Islet Autoimmunity Linked to COVID-19 in Children Susceptible to Type 1 Diabetes
Endocrinology Advisor » Type 1 Diabetes
by Aleta Terrill
6M ago
Islet autoimmunity is associated with COVID-19 infection in children at increased genetic risk for type 1 diabetes, according to results of a study published in JAMA. Researchers sought to assess the temporal association between COVID-19 infection and the development islet autoimmunity — a precursor for type 1 diabetes — in early childhood. Between April 2019 and June 2022, 885 infant participants (441 girls; age range, 4.0-7.0 months) with high genetic susceptibility to type 1 diabetes were evaluated, all of whom tested negative for islet autoantibodies at baseline. Participants were included ..read more
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Type 1 Diabetes in Children, Adolescents Increased During Pandemic
Endocrinology Advisor » Type 1 Diabetes
by Haymarket Media
9M ago
HealthDay News — The incidence rates of type 1 diabetes in children and adolescents increased after the start of the COVID-19 pandemic, according to a review published online June 30 in JAMA Network Open. Daniel D’Souza, from the SickKids Research Institute in Toronto, and colleagues conducted a systematic literature review and meta-analysis to compare the incidence rates of pediatric diabetes during and before the COVID-19 pandemic (Jan. 1, 2020, to March 28, 2023). Based on 42 studies (102,984 youths), the researchers found that for type 1 diabetes, there were higher incidence rates dur ..read more
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FDA Approves Lantidra, a Cellular Therapy for Type 1 Diabetes
Endocrinology Advisor » Type 1 Diabetes
by Steve Duffy
9M ago
The Food and Drug Administration (FDA) has approved Lantidra (donislecel-jujn) for the treatment of type 1 diabetes in adults who are unable to approach target HbA1c due to current repeated episodes of severe hypoglycemia despite intensive diabetes management and education. Treatment is to be used in conjunction with concomitant immunosuppression. Lantidra is the first FDA-approved allogeneic pancreatic islet cellular therapy. It is believed to work through the secretion of insulin from the infused allogeneic islet beta cells. Treatment is administered as a single infusion into the hepatic por ..read more
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Accommodative Function May Be Affected By Type 1 Diabetes
Endocrinology Advisor » Type 1 Diabetes
by Jessica Nye
9M ago
Accommodative function, particularly accommodative insufficiency, may be worsened by type 1 diabetes (T1D), according to a study published in Ophthalmic and Physiological Optics. T1D may also affect other accommodative parameters, which include accommodative amplitude, accommodative facility, and negative relative accommodation, according to the report. Researchers included individuals with T1D (n=30; mean age, 22.90 years; 60% men) and control group participants (n=30; mean age, 23.67 years; 63% men) without presbyopia or retinopathy in the comparative, cross-sectional investigation. All part ..read more
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Medtronic’s MiniMed 780G System Approved for Patients With Type 1 Diabetes
Endocrinology Advisor » Type 1 Diabetes
by Diana Ernst, RPh
11M ago
The Food and Drug Administration (FDA) has approved the Medtronic MiniMed 780G system with the Guardian 4 sensor for patients 7 years of age and older with type 1 diabetes. In addition to continuous glucose monitoring (CGM), the advanced hybrid closed-loop (AHCL) system continuously delivers basal insulin at selectable rates and issues correction insulin boluses without user input. Using the Company’s SmartGuard technology, the MiniMed 780G system can be programmed to adjust insulin delivery based on CGM sensor glucose values and features a default glucose target setting of 100mg/dL (with the ..read more
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Closed-Loop Glucose System Beneficial for Younger Children With Type 1 Diabetes
Endocrinology Advisor » Type 1 Diabetes
by Haymarket Media
1y ago
HealthDay News — For young children with type 1 diabetes, a closed-loop glucose system results in a higher percentage of time that the glucose level is in the target range, according to a study published in the March 16 issue of the New England Journal of Medicine. R. Paul Wadwa, M.D., from the University of Colorado in Aurora, and colleagues randomly assigned 102 children who were at least 2 years of age but younger than 6 years with type 1 diabetes to receive treatment with a closed-loop system of insulin delivery or standard care, including either an insulin pump or multiple daily inje ..read more
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Verapamil Partially Preserves C-Peptide Secretion in Children With T1DM
Endocrinology Advisor » Type 1 Diabetes
by Haymarket Media
1y ago
HealthDay News — Verapamil partially preserves stimulated C-peptide secretion at 52 weeks after diagnosis among children with newly diagnosed type 1 diabetes, according to a study published online Feb. 24 in the Journal of the American Medical Association. Gregory P. Forlenza, M.D., from the University of Colorado in Aurora, and colleagues examined the effect of verapamil on pancreatic beta cell function in children aged 7 to 17 years with newly diagnosed type 1 diabetes. Participants were randomly assigned to once-daily oral verapamil or placebo (47 and 41 patients, respectively); 83 par ..read more
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Over 60% of Adults With Type 1 Diabetes Have Overweight, Obesity
Endocrinology Advisor » Type 1 Diabetes
by Haymarket Media
1y ago
HealthDay News — Rates of overweight and obesity in adults with type 1 diabetes are similar to rates in the general population, while those with type 1 diabetes are least likely to increase physical activity or reduce caloric intake to manage overweight or obesity, according to a research letter published online Feb. 14 in the Annals of Internal Medicine. Michael Fang, Ph.D., from the Johns Hopkins Bloomberg School of Public Health in Baltimore, and colleagues characterized the prevalence and management of overweight and obesity among adults with type 1 diabetes versus the general populat ..read more
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Self-Stigma Linked to HbA1c in Adults With Type 1 Diabetes
Endocrinology Advisor » Type 1 Diabetes
by Haymarket Media
1y ago
For adults with type 1 diabetes, there is a significant association between self-stigma and hemoglobin A1c (HbA1c ..read more
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Is There an Association Between Type 1 Diabetes and Impaired Pulmonary Function?
Endocrinology Advisor » Type 1 Diabetes
by melissaalvarez
1y ago
Hypothesizing that the lung might be a target organ of type 1 diabetes, researchers reviewed literature connecting T1D and pulmonary function tests ..read more
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