PMID:  Toxicon. 2024 Apr ;241:107664. Epub 2024 Mar 8. PMID: 38460603 Abstract Title:  Astaxanthin treatment reduces kidney damage and facilitates antioxidant recovery in lithium-intoxicated rats. Abstract:  OBJECTIVE: This study aimed to evaluate the protective effects of astaxanthin against lithium-induced nephrotoxicity, focusing on histopathological changes, oxidative stress modulation, and alteration in the expression of key proteins related to apoptosis and inflammation.METHODS: In this study, 56 male rats were utilized and divided into experimental groups subjected to lit ..read more

PMID:  Int J Nanomedicine. 2024 ;19:2395-2407. Epub 2024 Mar 7. PMID: 38469059 Abstract Title:  Pioneering Astaxanthin-Tumor Cell Membrane Nanoparticles for Innovative Targeted Drug Delivery on Melanoma. Abstract:  BACKGROUND: Recently, the use of the tumor or its secretions as drug carriers has gradually become popular, with the advantages of high biocompatibility and enhanced drug delivery to specific cells. Melanoma is the most malignant tumor of all skin cancers; it is the most metastatic and, therefore, the most difficult to treat. The main purpose of this study is to devel ..read more

PMID:  Food Funct. 2024 Apr 22 ;15(8):4207-4222. Epub 2024 Apr 22. PMID: 38512055 Abstract Title:  Astaxanthin targets IL-6 and alleviates the LPS-induced adverse inflammatory response of macrophages. Abstract:  Numerous natural compounds are recognized for their anti-inflammatory properties attributed to antioxidant effects and the modulation of key inflammatory factors. Among them, astaxanthin (AST), a potent carotenoid antioxidant, remains relatively underexplored regarding its anti-inflammatory mechanisms and specific molecular targets. In this study, human monocytic leukemi ..read more

n/a PMID:  Cureus. 2024 Feb ;16(2):e54667. Epub 2024 Feb 22. PMID: 38524025 Abstract Title:  Efficacy and Safety of Astaxanthin in the Management of Oral Submucous Fibrosis: A Preliminary Randomized Controlled Trial. Abstract:  BACKGROUND: Oral submucous fibrosis (OSMF) is a chronic, potentially malignant disorder characterized by progressive fibrosis of the oral mucosa, leading to restricted mouth opening and discomfort. This study investigates the efficacy and safety of astaxanthin, a potent antioxidant and anti-inflammatory carotenoid, in the comprehensive management of OSMF ..read more

PMID:  Int Immunopharmacol. 2024 Mar 26 ;132:111928. Epub 2024 Mar 26. PMID: 38537540 Abstract Title:  Protective effect of astaxanthin on ANCA-associated vasculitis. Abstract:  OBJECTIVE: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic autoimmune disease characterized by inflammation and fibrinoid necrosis of medium and small vessels, and its pathogenesis is closely related to inflammation and oxidative stress. Astaxanthin (ATX) is a carotenoid with anti-inflammatory, antioxidant, and immunomodulatory effects. We hypothesized that ATX could ..read more

PMID:  Nutrients. 2024 Mar 14 ;16(6). Epub 2024 Mar 14. PMID: 38542737 Abstract Title:  The Effects of Astaxanthin on Cognitive Function and Neurodegeneration in Humans: A Critical Review. Abstract:  Oxidative stress is a key contributing factor in neurodegeneration, cognitive ageing, cognitive decline, and diminished cognitive longevity. Issues stemming from oxidative stress both in relation to cognition and other areas, such as inflammation, skin health, eye health, and general recovery, have been shown to benefit greatly from antioxidant use. Astaxanthin is a potent antioxida ..read more

PMID:  Molecules. 2024 Mar 14 ;29(6). Epub 2024 Mar 14. PMID: 38542929 Abstract Title:  Oral Delivery of Astaxanthin via Carboxymethyl Chitosan-Modified Nanoparticles for Ulcerative Colitis Treatment. Abstract:  The oral delivery strategy of natural anti-oxidant and anti-inflammatory agents has attracted great attention to improve the effectiveness of ulcerative colitis (UC) treatment. Herein, we developed a novel orally deliverable nanoparticle, carboxymethyl chitosan (CMC)-modified astaxanthin (AXT)-loaded nanoparticles (CMC-AXT-NPs), for UC treatment. The CMC-AXT-NPs were eva ..read more

PMID:  Respir Res. 2024 Mar 30 ;25(1):148. Epub 2024 Mar 30. PMID: 38555458 Abstract Title:  Astaxanthin attenuates cigarette smoke-induced small airway remodeling via the AKT1 signaling pathway. Abstract:  BACKGROUND: Astaxanthin (AXT) is a keto-carotenoid with a variety of biological functions, including antioxidant and antifibrotic effects. Small airway remodeling is the main pathology of chronic obstructive pulmonary disease (COPD) and is caused by epithelial-to-mesenchymal transition (EMT) and fibroblast differentiation and proliferation. Effective therapies are still lacki ..read more

PMID:  Knee. 2024 Mar 29 ;48:83-93. Epub 2024 Mar 29. PMID: 38555717 Abstract Title:  Astaxanthin reduces inflammation and promotes a chondrogenic phenotype by upregulating SIRT1 in osteoarthritis. Abstract:  OBJECTIVE: To investigate the effects of astaxanthin (AST) on mouse osteoarthritis (OA) and lipopolysaccharide (LPS)-induced ATDC5 cell damage and to explore whether SIRT1 protein plays a role.METHODS: In this study, some mouse OA models were constructed by anterior cruciate ligament transection (ACLT). Imaging, molecular biology and histopathology methods were used to stud ..read more

PMID:  Nutr Cancer. 2024 Apr 3:1-14. Epub 2024 Apr 3. PMID: 38567899 Abstract Title:  Astaxanthin Ameliorates Skeletal Muscle Atrophy in Mice With Cancer Cachexia. Abstract:  Astaxanthin (AST) is a natural marine carotenoid with a variety of biological activities. This study aimed to demonstrate the possible mechanisms by which AST improves skeletal muscle atrophy in cancer cachexia. In this study, the effects of different doses of AST (30 mg/kg b.w., 60 mg/kg b.w. and 120 mg/kg b.w.) on skeletal muscle functions were explored in mice with cancer cachexia. The results showed tha ..read more