PMID:  Discov Med. 2024 Jan ;36(180):199-208. PMID: 38273760 Abstract Title:  Curcumol Enhances the Antitumor Effect of Lenvatinib on Hepatocellular Carcinoma Cells. Abstract:  BACKGROUND: Lenvatinib is an important molecular target drug for the treatment of advanced hepatocellular carcinoma (HCC). However, the application of molecular targeted therapies for HCC also faces some challenges. Cumulative evidence has also shown that curcumol is a potential anti-HCC drug. Curcumol can be used as a chemosensitizer to enhance the antitumor effect of chemotherapeutic drugs. The purpose ..read more

PMID:  Exp Ther Med. 2024 May ;27(5):232. Epub 2024 Mar 26. PMID: 38628654 Abstract Title:  Icariin‑curcumol promotes ferroptosis in prostate cancer cells through Nrf2/HO‑1 signaling. Abstract:  Ferroptosis is a form of regulatory cell death that relies on iron and reactive oxygen species (ROS) to inhibit tumors. The present study aimed to investigate whether icariin-curcumol could be a novel ferroptosis inducer in tumor inhibition. Various concentrations of icariin-curcumol were used to stimulate prostate cell lines (RWPE-2, PC-3, VCAP and DU145). Small interfering negative con ..read more

PMID:  Clin Exp Pharmacol Physiol. 2024 Jun ;51(6):e13867. PMID: 38684457 Abstract Title:  Curcumol reduces lower limb arteriosclerosis in rats by inhibiting human arterial smooth muscle cell activity. Abstract:  Cardiovascular diseases, particularly those involving arterial stenosis and smooth muscle cell proliferation, pose significant health risks. This study aimed to investigate the therapeutic potential of curcumol in inhibiting platelet-derived growth factor-BB (PDGF-BB)-induced human aortic smooth muscle cell (HASMC) proliferation, migration and autophagy. Using cell viab ..read more

This article is copyrighted by GreenMedInfo LLC, 2024 Visit our Re-post guidelines For decades, we've been bombarded with the message that cow's milk is a wholesome, healthy food essential for strong bones and a fit body. But what if this pervasive belief is not only misguided but actually dangerous? A growing body of research suggests that conventional cow's milk, far from being a health elixir, may be a toxic substance linked to a disturbing array of illnesses and disorders. The A1 Milk Problem read more ..read more

This article is copyrighted by GreenMedInfo LLC, 2024 Visit our Re-post guidelines In a world where depression affects millions, a groundbreaking study has revealed a simple yet powerful solution that may be as close as your running shoes. Prepare to lace up and discover how exercise is proving to be a formidable contender in the fight against this debilitating mental health condition. The Power of Movement: Exercise as a Depression-Buster read more ..read more

PMID:  Heliyon. 2024 Jan 30 ;10(2):e24840. Epub 2024 Jan 17. PMID: 38304804 Abstract Title:  Thymoquinone alleviates cisplatin-induced kidney damage by reducing apoptosis in a rat model. Abstract:  PURPOSE: The aim of the study was to compare the ameliorating effects of thymoquinone at various dosages on cisplatin-induced renal toxicity, and to investigate its effects on cisplatin-induced nephrocyte apoptosis via the mitochondrial pathway in a rat model.METHODS: A rat model of cisplatin-induced renal damage was established, with thymoquinone treatment groups (receiving 1, 3, 5 ..read more

PMID:  Chem Biodivers. 2024 Feb ;21(2):e202301886. Epub 2024 Feb 2. PMID: 38308180 Abstract Title:  A Study on Thymoquinone: Antioxidant Capacity and Anticancer Activities in LoVo Colorectal Cancer Cells. Abstract:  Thymoquinone has antioxidant and anticancer effects. This study investigates the cytotoxic, genotoxic, and apoptotic effects of black seed and its active ingredient, thymoquinone on colorectal cancer cells. The antioxidant content of Black seed methanolic extracts (BSME) with different concentrations (50, 500 and 1000 μg/mL) were determined by the photometric methods ..read more

PMID:  Neurotoxicology. 2024 Mar ;101:54-67. Epub 2024 Feb 5. PMID: 38325603 Abstract Title:  Thymoquinone regulates microglial M1/M2 polarization after cerebral ischemia-reperfusion injury via the TLR4 signaling pathway. Abstract:  Acute ischemic stroke followed by microglia activation, and the regulation of neuroinflammatory responses after ischemic injury involves microglia polarization. microglia polarization is involved in the regulation of neuroinflammatory responses and ischemic stroke-related brain damage. Thymoquinone (TQ) is an anti-inflammatory agent following ischemi ..read more

PMID:  Front Microbiol. 2024 ;15:1353875. Epub 2024 Feb 13. PMID: 38414774 Abstract Title:  Molecular insight into thymoquinone mechanism of action against. Abstract:  Natural products are promising antimicrobials, usually having multiple and different cellular targets than synthetic antibiotics. Their influence on bacteria at various metabolic and functional levels contributes to higher efficacy even against drug-resistant strains. One such compound is a naturally occurring p-benzoquinone - thymoquinone. It is effective against different bacteria, including multidrug-resistant ..read more

PMID:  Drug Dev Res. 2024 Apr ;85(2):e22171. PMID: 38459752 Abstract Title:  Protective effect of thymoquinone nanoemulsion in reducing the cardiotoxic effect of 5-fluorouracil in rats. Abstract:  5-Fluorouracil (5-FU), which is one of the most widely used chemotherapy drugs, has various side effects on the heart. Thymoquinone (TMQ), the main bioactive component of Nigella sativa, has antioxidant and protective effects against toxicity. In this study, we investigated the protective effect of thymoquinone against cardiotoxicity caused by 5-FU in vitro and in vivo models. H9C2 cel ..read more