Vascular response patterns to targeted therapies in murine breast cancer models with divergent degrees of malignancy
Breast Cancer Research
by
2d ago
Response assessment of targeted cancer therapies is becoming increasingly challenging, as it is not adequately assessable with conventional morphological and volumetric analyses of tumor lesions. The tumor mic ..read more
Visit website
Integration of multiomics data shows down regulation of mismatch repair and tubulin pathways in triple-negative chemotherapy-resistant breast tumors
Breast Cancer Research
by
2d ago
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype. Patients with TNBC are primarily treated with neoadjuvant chemotherapy (NAC). The response to NAC is prognostic, with reductio ..read more
Visit website
Molecular profiling of a real-world breast cancer cohort with genetically inferred ancestries reveals actionable tumor biology differences between European ancestry and African ancestry patient populations
Breast Cancer Research
by
2d ago
Endocrine-resistant HR+/HER2- breast cancer (BC) and triple-negative BC (TNBC) are of interest for molecularly informed treatment due to their aggressive natures and limited treatment profiles. Patients of Afr ..read more
Visit website
Breast metastatic tumors in lung can be substituted by lung-derived malignant cells transformed by alternative splicing H19 lncRNA
Breast Cancer Research
by
2d ago
Metastasis accounts for most cancer-associated deaths; yet, this complex process remains poorly understood, particularly the relationship between distant metastasis and primary site-derived cells. Here, we mod ..read more
Visit website
Progesterone from ovulatory menstrual cycles is an important cause of breast cancer
Breast Cancer Research
by
2d ago
Many factors, including reproductive hormones, have been linked to a woman’s risk of developing breast cancer (BC). We reviewed the literature regarding the relationship between ovulatory menstrual cycles (MCs ..read more
Visit website
S100A6 inhibits MDM2 to suppress breast cancer growth and enhance sensitivity to chemotherapy
Breast Cancer Research
by
1w ago
S100A6 and murine double minute 2 (MDM2) are important cancer-related molecules. A previous study identified an interaction between S100A6 and MDM2 by size exclusion chromatography and surface plasmon resonanc ..read more
Visit website
Risk of second primary cancer among women in the Kaiser Permanente Breast Cancer Survivors Cohort
Breast Cancer Research
by
3w ago
Breast cancer survivors are living longer due to early detection and advances in treatment and are at increased risk for second primary cancers. Comprehensive evaluation of second cancer risk among patients tr ..read more
Visit website
Systematic screening identifies ABCG2 as critical factor underlying synergy of kinase inhibitors with transcriptional CDK inhibitors
Breast Cancer Research
by
3w ago
Triple-negative breast cancer (TNBC) is a subtype of breast cancer with limited treatment options and poor clinical prognosis. Inhibitors of transcriptional CDKs are currently under thorough investigation for ..read more
Visit website
Vangl-dependent Wnt/planar cell polarity signaling mediates collective breast carcinoma motility and distant metastasis
Breast Cancer Research
by
3w ago
In light of the growing appreciation for the role of collective cell motility in metastasis, a deeper understanding of the underlying signaling pathways will be critical to translating these observations to th ..read more
Visit website
Breast cancer genomes from CHEK2 c.1100delC mutation carriers lack somatic TP53 mutations and display a unique structural variant size distribution profile
Breast Cancer Research
by
3w ago
c.1100delC was the first moderate-risk breast cancer (BC) susceptibility allele discovered. Despite several genomic, transcriptomic and functional studies, however, it is still unclear how exactly ..read more
Visit website

Follow Breast Cancer Research on Feedspot

Continue with Google
Continue with Apple
OR