Ericka Samantha Teleg, MD Kuramatsu JB, Gerner ST, Ziai WC, Bardutzky J, Sembill JA, Sprügel MI, Mrochen A, Kölbl K, Ram M, Avadhani R, et al. Association of Intraventricular Fibrinolysis With Clinical Outcomes in ICH: An Individual Participant Data Meta-Analysis. Stroke. 2022. This meta-analysis examines the utilization of intraventricular fibrinolysis (IVF) and its impact on clinical outcomes in intracerebral hemorrhage. Despite several studies showing intraventricular clot resolution and safety among an intracerebral hemorrhage (ICH) population with a small hematoma volume but larger intrav ..read more

Prof. Dr. Matthias Endres A conversation with Prof. Dr. Matthias Endres, MD, Director of the Department of Neurology, Charité-Universitätsmedizin, Berlin, Germany, on neuro-immune crosstalk in ischemic stroke. Interviewed by Dr. Aurora Semerano, MD, Stroke Neurologist, San Raffaele Hospital, Milan, Italy (@semerano_aurora). They will be discussing the article “Immune Pathways in Etiology, Acute Phase, and Chronic Sequelae of Ischemic Stroke,” published in the April 15, 2022 issue of Circulation Research. Dr. Semerano: Your article is part of a Compendium ..read more

Ammad Mahmood, MBChB, BMedSci@AMahmoodNeuro A joint symposium between ESO and ESMINT discussed the challenges faced in acute reperfusion therapies, including patient selection and therapeutic targets. Endovascular thrombectomy for mid-sized artery occlusions – Raul Nogueira The importance of IV thrombolysis (IVT) therapy in this patient population was highlighted, and what constitutes mid-sized arteries considered. The anatomical variation of the M2 segment of the MCA makes this definition critical — there is generally agreement on EVT for clots in the proximal portion of larger M2 vessels. Th ..read more

Aurora Semerano, MD @semerano_aurora European Stroke Organisation Conference May 4-6, 2022 Among other themes, this year ESOC has represented a unique opportunity to discuss cancer-related stroke in a dedicated Scientific Session titled “Stroke, thrombosis and cancer,” chaired by Blanca Fuentes (Spain) and Leo Bonati (Switzerland). Indeed, cancer is recently emerging as a risk factor for arterial thromboembolism, including stroke. Among ischemic stroke patients, comorbid cancer is a devastating condition associated with increased stroke severity, disability, and mortality. Importantly, the opt ..read more

Tolga D Dittrich, MD @to_dittrich European Stroke Organisation Conference May 4-6, 2022 The session chaired by William Whiteley (UK) and Iris Grundwald (UK) focused on current applications and possible future areas of utilization of artificial intelligence (AI) in the field of stroke. Helle Collatz Christensen from Denmark gave the opening lecture on early stroke detection in the emergency setting. Since experience has shown that emergency medical services do not always correctly recognize a relevant proportion of stroke symptoms at an early stage, the question for Professor Christensen was ho ..read more

Andy Lim, MBA, FACEM, GAICD @ALim0211 ESOC 2022 Amphithéâtre, Centre de Congrès de Lyon, Wednesday, 4 May 2022, 10:30 – 12:30 CEST Here we are, officially welcomed to the 8th European Stroke Organisation Conference! Results of nine large trials were released this morning, and social media is already buzzing with excitement from these results. Here are the key findings for those who might have missed out. Three tenecteplase trial results were released today. The AcT trial, a Canadian trial of 1600 patients with acute stroke, demonstrated that tenecteplase was noninferior (5% margin) to altepla ..read more

Praveen Hariharan, MD Buckley BJR, Harrison SL, Hill A, Underhill P, Lane DA, Lip GYH. Stroke-Heart Syndrome: Incidence and Clinical Outcomes of Cardiac Complications Following Stroke. Stroke. 2022. Over the last two decades, an increasing body of evidence has recognized various cardiovascular complications following ischemic stroke collectively known as the stroke-heart syndrome. Ischemic stroke can cause impaired autonomic cardiac reflexes, repolarization abnormalities, myocardial injury and cardiomyopathy resulting in myocardial infarction, cardiac arrhythmias including atrial fibrillation ..read more

Kevin O’Connor, MD Beslow LA, Agner SC, Santoro JD, Ram D, Wilson JL, Harrar D, Appavu B, Fraser SM, Rossor T, Torres MD, et al. International Prevalence and Mechanisms of SARS-CoV-2 in Childhood Arterial Ischemic Stroke During the COVID-19 Pandemic. Stroke. 2022. Over the last two years, data have shown an increased risk of ischemic stroke in the setting of SARS-CoV-2 infection. Beslow et al. explored the relationship between SARS-CoV-2 and childhood (age 29 days to 18 years) ischemic stroke based on data from multiple sites across 21 countries. The sites reported 373 acute ischemic strokes f ..read more

Hannah Roeder, MD, MPH Hahn M, Gröschel S, Hayani E, Brockmann MA, Muthuraman M, Gröschel K, Uphaus T, on behalf of the German Stroke Registry—Endovascular Treatment (GSR-ET) Study Group. Sex Disparities in Re-Employment in Stroke Patients With Large Vessel Occlusion Undergoing Mechanical Thrombectomy. Stroke. 2022. For working-age stroke patients, returning to work (RTW) is a yardstick for functional recovery and is associated with improved well-being. Patients who suffer large vessel occlusion (LVO) are at greater risk for persistent neurological deficits; however, in the mechanical thrombec ..read more

Tolga D Dittrich, MD @to_dittrich Wagner B, Lorscheider J, Wiencierz A, Blackham K, Psychogios M, Bolliger D, De Marchis GM, Engelter ST, Lyrer P, Wright PR, et al. Endovascular Treatment for Acute Ischemic Stroke With or Without General Anesthesia: A Matched Comparison. Stroke. 2022. Endovascular treatment (EVT) effectively treats acute ischemic stroke and has gained increasing importance over the last few years. An important peri-procedural question is the choice of anesthesia type, especially whether conscious sedation (CS) is preferable to general anesthesia (GA). The current recommendatio ..read more