..read more

Your Brain is Lying to You—Here’s How to Take Back Control  Every day, your brain is running subconscious scripts—hidden mental loops that shape your decisions, habits, and even your self-worth. But what if those loops are sabotaging you?  In this episode, Bizzie Gold, mind architect and creator of The Break Method, joins Dave Asprey to expose the self-deception patterns controlling your thoughts—and how to reprogram your brain for true transformation.  Bizzie’s method isn’t just another self-help philosophy. It’s science-backed, no BS, and eng ..read more

Is the Way You Speak Limiting How You Think? For years, scientists debated how language shapes the brain, but new research reveals it goes far beyond communication. Some languages lack numbers, grammar, or even complex sentences—yet their speakers navigate reality in ways that defy expectations. In this mind-bending episode, linguist Daniel Everett, known for challenging Noam Chomsky’s theories, shares how his time with the Pirahã people reshaped our understanding of language, cognition, and even consciousness. If language rewires thought, what happens when AI starts using it? Can a machine tr ..read more

For decades, we’ve been told that our DNA is a fixed blueprint—an unchangeable code that dictates our health and lifespan. But what if that’s only half the story?  Sharon Hausman-Cohen, a physician, researcher, and genomics expert at IntellxxDNA, joins Dave to reveal the cutting-edge science of genetic optimization—how understanding your DNA can unlock longer life, better brain function, and even protection from chronic disease.  Forget the old-school genetic reports that left you with useless percentages. The new frontier of precision genomics goes beyond risk fa ..read more

For years, we’ve been told that willpower and repetition are the keys to forming habits. But the truth is, habits don’t stick because of repetition—they stick because of emotion!  In this all-time classic episode, Dave brings together two of the world’s top habit experts—BJ Fogg, PhD, and James Clear—to break down the real science of behavior change. BJ, the Stanford researcher behind Tiny Habits, explains why motivation, ability, and the right prompts are the real drivers of habits. Meanwhile, Atomic Habits author James Clear reveals how small decisions compound over ..read more

In this first-ever AMA episode, Dave tackles your biggest biohacking questions—straight from The Upgrade Collective! From optimizing brain power to pushing the limits of cold therapy, this episode is packed with cutting-edge hacks to supercharge your body and mind. If you’d like to have your questions answered on the next AMA, click the link below for details on The Upgrade Collective membership, and get all sorts of extra biohacking add-ons for your life!  In today’s episode: What if you could amplify oxytocin—the “love hormone”—to build stronger relationships and lower stress ..read more

Can You Mimic Fasting—Without Actually Fasting?  Chris Rhodes, a biochemist and longevity researcher, joins Dave to reveal a groundbreaking fasting mimetic that could revolutionize how we approach aging, metabolism, and health.  Fasting is one of the most powerful tools for longevity, but what if you could achieve the same benefits without hunger, energy crashes, or social sacrifices? Scientists have identified key compounds that mimic fasting at the cellular level—offering a way to extend lifespan, boost metabolism, and enhance cognitive function without giving up food.&nb ..read more

Could a single molecule be the difference between vibrant longevity and early decline?  Dr. Andy Salzman—Harvard-trained physician, scientist, and creator of the first PARP1 inhibitor—joins Dave to reveal the real key to living longer, fighting disease, and maximizing your energy: NAD.  This master molecule fuels your mitochondria, DNA repair, and cellular resilience, but here’s the catch—it plummets as you age. That means more fatigue, brain fog, inflammation, and higher risks of disease. But what if you could stop the decline and even reverse it?  ..read more

Welcome to the metabolism masterclass! Dr. Ben Bikman (Ph.D Professor BYU), a powerhouse in metabolism science, joins Dave to expose the truth about insulin resistance—the silent epidemic fueling obesity, chronic disease, and low energy. Forget the outdated calorie-counting nonsense (it doesn’t work)—Dr. Bikman reveals how your hormones, not just your diet, control your metabolism and what you can do to reset it fast.  From debunking diet myths to uncovering why some people can eat 400 grams of carbs and never gain fat (hint: it’s not what you think), this episode ..read more

Most people wait for inspiration. But what if you could train your brain to create on demand?  Rick Rubin has spent decades shaping the sound of legendary artists—Jay-Z, Johnny Cash, Metallica, and countless others—by tapping into the unseen forces of creativity. But what’s the secret behind his genius?  In this must-listen episode, Rick sits down with Dave to explore the science and soul of creativity, revealing how meditation, mindfulness, biohacking, and unconventional thinking fuel artistic breakthroughs. From rewiring your brain with meditation to stacking biohacks for peak ..read more