PAS report 2024: Clinical Trials part 1.
Neonatal Research
by Keith Barrington
1d ago
As usual the PAS meeting was packed with neonatology. The App was even worse than last year, crashing frequently on many peoples’ phones. It was completely useless for the posters, as they were listed by number, and the different sessions ..read more
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Not neonatology. Birding in western Ontario
Neonatal Research
by Keith Barrington
1d ago
On my way to the PAS annual meeting in Toronto, I decided to spend a couple of days at Point Pelee national park. It is the southern-most point of Canada, a peninsula jutting out into lake Erie that is a ..read more
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When you can see what you are doing, you can see what you have done: Video-Laryngoscopy in the newborn
Neonatal Research
by Keith Barrington
1d ago
I have been increasingly using video laryngoscopy in my practice, both when I myself perform the intubation, and when I am supervising a resident or other trainee. I usually ask them to use a VL when it is a nurse ..read more
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How should we pasteurize donor breast milk?
Neonatal Research
by Keith Barrington
2w ago
The standard method of pasteurization of donor breast milk, and I believe the only method approved by HMBANA (the human milk banking association of north america), is similar to what Louis Pasteur himself came up with a couple of centuries ..read more
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Oxygen is toxic in older kids too!
Neonatal Research
by Keith Barrington
2M ago
A new large RCT from PICUs in the UK randomly compared 2 saturation target ranges, 88-92 and >94%. Children <16 years of age being ventilated with supplemental oxygen were randomized within 6 hours of admission. The intervention stopped when the ..read more
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Donor human milk, not toxic after all!
Neonatal Research
by Keith Barrington
3M ago
It was fairly recently that I deconstructed a truly terrible database analysis which claimed that neonatal mortality was dramatically increased among very preterm infants who received mother’s own milk (MoM) and donor human milk (DHM), without any formula or fortifier ..read more
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Is there any indication to close the PDA?
Neonatal Research
by Keith Barrington
3M ago
Yet another trial of PDA treatment and attempted closure with a null result. Baby-OSCAR was a UK multi-center masked RCT of ibuprofen treatment of 23 to <29 week infants who were screened with echocardiogram within the first 72 hours of ..read more
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Time to open the DOOR
Neonatal Research
by Keith Barrington
4M ago
I have written many times about the problems with classical composite outcomes in neonatal research. “Death or BPD”, “death or NDI”, or sometimes “death or NEC or Sepsis or BPD or severe IVH” have been used as a way of ..read more
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Early routine surfactant, method and outcomes
Neonatal Research
by Keith Barrington
5M ago
Two important new studies of the use of very early routine surfactant, compared to later selective surfactant if necessary. The first I will discuss is the one that didn’t seem to improve any important clinical outcomes (Murphy MC, et al ..read more
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Umbilical cord management at birth for preterm infants
Neonatal Research
by Keith Barrington
6M ago
The Lancet just published back-to-back articles from the iCOMP collaborative reporting the results of the Individual Patient Data Meta-analysis of trials of differing cord management techniques in preterm infants. There were 48 trials with a total of 7000 patients in the IPD which made 3 comparisons Delayed compared to immediate clamping, and each approach compared ..read more
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