Senescent cells accumulate with age as the immune system falters in its ability to clear these cells in a timely fashion. Senolytic therapies selectively destroy some fraction of senescent cells, and first generation senolytic drugs have been demonstrated to rapidly and impressively reverse age-related disease and extend life in mice. The best of these first generation drugs are repurposed cancer therapeutics such as dasatinib and navitoclax, with the jury still out on whether plant extracts like fisetin can be competitive on their own rather than in combination with the chemotherapeutics. The ..read more

Repair Biotechnologies was invited to present at this year's Rejuvenation Startup Summit in Berlin, and so my CSO Mourad Topors and I attended. There were more people present this year than were at the already busy 2022 event. This is perhaps an indication of a still growing interest in the longevity industry as it expands, particularly given the present poor market for investment in biotechnology companies. Investors are tending to stay home this year, but nonetheless there was a fair sized crowd in attendance. Michael Greve's Forever Healthy Foundation hosts the Rejuvenation Startup Summit ..read more

This article serves as a high level overview of the present state of bioprinting of three-dimensional sect (Source: Fight Aging ..read more

One of the consequences of the COVID-19 pandemic is that the biotech industry is now geared up for the use of messenger RNA (mRNA) as a basis for therapy. The broadest use at present is vaccination, as doses can be very low and the experience gained during the pandemic is directly applicable, but many other forms of mRNA gene therapy are under development. Given the ability to produce novel mRNA vaccines, the most obvious use beyond infectious disease is to force the immune system to engage with cancerous tissue. This line of development appears to be making good progress. In a first-ever huma ..read more

This study was the first to examine how these networks interact with physical activity and fitness to impact how the brain functions. "This paper is exciting because it gives us some evidence that when people whose brain networks aren't functioning optimally engage in physical activity, we see improvement in their executive function and their independence. Maybe just take the stairs on the way to work. Stand up and walk around a little bit more. That's where you get the most bang for your buck, not crazy, high-intensity exercise." Variations in Biological Age Across Organs in Younger Individua ..read more

By DAVID WARMFLASH, MD This is part 2 of David Warmlash’s takedown of Robert W. Malone’s appearance (transcript) on the Rogan podcast. Part 1 is here Menstruation and Fertility Much more than the line about reproductive damage in the Wisconsin News clip that we used to open the story, Malone used the Rogan interview to dive more deeply into the topic, starting with:  …there’s a huge number of dysmenorrhea and menometrorrhagia… By that, he meant excessive menstrual cramping and very heavy, often irregular, bleeding, which he followed up with: …they DENY it… Judging by other parts of the in ..read more

Mitochondria are the power plants of the cell. They are deeply integrated into many core cellular processes, but their primary responsibility is to generate adenosine triphosphate (ATP), an energy store molecule used to power cellular activities. Mitochondria are the evolved descendants of ancient symbiotic bacteria, and carry a small remnant genome encoding a handful of genes vital to ATP production. Each cell contains hundreds of mitochondria. Worn mitochondria are destroyed by the quality control process of mitophagy, while other mitochondria replicate much like bacteria to make up numbers ..read more

In this study, we report that microglia in the adult mouse hippocampus, a brain region responsible for learning and memory and susceptible to age-related cognitive decline, advance through intermediate states that drive inflammatory activation during aging. We utilize scRNA-Seq across the adult lifespan to identify intermediate transcriptional states of microglial aging that emerge following exposure to an aged systemic environment. Functionally, we tested the role of these intermediate states using in vitro microglia approaches and an in vivo temporally controlled adult microglia-specific Tgf ..read more

Intravenous, high-dose AAV gene therapy to upregulate VEGF has been shown to extend life in mice. This is perhaps a demonstration of the importance of loss of capillary density in tissue as a result of age-related disruption to angiogenesis, the multi-step process by which new blood vessels branch from existing vessels. Upregulation of VEGF is one of the possible approaches to restoring maintenance of capillary networks via improved angiogenesis, as VEGF is one of the important signal molecules involved in this process. A similar AAV gene therapy is being assessed in clinical trials for the tr ..read more

In conclusion, we found that elevated central aortic stiffness is associated with a greater decline in kidney function in old age. Since aPWV and cSBP both appear to be predictors of eGFR decline, it might be of interest to identify older individuals with elevated aortic stiffness. In this specific population, intensive blood pressure reduction might be justified in order to slow down the process of vascular aging and prevent kidney function decline. « Back to Top Cellular Senescence in Neurodegenerative Conditions https://www.fightaging.org/archives/2024/04/cellular-senescence-in-neurodegener ..read more