Strategies for KRAS Research and Drug Discovery
The Active Motif Epigenetics Blog
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1y ago
RAS is one of the most common oncogenes, responsible for 20-30% of all human cancers, with KRAS being responsible for most of these. Current research has mostly focused on targeting KRAS mutants, but it’s only been in the last decade that we’ve seen development of methods to directly inhibit mutant KRAS. With new insight into mechanisms behind KRAS activation there is an ever-expanding pipeline of potential drugs which may change the way these dangerous cancers are treated. Here we provide a look at the history of RAS family proteins in the context of mutations and potentially targets to mitig ..read more
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African Turquoise Killifish – A Colorful Up-and-Coming Model in Aging Research!
The Active Motif Epigenetics Blog
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1y ago
The connection between epigenetics, cell senescence and aging continue to grow. As the field expands, so does the range of organisms we’re finding well-suited for the task. Here we present a roundup of all recent protocols and research concerning the African turquoise killifish and its potential as a model for aging. This up-and-coming model may be everything you need for your aging-based research ..read more
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Mass Spectrometry – Attaining Massive Amounts of Histone Modification Data from Small Clinical Samples
The Active Motif Epigenetics Blog
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1y ago
A new advance now permits the profiling of histone modifications from vanishingly small amounts of clinical samples via mass spectrometry. The ability to profile histone modification levels in tumor subpopulations may permit the field to make massive strides forward in our understanding of tumor metastasis, intratumor heterogeneity, therapeutic responses by tumors, and the role of tumor subpopulation interactions in driving tumorigenesis and identifying potentially useful biomarkers ..read more
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Inflammaging – What Epigenetic Associations with Kidney Health Can Tells Us
The Active Motif Epigenetics Blog
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1y ago
Inflammaging is a somewhat new, but very engaging concept – how does our immune system affect the aging process? Here we look at research describing how accelerated epigenetic aging detected in the blood correlates with reduced kidney health as an example. These links may provide a means to further our understanding of inflammaging, and how to combat this chronic low-grade inflammatory process that may contribute to age-related disease development ..read more
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Single-Cell DNA Methylation Sequencing: Small Scale Differences Explain Big Effects!
The Active Motif Epigenetics Blog
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1y ago
As an epigenetic mark, DNA methylation reveals valuable information on what’s going on inside a cell. In traditional bulk sequencing methods, DNA methylation signals are averaged out so that cell to cell variability in methylation is lost. Single-cell methods for DNA methylation can reveal these hidden signatures. But gathering DNA methylation data on a single-cell level has been challenging. Here we compare methods for scDNA Methylation assays that can uncover valuable insights into cell development, disease, and brain cell heterogeneity. As these have only been around for a short number of y ..read more
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LINE-1 Elements: Walk the LINE-1
The Active Motif Epigenetics Blog
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2y ago
While LINE-1 elements have been vital for fueling genetic variation and human evolution, their repression and that of other transposable elements is crucial to maintain homeostasis in cells so that our genomes continue to walk the line! Read how rogue LINE-1 expression is a target for combating its role in disease and aging ..read more
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Proteomics and Epigenetics – Two Worlds Collide to Describe Disease-Related Mechanisms
The Active Motif Epigenetics Blog
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2y ago
Researchers combine blood-based epigenetic and proteomic analysis to uncover the underlying disease-associated mechanisms ..read more
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Seeing the Bigger Picture – Spatially Resolving Chromatin Modification Profiles with Spatial-CUT&Tag
The Active Motif Epigenetics Blog
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2y ago
Spatial-CUT&Tag spatially resolves chromatin modification profiles in tissue samples to aid the exploration of epigenetic regulation, cell functions, and fate decisions ..read more
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DNA Modifications Reveal the Splendor of the Plant Epigenetic Landscape
The Active Motif Epigenetics Blog
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2y ago
Would you like to explore the color and beauty of the epigenetic landscape of plants? Begin your journey with a discussion of recent publications highlighting the ongoing discovery and importance of DNA modifications in various plant species ..read more
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ABBS – A Novel Method to Map DNA Methylation Genome-Wide at Base Resolution
The Active Motif Epigenetics Blog
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2y ago
Anchor-based bisulfite sequencing (ABBS) was developed for detection of DNA methylation genome-wide. ABBS is a new technology developed by Active Motif and recently described in ..read more
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