The combination of paracetamol, ibuprofen, and dexamethasone resulted in lower morphine consumption and pain levels within 24 hours after receiving a total hip arthroplasty (THA), along with fewer adverse events (AEs), compared with other combinations, according to study results published in The Lancet Rheumatology. While multimodal analgesia in combination with nonopioid medications is advocated for pain management following THA, the optimal regimen remains elusive. Researchers aimed to fill this gap by investigating various combinations of oral paracetamol, oral ibuprofen, and a single perio ..read more

Greater consumption of fatty acids and higher levels of omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) in erythrocytes were associated with a modestly greater risk for total hip arthroplasty (THA) among older women, according to results of a prospective analysis published in Arthritis Care & Research (Hoboken). Due to the prevalence of severe osteoarthritis (OA) and the related need for joint replacement that is expected to accelerate in the next few decades, a pressing need exists to develop methods for preventing OA. Certain research supports the possibility that die ..read more

HealthDay News — Progressive resistance training (PRT) is not superior to neuromuscular exercise (NEMEX) for improving functional performance in patients with hip osteoarthritis (OA), according to a study published online April 9 in the Annals of Internal Medicine. Troels Kjeldsen, from Aarhus University Hospital in Denmark, and colleagues examined whether PRT is superior to NEMEX for improving functional performance in a superiority trial involving 160 patients with clinically diagnosed hip OA. The participants were randomly assigned to 12 weeks of PRT or NEMEX (82 and 78 individuals, respect ..read more

Osteoarthritis (OA) is the most common form of arthritis, primarily affecting the hips, knees, hands, and spine. The disease most often presents in adults aged at least 40 years, and prevalence generally increases with age. Osteoarthritis is 1 of the preeminent causes of long-term disability and chronic pain in adults.1,2 The 2021 Global Burden of Disease Study involved the compilation and analysis of health data from 204 countries and territories around the world, from 1990 to 2020. According to this study, around 595 million individuals worldwide lived with OA in 2020, equating to roughly 7 ..read more

Patients in the United States with nonalcoholic fatty liver disease (NAFLD) were more likely to have osteoarthritis (OA), according to study results published in Arthritis Research & Therapy. Researchers explored the relationship between NAFLD and OA among adults in the United States. They conducted a cross‑sectional study, with data taken from the 2017 to 2018 National Health and Nutrition Examination Survey cycle. The diagnosis of NAFLD was confirmed by vibration-controlled transient elastography, while the presence of OA was self-reported by patients. The study included 2622 participant ..read more

Genicular nerve radiofrequency ablation (GNRFA) for severe pain from knee osteoarthritis is as safe as intraarticular injection, according to results of a large retrospective cohort study published in Regional Anesthesia and Pain Medicine. However, rare adverse events such as venous thromboembolism (VTE) and septic arthritis may occur. Genicular nerve radiofrequency ablation, an emerging treatment for severe pain from knee osteoarthritis, has been shown to be safe and effective at enhancing function and reducing pain for 6 months or more. In rare cases, the procedure has been associated with s ..read more

In patients with knee osteoarthritis (OA), a higher dietary inflammatory index (DII®) score — reflective of a more proinflammatory diet — may be associated with increased pain and a higher risk for severe pain trajectory over a period of 10 years, according to study results published in Arthritis Care & Research. Implementing an anti-inflammatory diet may offer significant pain reduction benefits for older adults. Knee OA affects approximately 23% of individuals over the age of 40 worldwide, leading to pain and a diminished quality of life. Inflammation plays a crucial role in knee OA, and ..read more

Serum levels of eicosapentanoic acid (EPA) and other specific n-3 or n-6 fatty acids (FAs) were not associated with the risk for incident knee osteoarthritis (OA) or other OA outcomes, according to study results published in Arthritis Care & Research. The n-6 and n-3 polyunsaturated FAs (PUFAs) are essential for the synthesis of eicosanoids, as they signal molecules that influence inflammation. In the context of OA, the anti-inflammatory effects of n-3 PUFAs, such as EPA and docosahexanoic acid (DHA), are notable. Investigators conducted a nested case-control study to assess the impact of ..read more

The American Academy of Orthopaedic Surgeons (AAOS) recently released updated guidelines for the management of hip osteoarthritis (OA). The full report has been published on the organization’s official website.1 The updated guidelines are a revision of the 2017 edition, introducing modifications to 14 of the 23 evidence-based recommendations for the nonoperative treatment of hip OA in adults. These revisions yielded 3 strong recommendations, 5 moderate recommendations, and the remaining were of limited nature. 2 The guidelines covered various recommendations supported by substantial evidence ..read more

The negative impact of depression on physical function may diminish as knee osteoarthritis (OA) progresses, according to study results published in Arthritis Care & Research. While previous studies have assessed the negative impact of knee OA on physical function, they have not explored how changes in depressive symptoms can affect function over time. It is crucial to understand the long-term outcomes associated with this comorbidity to provide better care for patients with knee OA. Therefore, researchers used data from the prospective, observational Osteoarthritis Initiative (OAI) cohort ..read more