Are prematurely aged or overworked stem cells a significant factor in chronic lung disease? Findings of a study just released in STEM CELLS Translational Medicine (SCTM) say this is likely so. The study determined that repeated injury to the epithelial tissue of the airways causes “biological aging” of the stem cells located there. “This premature aging of ..read more

Screening possible immune functions related to anticancer treatmentCommon immune checkpoints were browsed and screened for possible immunotherapeutic value, and the representative immune checkpoint molecules13,14,15 ADORA2A, BTLA, Nectin-2 (CD112), CD160, CD244, PD-L1, CD96, CSF1R, CTLA4, HAVCR2, IDO1, IL10, IL10RB, KDR, KIR2DL1, KIR2DL3, LAG3, LGALS9, PDCD1, PDCD1LG2, PVRL2, TGFB1, TGFBR1, TIGIT, VTCN1, TNF Receptor Superfamily Member 14 ..read more

Dear Editor,Up to now, hematopoietic stem cells (HSCs) that contribute to all mature blood cell lineages in adults still cannot be efficiently regenerated in vitro, at least in part due to the insufficient understanding of their physiological developmental trajectories and the underlying precise regulatory mechanisms. In mouse embryos, the first HSCs are believed to be ..read more

I’ve been busy recently focusing more on grant and paper writing than reading papers on stem cells, but my piece on trying to de-extinct mammoths via cloning-like methods drew strong opinions on both sides.Recent news and resources on stem cellsWe’re still awaiting a verdict in the big California federal court case where the FDA is seeking a ..read more

Credit: ShutterstockLike a headline from the Onion, I recently read an email describing a big orthopedic surgery conference where a panel was sourced on whether or not you needed ultrasound guidance to inject a knee. While the result of this panel was a LOL moment for many of my colleagues, none of us really knew ..read more

1.Chaffer, C. L. & Weinberg, R. A. A perspective on cancer cell metastasis. Science 331, 1559–1564 (2011).CAS  PubMed  Article  PubMed Central  Google Scholar  2.Tseng, P.-L. et al. The decrease of glycolytic enzyme hexokinase 1 accelerates tumor malignancy via deregulating energy metabolism but sensitizes cancer cells to 2-deoxyglucose inhibition. Oncotarget 9, 18949–18969 (2018).PubMed  PubMed Central  Article  ..read more

Newswise — Researchers from the group of Hans Clevers in collaboration with the group of Bart Haagmans (Erasmus MC) established an organoid biobank to search for the genes that are essential for the spreading of a SARS-CoV2 infection. Their study was published in Nature Communications on 17 September and highlights the usefulness of organoids for ..read more

TreeFrog Therapeutics has raised $75 million in financing to support the clinical development of its stem cell-derived cell therapies for Parkinson’s disease, the company said in a press release.The new financing round, which brings the total funding to date to $83 million, will allow the company to use its C-Stem technology to expand the growth of ..read more

Credit: ShutterstockDoes amniotic tissue help knee arthritis pain? That’s been an open question for some time. Thankfully this question is beginning to get answered by FDA clinical trials, the earliest of which are now beginning to report results. One such report this week could spell trouble for the other half dozen companies involved in knee ..read more

Stem cell therapy is one of the most well-known and high-profile forms of medical treatment. For decades, medical researchers have used stem cell therapy to treat a myriad of conditions. However, stem cell therapy is growing in popularity and accessibility. As a result, more and more people may wonder if stem cell therapy is right ..read more