In a nutshell This study evaluated the effectiveness and safety of TAS-102 (Lonsurf; trifluridine-tipiracil) plus Yttrium-90 (Y-90) radioembolization (RE) for patients with colorectal cancer liver metastasis (CRLM) who are unresponsive to chemotherapy. The data showed that TAS-102 plus RE was safe and effective in these patients. Some background Colorectal cancer (CRC) is one of the most common types of cancer worldwide. The first choice for the treatment of CRC is usually surgery. In 50% of the cases, cancer spreads to the liver known as CRLM. Less than 20% of these patients are eligible ..read more

In a nutshell This study evaluated the effectiveness and safety of panitumumab (Vectibix) rechallenge when added to maintenance therapy with FOLFIRI {fluorouracil (FU; Adrucil), folinic acid (FA; Leucovorin), irinotecan (Camptosar)} in patients with RAS wild-type metastatic colorectal cancer (mCRC). The data showed that maintenance therapy with panitumumab plus FOLFIRI was effective with manageable side effects in these patients. Some background Patients who are diagnosed with mCRC have disease that has spread to other areas. Genetic changes in KRAS protein can often occur to promote ..read more

In a nutshell This study evaluated the effectiveness of chemotherapy before surgery for the treatment of patients with resectable colorectal cancer liver metastasis (CRLM). The data showed that the addition of chemotherapy before surgery significantly improved disease-free survival (survival without any signs or symptoms of cancer) but not the overall survival in these patients. Some background Colorectal cancer (CRC) is one of the most common types of cancer worldwide. The first choice for the treatment of CRC is usually surgery. In 50% of the cases, cancer spreads to the liver ..read more

In a nutshell This study evaluated the effectiveness and safety of robotic versus laparoscopic abdominoperineal resections (APRs) for the treatment of patients with low rectal cancer (RC). The data showed that robotic APRs significantly reduced surgical trauma and promoted recovery after surgery compared with laparoscopic APRs in these patients. Some background Rectal cancer (RC) is one of the most common types of cancer worldwide. RC involves the final part of the large intestine or rectum. A low rectal cancer is one that is close to the anus. Low RC can be treated by surgical removal of ..read more

In a nutshell This study evaluated the effectiveness and safety of FOLFOXIRI (fluorouracil, leucovorin, oxaliplatin, and irinotecan) plus bevacizumab (Avastin) with or without atezolizumab (Tecentriq) on the outcomes of patients with metastatic (m) colorectal cancer (CRC). The study showed that adding atezolizumab to FOLFOXIRI plus bevacizumab regimen was safe and improved survival outcomes in these patients. Some background Colorectal cancer (CRC) is one of the most common types of cancer worldwide. The early symptoms of CRC are often not reported. Patients a ..read more

In a nutshell This study evaluated the effectiveness and safety of transanal (ta) versus laparoscopic (lap) total mesorectal resection (TME) for the treatment of patients with stage I-III rectal cancer (RC). The data showed that experienced surgeons can safely perform taTME in these patients. Some background Rectal cancer (RC) is one of the most common types of cancer worldwide. RC involves the final part of the large intestine or rectum. The standard treatment for RC is usually surgery. Complete removal of the tumor is called total mesorectal excision (TME). There are different types of s ..read more

In a nutshell The study evaluated the effectiveness of massage therapy for chemotherapy-induced peripheral neuropathy (CPIN) in patients with breast and gastrointestinal (GI) cancer. The main finding of the study was that intensive massage therapy 3 times a week showed promising results in these patients.  Some background There are many cancer treatments that cause neurologic toxicity such as CIPN. CIPN consists of symptoms that occur due to damage to the peripheral nerves. CIPN symptoms include pain, burning, numbness, and tingling sensations. The severity of CIPN depends on the type ..read more

In a nutshell This study evaluated the health-related quality of life (HR-QoL) outcomes of second-line chemotherapy combined with either bevacizumab (Avastin) or with cetuximab (Erbitux) in patients with advanced colorectal cancer with wild-type KRAS. This study concluded that the HR-QoL outcomes were similar with both treatments in these patients. Some background Metastatic colorectal cancer (mCRC) means the cancer has spread from the large intestine to other areas of the body. Genetic changes in the KRAS protein can often occur to promote mCRC growth and spread. mCRC ..read more

In a nutshell This study evaluated the long-term effectiveness and safety of 3-month versus 6-month modified FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin) or CAPOX (capecitabine and oxaliplatin) treatment after surgery in patients with stage 3 colon cancer. The data showed that 3-month modified FOLFOX/CAPOX treatment was as effective and safe as the 6-month treatment over the long term in these patients. Some background Colorectal cancer (CRC) is one of the most common types of cancer worldwide. CRC involves the final part of the large intestine, colon, or rectum. The first choice f ..read more

In a nutshell This study evaluated the effectiveness and safety of adding PolyPepI1018 peptide vaccine to fluoropyrimidine/bevacizumab (Avastin) maintenance therapy in patients with microsatellite stable (MSS) metastatic colorectal cancer (mCRC). The data showed that PolyPEPI1018 added to maintenance therapy was safe and associated with specific immune responses and antitumor activity in these patients. Some background Colorectal cancer (CRC) is one of the most common types of cancer worldwide. Some patients do not report symptoms with the initial tumor. These patients are often only ..read more