Older Siblings Made Possible Just-Approved Gene Therapy for Metachromatic Leukodystrophy
PLOS Blogs | DNA Science Blog
by Ricki Lewis, PhD
6d ago
The Food and Drug Administration just announced approval of Lenmeldy (atidarsagene autotemcel), a gene therapy to treat the neurological condition metachromatic leukodystrophy (MLD). Available in Italy for three years, Lenmeldy (atidarsagene autotemcel), from Orchard Therapeutics, is groundbreaking, but comes at quite a cost – the $4.25 million price tag for the one-time infusion, and for the older siblings who contributed to developing the gene treatment, but were too sick to receive it. An Ultrarare Neurological Condition MLD affects the white matter in the brain, causing progressive loss ..read more
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Cultivated Meat? Let Them Eat Snake
PLOS Blogs | DNA Science Blog
by Ricki Lewis, PhD
1w ago
Biotechnology has solved many problems, from recombinant DNA and monoclonal antibody-derived drugs, to gene therapy and stem cell transplants, to RNA-based vaccines and genetically modified plants that resist diseases and pesticides. In contrast, so-called cultivated meat has been, so far, a failure. Joe Fassler’s in-depth Opinion piece in the February 9 New York Times, The Revolution That Died on Its Way to Dinner, digests the unrealistic expectations, shortcuts, and glitches that have stymied what he envisions as “a high-tech factory housing steel tanks as tall as apartment buildings and c ..read more
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How the Human Lost Its Tail
PLOS Blogs | DNA Science Blog
by Ricki Lewis, PhD
2w ago
In 1902’s Just So Stories for Little Children, British author Rudyard Kipling famously explained curiosities of the animal kingdom: How the Leopard Got His Spots, How the Camel got his Hump, How the Rhinoceros got his Skin, to name a few. Reading Just So Stories was one of my earliest memories of thinking like a scientist. I see them in articles on animals’ oddities, such as How the Tabby Got its Stripes, in which I explored a molecular explanation for fur color patterns set in the fetus, from a report in Nature Communications. Now new research published in Nature brings the just-so approach ..read more
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17 Timepoints When a Human Life Begins: 2024 Version in the Wake of the Alabama Ruling
PLOS Blogs | DNA Science Blog
by Ricki Lewis, PhD
1M ago
I wish that I could stop reposting this essay – I do so whenever limitations on women’s reproductive rights become ever more egregious. And that certainly happened when the Supreme Court of Alabama ruled on February 16 that human embryos, even those in the suspended development of a deep freeze, are “children” under the state’s Wrongful Death of a Minor Act. I wrote this essay in 2013, in response to common confusion of “embryo” and “fetus” – never imagining the blurring would extend to “baby”. We scientists are sticklers for precision and accuracy. Even physicians oversimplify human prenatal ..read more
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“Ordinary Soil” Revisits the Weedkiller and AgBiotech Story, While Feeding the Scientist-As-Nerd Stereotype
PLOS Blogs | DNA Science Blog
by Ricki Lewis, PhD
1M ago
I love the spectacular symbiosis of my vegetable garden as harvest time approaches. Beanstalks spiral up cornstalks, their tendrils teasing nearby tomato stems. Below, broad leaves protect ballooning squashes from the slugs that appear, seemingly from nowhere, after a rain, while providing water for passing furry creatures. The synergism of a garden is an ancient and somewhat obvious idea. Many indigenous peoples honored the “three sisters” of corn, beans, and squash. My kids – three sisters – learned about the practice in grade school, and all recall the first meal that we grew: corn, beans ..read more
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Designing a Better Probiotic. CRISPR Hubris?
PLOS Blogs | DNA Science Blog
by Ricki Lewis, PhD
1M ago
Every morning I pop a Pearl probiotic. I try hard not to drop it, for the tiny, slippery yellow sphere bounces, is impossible to pick up, and cats love to bat them into unreachable domains. A probiotic is, technically speaking, a population of live microorganisms that confers health benefits on the multicellular organism that they inhabit – such as a human. Probiotics alter the bacterial, viral, and fungal milieu within and on us – our microbiomes – in ways that ease digestion, counter inflammation, strengthen the gut lining, affect brain function, and even squelch tumors. Each Pearl – or othe ..read more
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Transmissible Alzheimer’s Disease? Long-Ago Growth Hormone Treatment and a Legacy of Cannibalism and Mad Cows
PLOS Blogs | DNA Science Blog
by Ricki Lewis, PhD
2M ago
Five people treated for pituitary dwarfism decades ago with human growth hormone (hGH) pooled from cadavers have shown cognitive decline reminiscent of early-onset Alzheimer’s disease. Their dementia likely arose from transmission of the bits of amyloid-beta protein that lie behind Alzheimer’s delivered along with the needed hormone, initiating a molecular chain reaction that led to brain effects decades later. Recombinant DNA technology has since provided a pure source of the hormone. The cognition decline in these people is iatrogenic – caused by a medical procedure. The pooled hGH included ..read more
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Chewing Gum Reveals Stone Age Diet and Disease
PLOS Blogs | DNA Science Blog
by Ricki Lewis, PhD
2M ago
We can learn about life, past and present, anywhere we find DNA and determine its sequence. DNA Science has described intriguing sources of environmental DNA, aka eDNA: DNA in Strange Places: Hippo Poop, Zoo Air, and Cave Dirt and A Glimpse of the Ocean’s Twilight Zone Through Environmental DNA.   Human remains also harbor bits of DNA that can reveal how people lived long ago. A recent report in PLOS ONE analyzes DNA from an adenovirus and a herpes virus discovered in preserved feces – coprolites – from 5,500 to 7,000 years ago at an archaeological site in Japan. The findings suggest that ..read more
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Multi-cancer Early Detection Blood Tests (MCED) Debut
PLOS Blogs | DNA Science Blog
by Ricki Lewis, PhD
2M ago
A 52-year-old woman is at her annual physical exam. The physician assistant mentions he’ll need two extra vials of blood for new cancer screening tests, one just FDA-approved, the other available as part of a clinical trial. “But I already get mammograms and colonoscopies based on family history, and my husband gets his PSA screen for prostate cancer every year. So far, so good. Why do I need these new tests?” the patient asks. “They can catch cancers much earlier, from DNA and proteins in your blood plasma, the liquid part. Including cancers much rarer than breast, colon, and prostate.” “Sure ..read more
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The 500th Blog Post at DNA Science: In Celebration of Vaccines
PLOS Blogs | DNA Science Blog
by Ricki Lewis, PhD
3M ago
A few weeks ago, I noticed a surprising metric when posting my weekly DNA Science blog – at year’s end, I’d hit #500! That got me thinking. Looking back, which blog post was the most important? The answer came to me quickly – but it’s not what I would have expected when I began more than a decade ago. The Birth of DNA Science When St. Martin’s Press was about to publish my book about gene therapy in 2012, my agent urged me to start blogging. I needed to widen my audience beyond college students forced to buy my textbooks and readers of the articles I’d been cranking out since the 1980s. The bo ..read more
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