrosine kinase inhibitor (TKI), is superior to systemic chemotherapy for the treatment of non-small cell lung cancer (NSCLC) with positive rearrangement of anaplastic lymp ..read more

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Clinicopathological analysis of 22 Müllerian adenosarcomas and the sequencing of DICER1 mutation

BioMed Central » Diagnostic Pathology

by Xiaohong Yao, Wei Wang and Ying He

1M ago

Müllerian adenosarcoma, a rare malignancy, presents diagnostic and therapeutic challenges. In this study, we conducted an analysis of the clinicopathological characteristics of 22 adenosarcomas, with a particu ..read more

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Concurrent KRAS p.G12C mutation and ANK3::RET fusion in a patient with metastatic colorectal cancer: a case report

BioMed Central » Diagnostic Pathology

by Tillmann Bedau, Carina Heydt, Udo Siebolts, Thomas Zander, Max Kraemer, Heike Loeser, Reinhard Buettner and Alexander Quaas

1M ago

Colorectal cancer (CRC) frequently involves mutations in the KRAS gene, impacting therapeutic strategies and prognosis. The occurrence of KRAS mutations typically precludes the presence of RET fusions, with curre ..read more

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Comprehensive evaluation of the relationship between biomarker profiles and neoadjuvant chemotherapy outcomes for breast cancer patients

BioMed Central » Diagnostic Pathology

by Mijia Wang, Zhendong Wei, Jixia Kong and Haidong Zhao

1M ago

Accurately predicting the response to neoadjuvant chemotherapy (NAC) in breast cancer patients is crucial for guiding treatment strategies and enhancing clinical outcomes. Current studies have primarily focuse ..read more

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Extradural spinal melanoma: is it primary or metastatic? A case report with a brief review of literature

BioMed Central » Diagnostic Pathology

by Raghav Kapoor, Anurag Mehta, Anila Sharma, Shrinidhi Nathany, Himanshi Diwan and Divya Bansal

1M ago

Melanocytic lesions involving the central nervous system are extremely rare and pose a diagnostic challenge owing melanoma being the third most common malignancy metastasizing to the spine. Morphology and immu ..read more

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