Kartik, Denise, and Gorka join TWiV to discuss their finding that changes in the surface glycoprotein of South American yellow fever virus lead to reduced neutralization by antibodies induced by the vaccine, which is derived from an African isolate. Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker Guests: Kartik Chandran, Denise Haslwanter, and Gorka Lasso Cabrera Click arrow to play Download TWiV 893 (65 MB .mp3, 108 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS,  Become a patron of TWiV! Links for this episode Pr ..read more

In COVID-19 clinical update #111, Dr. Griffin discusses vaccine coverage and mortality in Hong Kong, immune response to boosters in kids, hospitalization of kids, breath based diagnostic test, viral co-infections, bivalent mRNA vaccine, intramuscular Evusheld, and global long COVID. Click arrow to play Download TWiV 892 (33 MB .mp3, 54 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS,  Become a patron of TWiV! Links for this episode Vaccine coverage and mortality, Hong Kong (MMWR) Kids behind on routine vaccinations (Politico) Immune respons ..read more

Elke, Adam, and Gabor join TWiV to discuss their work on Lloviu virus, a filovirus, including recovery of infectious virus from a DNA copy of the genome and from Schreiber’s bats in Hungary. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guests: Elke Muhlberger, Adam Hume, and Gabor Kemenesi Click arrow to play Download TWiV 891 (65 MB .mp3, 108 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS,  Become a patron of TWiV! Links for this episode Elke on TWiV 200 and Threading the NEIDL Infectious Lloviu virus ..read more

This episode of TWiV is focused on COVID-19 vaccines and antibodies: who should get boosters, whether a variant matched mRNA vaccine is superior to a historical vaccine, and how the interval between vaccination and infection influences the quality of the antibody response. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Click arrow to play Download TWiV 888 (65 MB .mp3, 108 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS,  Become a patron of TWiV! Links for this episode What next for COVID-19 boosters ..read more

In COVID-19 clinical update #110, Dr. Griffin covers hospital admissions during variant outbreaks, viral load in vaccinated and unvaccinated individuals, predictive capacity of symptoms in children, comparison of antigen tests, incidence of myocarditis after vaccination, steroids during replication phase, Paxlovid efficacy and safety, fluvoxamine, sabizabutin, colchicine, and prevalence of infection in Africa. Click arrow to play Download TWiV 889 (52 MB .mp3, 53 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS,  Become a patron of TWiV! Lin ..read more

Richard joins TWiV to discuss the SARS-CoV-2 antiviral drug Molnupiravir , including how it was discovered, its mechanism of action, whether it is a mutagen for cells, and the future of drugs for treatment of COVID-19. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Guest: Richard Plemper Click arrow to play Download TWiV 888 (65 MB .mp3, 108 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS,  Become a patron of TWiV! Links for this episode Richard on TWiV 636 Molnupiravir in ferrets (Nat Micro) Oral prodrug of Remdesivir in f ..read more

TWiV explains why this season’s influenza vaccine is not protecting against mild to moderate disease caused by H3N2 virus, and that antibody-dependent entry of SARS-CoV-2 into monocytes is a major contributor to severe COVID-19. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld Click arrow to play Download TWiV 887 (65 MB .mp3, 108 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS,  Become a patron of TWiV! Links for this episode Seasonal influenza vaccine effectiveness (MMWR) Properties of a dominant H3N2 v ..read more

In COVID-19 clinical update #109, Daniel Griffin discusses cardiac complications after infection or vaccination, long COVID in children, fourth vaccine dose in Israel, no need for fourth vaccine does in EU, dexamethasone dosing, immunomodulation therapy, MIS outcomes in children, US long COVID effort launched, and herd immunity. Click arrow to play Download TWiV 886 (27 MB .mp3, 45 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS,  Become a patron of TWiV! Links for this episode Cardiac complications after infection or vaccination (MMWR) Lo ..read more

TWiV reveals an ACE2-dependent sarbecovirus from Russian bats that is not inhibited by anti-SARS-CoV-2 antibodies, and a modified vaccinia virus Ankara vectored vaccine that protects nonhuman primates from Delta infection. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Click arrow to play Download TWiV 885 (73 MB .mp3, 122 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS,  Become a patron of TWiV! Links for this episode Sarbecovirus from Russian bat (bioRxiv) 1:33 MVA vectored COVID vaccine (Sci Immunol) 30:19 Letters read ..read more

Vincent and Amy explain how asthmatic bronchial smooth muscle increases rhinovirus replication in the bronchial epithelium, and mimicry of IL-17 by the ORF8 protein of SARS-CoV-2. Hosts: Vincent Racaniello and Amy Rosenfeld Click arrow to play Download TWiV 884 (73 MB .mp3, 122 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS,  Become a patron of TWiV! Links for this episode Asthmatic bronchial smooth muscle and rhinovirus (Cell Rep) SARS-CoV-2 ORF8 mimics IL-17 (mBio) Letters read on TWiV 884 Timestamps by Jolene. Thanks! Weekly Pic ..read more