Relapses in a common form of leukemia may be preventable following new research that has identified how the cancer develops resistance to first line treatments ..read more

Scientists discovered which tumor cells resist treatment and why. By characterizing B-cells' developmental stages, they designed and tested a drug combination to effectively treat resistant B-cell leukemia ..read more

New research has found that venetoclax, a medication currently approved for leukemia, has benefits for patients with multiple myeloma when used in combination with another drug. This discovery offers a new avenue of treatment options for the currently incurable disease ..read more

Researchers have discovered that a specific mutation in the cancer cells of an aggressive type of blood cancer can prevent novel immunotherapies such as CAR T-cell therapy from working. Their study also explains why the cancer cells are resistant and how this resistance can be overcome: through concomitant pharmacotherapy or genetically improved CAR T-cells ..read more

Imagine being able to count the different types of blood cells being formed inside the tiny bones of a mouse and pinpointing the strings and clusters of cells within the bone marrow that are responsible for producing specific types of blood cells. That's exactly what a team of scientists achieved in a far-reaching study. Among the potential applications: developing artificial 'bones' that could produce specific types of blood cells ..read more

For some leukemia patients, their only treatment option carries a risk of heart failure ..read more

Treatment with a molecule known as A485 can quickly and temporarily increase levels of white blood cells, a critical part of the body's immune system, an effect that is difficult to deliver with currently available pharmaceuticals, a new Yale study finds. In an experiment, the researchers found that exposure to the molecule in mice caused white blood cells to mobilize from the bone marrow, a response that could inform future treatment for patients who need a boost in immune activity, the researchers say. The findings were reported Jan. 31 in the journal Immunity ..read more

Using CRISPR/Cas9, scientists identified RBM5 as a vital component of leukemia cell fitness, making it a promising target for drug development ..read more

Researchers have identified a novel pharmaceutical compound that successfully kills leukemia and lymphoma cancer cells, potentially paving the way for new forms of therapy ..read more

Decisions on treatment for leukemia patients are based, among other things, on a series of certain genetic features of the disease. IT specialists and physicians have now shown how a method based on artificial intelligence can be used to predict various genetic features on the basis of high-resolution microscopic images of bone marrow smears ..read more