Int Immunopharmacol. 2024 May 2;134:112185. doi: 10.1016/j.intimp.2024.112185. Online ahead of print. ABSTRACT Chronic ethanol consumption is a prevalent condition in contemporary society and exacerbates anxiety symptoms in healthy individuals. The activation of microglia, leading to neuroinflammatory responses, may serve as a significant precipitating factor; however, the precise molecular mechanisms underlying this phenomenon remain elusive. In this study, we initially confirmed that chronic ethanol exposure (CEE) induces anxiety-like behaviors in mice through open field test and elevated p ..read more

Brief Bioinform. 2024 Mar 27;25(3):bbae207. doi: 10.1093/bib/bbae207. ABSTRACT Cancer stem cells (CSCs) are a subpopulation of cancer cells within tumors that exhibit stem-like properties and represent a potentially effective therapeutic target toward long-term remission by means of differentiation induction. By leveraging an artificial intelligence approach solely based on transcriptomics data, this study scored a large library of small molecules based on their predicted ability to induce differentiation in stem-like cells. In particular, a deep neural network model was trained using publicl ..read more

J Alzheimers Dis. 2024;99(1):363-375. doi: 10.3233/JAD-240037. ABSTRACT BACKGROUND: A timely diagnosis of dementia can be beneficial for providing good support, treatment, and care, but the diagnostic rate remains unknown and is probably low. OBJECTIVE: To determine the dementia diagnostic rate and to describe factors associated with diagnosed dementia. METHODS: This registry linkage study linked information on research-based study diagnoses of all-cause dementia and subtypes of dementias, Alzheimer’s disease, and related dementias, in 1,525 participants from a cross-sectional population-base ..read more

J Gerontol Soc Work. 2024 May 3:1-19. doi: 10.1080/01634372.2024.2349603. Online ahead of print. ABSTRACT A randomized controlled trial was conducted to examine the effects of bright light therapy on agitation in older adults with dementia in Macao. This study involved 31 participants: 10 in the outdoor light treatment group, 11 in the indoor light-box treatment group, and 10 in the control group. Significant reductions in agitation were observed in the two treatment groups over four weeks compared to the control group. However, no statistical difference in in cognitive function between exper ..read more

Biosens Bioelectron. 2024 Apr 16;258:116298. doi: 10.1016/j.bios.2024.116298. Online ahead of print. ABSTRACT Wireless activation of the enteric nervous system (ENS) in freely moving animals with implantable optogenetic devices offers a unique and exciting opportunity to selectively control gastrointestinal (GI) transit in vivo, including the gut-brain axis. Programmed delivery of light to targeted locations in the GI-tract, however, poses many challenges not encountered within the central nervous system (CNS). We report here the development of a fully implantable, battery-free wireless devic ..read more

J Neurosurg. 2024 May 3:1-8. doi: 10.3171/2024.2.JNS232918. Online ahead of print. ABSTRACT OBJECTIVE: This study was conducted to investigate the impact of antiplatelet administration in the periprocedural period on the occurrence of thromboembolic complications (TECs) in patients undergoing treatment using the Woven EndoBridge (WEB) device for intracranial wide-necked bifurcation aneurysms. The primary objective was to assess whether the use of antiplatelets in the pre- and postprocedural phases reduces the likelihood of developing TECs, considering various covariates. METHODS: A retrospect ..read more

PLoS One. 2024 May 3;19(5):e0302155. doi: 10.1371/journal.pone.0302155. eCollection 2024. ABSTRACT BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is strongly associated with type 2 diabetes mellitus (T2DM). Lifestyle intervention remains a preferred treatment modality for NAFLD. The glucagon-like peptide (GLP-1) receptor agonists and sodium-glucose cotransporter-2 (SGLT-2) inhibitors have been developed as new glucose-lowering drugs, which can improve fatty liver via an insulin-independent glucose-lowering effect. However, studies exploring the efficacy of GLP-1 receptor agonists combin ..read more

JMIR Form Res. 2024 May 3;8:e51694. doi: 10.2196/51694. ABSTRACT BACKGROUND: Face-to-face hearing voices peer support groups (HVGs), a survivor-led initiative that enables individuals who hear voices to engage with the support of peers, have a long-standing history in community settings. HVGs are premised on the notion that forming authentic, mutual relationships enables the exploration of one’s voice hearing experiences and, in turn, reduces subjective distress. As such, group cohesion is assumed to be a central mechanism of change in HVGs. The rise of digital mental health support, coupled ..read more

Sci Adv. 2024 May 3;10(18):eadl6082. doi: 10.1126/sciadv.adl6082. Epub 2024 May 3. ABSTRACT The AAA+-ATPase valosin-containing protein (VCP; also called p97 or Cdc48), a major protein unfolding machinery with a variety of essential functions, localizes to different subcellular compartments where it has different functions. However, the processes regulating the distribution of VCP between the cytosol and nucleus are not understood. Here, we identified p37 (also called UBXN2B) as a major factor regulating VCP nucleocytoplasmic shuttling. p37-dependent VCP localization was crucial for local cyto ..read more

Work. 2024 May 3. doi: 10.3233/WOR-230257. Online ahead of print. ABSTRACT BACKGROUND: Psychiatric disorders are the conditions that most contribute to incapacity worldwide. While many healthcare professionals adapt in dealing with various demands, others do not. How much of these conditions is associated with affective experience needs to be studied. OBJECTIVE: Assess the prevalence of anxiety, depression, and stress while investigating the relationship between the presence of positive and negative affect in healthcare professionals. METHODS: This study’s convenience sample consisted of 975 ..read more