CellPress | Neuron Journal
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Neuron publishes ground-breaking research papers, reviews & commentary across neuroscience and is a premier intellectual forum for the neuroscience community.
CellPress | Neuron Journal
1w ago
In an interview with Neuron, Joseph LeDoux outlines his early work on consciousness in split-brain patients, his transition into studying emotional behavior in rodents, and his continued exploration of consciousness in books and other writings. He describes how his research fused with his interest in music, which he pursued though his band, The Amygdaloids, and their unique genre, “heavy mental ..read more
CellPress | Neuron Journal
1w ago
In this issue of Neuron, Znamenskiy et al.1 unveil functional connection specificity between PV+ inhibitory interneurons and excitatory pyramidal neurons in mouse visual cortex, providing a circuit mechanism for stable amplification of cortical subpopulations ..read more
CellPress | Neuron Journal
1w ago
The brain-gut neurocircuitry is proving to be finely involved in a wide range of physiological functions. In this issue of Neuron, Ren et al. show that adrenergic signaling suppresses postprandial glucagon-like peptide 1 (GLP-1) secretion. This, in turn, raises circulating glucose levels and impairs brain glucose uptake and cognitive function ..read more
CellPress | Neuron Journal
1w ago
The review by Wolff and Halassa discusses the role of the mediodorsal (MD) thalamus in executive control. By integrating anatomical, physiological, functional, and computational studies, the authors provide a novel framework on MD function that is of basic and translational relevance ..read more
CellPress | Neuron Journal
1w ago
Mocellin et al. investigate the functional role of the MSDBglu inputs to the VTA. Combining in vivo circuit manipulation and in vitro electrophysiology, they show that the MSDBglu-VTA pathway bidirectionally controls locomotion, increases environmental exploratory actions, and relies on septal inputs to VTADA, VTAglu, and VTADA/glu neurons ..read more
CellPress | Neuron Journal
1w ago
Yang et al. applied an in vitro optogenetics-based proteomic screening platform to identify that the phosphorylation of pyruvate dehydrogenase (pPDH) inversely correlates with neuronal activity both in vitro and in vivo. pPDH can serve as a trackable endogenous inverse activity marker (IAM) for post hoc identification of inhibited neurons ..read more
CellPress | Neuron Journal
1w ago
Neuronal ensembles, defined as groups of neurons displaying recurring patterns of coordinated activity, represent an intermediate functional level between individual neurons and brain areas. Novel methods to measure and optically manipulate the activity of neuronal populations have provided evidence of ensembles in the neocortex and hippocampus. Ensembles can be activated intrinsically or in response to sensory stimuli and play a causal role in perception and behavior. Here we review ensemble phenomenology, developmental origin, biophysical and synaptic mechanisms, and potential functional rol ..read more
CellPress | Neuron Journal
1w ago
Znamenskiy et al. reveal unexpected precision of synaptic strength of parvalbumin-positive inhibitory neurons in the mouse visual cortex. By measuring their visual responses and synaptic connectivity, they show that PV+ cells preferentially inhibit those pyramidal cells that provide them with strong excitation and have similar patterns of responses in vivo ..read more
CellPress | Neuron Journal
1w ago
Ren et al. characterize a neuro-enteroendocrine cell unit operating at the brain-gut neuronal axis, which restrains GLP-1 release upon glucose ingestion and compromises brain function by reducing glucose utilization in the brain ..read more
CellPress | Neuron Journal
1w ago
Vu et al. present a customizable approach using small-diameter optical fibers that enables dense measurements and targeted manipulations of distributed neural activity over large 3D volumes at a spatial resolution and coverage previously inaccessible. They reveal modality-specific spatiotemporal patterns of striatum-wide dopamine release in response to sensory stimuli and precise mapping of a specific behavior onto striatal location ..read more