In Aging Cell, researchers have published evidence that downregulating a key aspect of lipid metabolism harms mitochondrial function, but only in cells taken from younger people. Fat regulation at the cellular level Perilipins (PLINs) are proteins that regulate the use of fats (lipids) within cells. This paper focuses on PLIN2, which has previously been investigated in the context of aging [1] and plays a significant role in lipid metabolism [2]. PLIN2 plays a role in diabetes [3] and has been investigated in cancer, although its role varies by the cancer type [4]. Why we Age: Mitochondria ..read more

Berlin’s event landscape is growing: Longevity Week will take place in the German capital for the first time from May 6-12, 2024. The opening event will take place on May 6th at the Langenbeck-Virchow-Haus in Berlin Mitte near the Charité hospital. A total of 15 events will be organised throughout the city. Speakers include, among others, Prof. Eric Verdin, CEO of the renowned Buck Institute; Michael Greve from Kizoo Technology Capital; and Dr. Ina Czyborram, Senator for Science, Health, and Care of the State of Berlin. Longevity Week is organised by a consortium of founders, doctors and long ..read more

Scientists have discovered that frequently interrupting prolonged sitting with physical activity, such as short walks or squats, can help control glucose levels in overweight and obese males [1]. Don’t just sit there! Prolonged sitting is the curse of modern times. It has been associated with various health problems, such as diabetes, poor heart health, weight gain, depression, dementia, and cancer. In overweight and obese people, sedentary lifestyle prevents calorie burning. It is a well-known recommendation to interrupt prolonged sitting with bouts of physical activity [2], but the actual e ..read more

The authors of a recent paper published in GeroScience used an alternative statistical test to reanalyze data from the Interventions Testing Program and identified additional life‑extending compounds [1]. The crucial step of data analysis A typical biological experiment can be divided into three stages: planning, executing, and results analysis. The last part can be done in multiple ways, such as by using different statistical methods to focus on different outcomes. The authors of a recent paper decided to use the data from The National Institute on Aging’s Interventions Testing Program (ITP ..read more

On the tropical island of Roatán, a bunch of people gathered in an unprecedented, longevity-themed pop-up city – and then some of them stayed, making the venture permanent. “You’re going where?” A friend invited me over, but I declined, telling him I had to travel for work again. “Where to this time?” he asked with a hint of envy, us being stuck in the middle of Seattle’s infamously gloomy winter. “Honduras,” I said. He fell silent for a second and then asked cautiously: “What exactly does Honduras have to do with aging biology?” A fair question. Last year, my work took me to another unlikely ..read more

According to a new study, cannabis consumption is associated with increased risks of coronary heart disease, stroke, and heart attack [1]. It’s growing popular, but is it good for you? After decades of being banned and demonized, marijuana is making a huge comeback, thanks to a wave of legalization or decriminalization. Currently, weed is legal in 24 US states, almost half of the nation, and in several countries around the world. This is coinciding with an unprecedented decline in tobacco use, which is probably the best thing that has happened in public health in decades. However, there’s an ..read more

With an in-depth examination tool in hand, researchers publishing in Aging have done a preliminary examination of the muscle protein differences between younger and older people and how older people’s proteins change with exercise. The power to take a close look This paper begins with a discussion of proteomics, the science of analyzing what proteins a tissue expresses. These researchers hold that proteomics is naturally more representative of physical processes in tissues than other -omics approaches, such as genomics [1]. However, analyzing muscle tissue in this way is tricky, as common tec ..read more

Epigenetic aging measurements can vary by the time of day at which they are taken, according to a study published in Aging Cell. The circadian rhythm Living on Earth, organisms have evolved to adapt to our planet’s day/night cycle. This adaptation is known as the circadian rhythm, and it influences many aspects of biology. As these researchers [1] and others have found, this even includes the number of white blood cells circulating in the bloodstream. Because different white blood cells often have different measured epigenetic ages, measuring the total epigenetic age of white blood cells can ..read more

Tiny bubbles that cells use to communicate with each other prolonged lifespan and reversed numerous aging phenotypes when taken from young mice and injected into old ones, even though the treatment started late in life [1]. The tiny messengers For millennia, humans credited young blood with rejuvenating qualities. This belief caused legendary and historic rulers to commit atrocities to get enough of this “elixir of youth”. While these ideas were delusional and barbaric, science has confirmed that there is some truth to them. Research into heterochronic parabiosis, which involves connecting th ..read more

A study published in Aging Cell has reported that older people with better regulated autophagy in their skeletal muscles have less age-related frailty. Taking out the trash What is Autophagy? Autophagy, derived from ancient Greek, means "eating of self". Autophagy is the way cells break down misbehaving or nonfunctional organelles and proteins in the cell. This means that autophagy can consume organelles, such as mitochondria, peroxisomes, and the endoplasmic reticulum. Despite its noxious-sounding name, autophagy serves more of a protective role than a harmful one. Read More The research ..read more