Efficient bioprocess development is a vital objective for all biopharmaceutical developers, particularly as product demand rises. Whether the product is a recombinant protein or a vaccine, effectively achieving this goal is essential to accelerate the product to market and enable economically sustainable large-scale manufacturing in the long term. Decisions regarding the bioprocess cell line, media, scale-up, and regulatory approval can have direct effects on overall product speed-to-market and costs. Furthermore, relatively minor mistakes during these stages can slow down regulatory approval ..read more

In the world of cell culture, creating the perfect environment for cells to thrive is of paramount importance. It’s a delicate dance, a balance of temperature, gas tension, and humidity that can mean the difference between successful cell growth and a failed experiment. But how do you ensure that these conditions are always optimal? The answer lies in the technology behind our Thermo Scientific CO2 incubators. In our smart note, Which incubation parameters are most important for proper cell growth and expression?, we delve into the intricacies of CO2 incubators and their role in promoting ..read more

In the world of biology research, particularly in cell culture incubation, precision and control are critical. Providing a controlled, healthy environment for cell growth in a CO2 incubator requires uniform conditions throughout the incubator and rapid recovery of temperature, atmospheric gases, and humidity after each door opening. The Thermo Scientific™ Heracell™ VIOS™ CO2 Incubator with active airflow technology was designed to meet these challenges. A key feature of this design is the unique active airflow system, which helps ensure a homogenous environment so that cells spend maximum ..read more

by Halina Zakowicz, PhD A guide and decision tree to help you choose between protein purification methods   Table of Contents Introduction to protein purification methods What is protein sample desalting? Pros of protein desalting Cons of protein desalting What is protein sample dialysis? Pros of protein dialysis Cons of protein dialysis When to use desalting for protein analysis When to use dialysis for protein analysis More tools and resources about protein purification methods Protein sample desalting and protein sample dialysis are two common protein purification methods used for sam ..read more

In celebration of Earth Day and Earth Month, we’ve rounded up five sustainability discoveries made possible by advancements in synthetic biology.   By Kendra Atleework From the production of rocket biofuel to bioremediation of pollutants, innovations in the field of synthetic biology may seem straight out of science fiction. Synthetic biology is a cross-disciplinary field focused on reengineering organisms to exhibit new qualities and serve specific purposes. This includes everything from engineering proteins to be able to convert problematic substrates, to synthesizing entire artificial ..read more

In the rapidly evolving field of cell therapy production, ensuring the safety and quality of the final product is of paramount importance. One crucial step in this process is rapid sterility testing, which plays a vital role in detecting contamination. By swiftly detecting contamination early in the production process, manufacturers can safeguard the integrity and efficacy of their products. Read on to explore the importance of rapid sterility testing and how it benefits cell therapy manufacturers worldwide. Introduction The cornerstone of any therapeutic manufacturing process is the assuranc ..read more

One of the last northern white rhinos at a Kenyan reserve   This story is part of our celebration of innovation in 2024.   by Dana D’Amico, Connect to Science Dr. Jeanne Loring and the San Diego Zoo hope to revive the northern white rhinoceros and create a blueprint for stem cell-based conservation   Marisa Korody arrived at the lab one day in 2021 to find Angalifu’s heart cells beating for the first time since he’d died seven years before. Pumping to the rhythm of their own electricity, here were the heart muscle cells of the second-to-last male northern white rhino to walk ..read more

Enhance your bioprocessing knowledge With the evolution of biopharmaceutical production processes comes the need for innovative technologies to address challenges and deliver efficiencies in your bioprocess workflow. How do you keep up with the latest technologies? Learn more about the Pharmaceutical Analytics Learning Lab—the latest educational hub from Thermo Fisher Scientific. Stay up-to-date on the latest bioprocessing solutions When sensitivity, accuracy, and time-to-results are critical, leveraging the right analytical and QC testing solution offers reliability that translates to time ..read more

Every material used at every stage of a cell therapy workflow can impact the efficacy of the final deliverable drug. Gibco CTS OpTmizer One Serum Free Medium (SFM) takes this into account. Not only is this thoughtfully designed nutrition for T-cells, but it is an animal origin-free (AOF) formulation. Why is that important? The risk of contamination with an adventitious agent is a serious concern when starting with a small sample of cells and a waiting patient. An animal origin-free formulation helps mitigate this risk. Of course, there are other critical factors that a cell culture medium dir ..read more

by Halina Zakowicz, PhD A guide and decision tree to help you choose a protein purification process   Table of Contents Introduction What is protein sample desalting? Pros of protein desalting Cons of protein desalting What is protein sample dialysis? Pros of protein dialysis Cons of protein dialysis When to use desalting for protein analysis When to use dialysis for protein analysis More tools and resources Protein sample desalting and protein sample dialysis are two common techniques used in protein purification and sample preparation. While they both aim to remove small molecules or u ..read more