Incorporating fibroblasts into patient-derived organoids
Infectious Diseases Hub
by Aisha Al-Janabi
4M ago
Maria Ramos is a postdoc in the Bodenmiller Lab at the University of Zurich (Switzerland) using organoids to study cellular communication between cancer cells and the tumor microenvironment. At this year’s ELRIG Drug Discovery conference, Maria discussed her research on developing complex ecosystems with patient-derived organoids and Trellis, an algorithm developed to analyze large datasets obtained from single-cell mass cytometry. Our Content Editor Aisha Al-Janabi caught up with Maria at ELRIG to find out more. What are the key takeaways from your talk at ELRIG? My talk is about my PhD in t ..read more
Visit website
I can hear where you’re looking
Infectious Diseases Hub
by Beatrice Bowlby
4M ago
Researchers have discovered that the subtle squeaking sounds in the ear generated by eye movements can indicate where the eyes are looking.   In 2018, a team at Duke University (NC, USA) led by Jennifer Groh discovered that the ears make an imperceptible sound when the eyes move. 5 years later, the team has now found that these ear noises can indicate where your eyes are looking. It also works the other way; by knowing where the eyes are looking, the researchers could predict the waveform composition of the sound generated in the ear. Groh believes that these subtle squeaking sounds in t ..read more
Visit website
Ingestible device measures heart and breathing rate
Infectious Diseases Hub
by Aisha Al-Janabi
4M ago
A new ingestible device detects breathing depression, which could help monitor people with sleep apnea or at risk of opioid overdose. Researchers from the Massachusetts Institute of Technology (MIT; MA, USA), Celero Systems  (MA, USA) and West Virginia University (WV, USA) have collaborated to develop the first ingestible electronic device that can measure heart and breathing rate from inside the gastrointestinal (GI) tract. The device could be used to help diagnose and monitor people with sleep apnea or those at risk of an opioid overdose. "It's an exciting intervention to help people b ..read more
Visit website
How can plants ‘see’ the position of a light source?
Infectious Diseases Hub
by Aisha Al-Janabi
4M ago
Researchers have identified key structures in photosensitive plant tissue that allow them to determine the direction of light, leading to positive phototropism.   A recent research collaboration between École Polytechnique Fédérale de Lausanne (EPFL) and the University of Lausanne (UNIL; both Switzerland) has revealed a structural quirk of some plant tissues that allows them to determine the direction of light. By providing a clearer picture of the mechanism behind this process, the study, led by Christian Fankhauser (UNIL) and Andreas Schüler (EPFL), provides new avenues for exploration ..read more
Visit website
From the floor at Neuroscience 2023
Infectious Diseases Hub
by Annie Coulson
4M ago
At this year’s meeting of the Society for Neuroscience (SfN), Neuroscience 2023 (11–15 November; Washington DC, USA), we caught up with some of our industry partners to discuss their highlights and what they were presenting. Catch the videos below! We’re here #FromTheFloor at #SfN23 with @10xGenomics’ Spontaneous Russell talking about single-cell and #spatial technologies for neuroscientists ? pic.twitter.com/AN0YpR5T2F — BioTechniques (@MyBioTechniques) November 14, 2023 A joy to finally meet BioTechniques podcast regular Ritwika Biswas from @SinoInc! #FromTheFloor at #SfN23 pic.twitter.co ..read more
Visit website
Pathogenic role of metalloproteinases in cerebral SVD revealed
Infectious Diseases Hub
by Beatrice Bowlby
4M ago
A novel model of cerebral small vessel disease (SVD) reveals the pathogenic role of metalloproteinases (MMPs), pointing to a potential therapeutic target.   Researchers at the University of Cambridge (UK) have grown a model mimicking cerebral SVD, which is the leading cause of stroke and dementia, from skin biopsies. Using their model, the research team showed that a damaged extracellular matrix (ECM) surrounding the blood vessels contributes to leaky blood vessels, which can cause these cognitive diseases. Cerebral SVD contributes to 45% of dementia cases worldwide and 20% of ischemic s ..read more
Visit website
Quantifying protein aggregates with STAPull
Infectious Diseases Hub
by Aisha Al-Janabi
4M ago
A technique that can detect and measure small protein aggregates, which are hallmarks of numerous neurodegenerative diseases, has been developed. Protein aggregation – when proteins misfold and clump – is a characteristic of many neurodegenerative diseases, including Alzheimer's and Parkinson’s. Researchers at the University of Edinburgh (Scotland, UK), in collaboration with UCB Biopharma (Brussels, Belgium), have developed a technique called single-molecular two-color aggregate pull-down (STAPull) to detect and measure these protein aggregates more accurately. Oligomers are small protein agg ..read more
Visit website
Sophisticated artificial bladder model reveals cause of recurring UTIs
Infectious Diseases Hub
by Aisha Al-Janabi
4M ago
A novel 3D cell model has revealed that bacteria capable of hiding in the bladder wall may be a cause of ineffective diagnoses and treatment of UTIs. Researchers from UCL (London, UK) have developed robust 3D microtissue cell models to mimic the biological environment and function of human bladder tissue to closely observe host-pathogen interactions in conditions that represent the human body more accurately than traditional models. Using these models, the team uncovered diverse species/strain-specific infection strategies and corresponding host responses that suggest the current ‘one size fi ..read more
Visit website
In conversation with the Black Medical and Scientific Network
Infectious Diseases Hub
by Aisha Al-Janabi
4M ago
At ELRIG UK’s Drug Discovery Conference 2023, we spoke with the Founder of the Black Medical and Scientific Network Laura Eghobamien to find out more about why it was founded and what the network offers. Laura has a background in immunology and has worked in a number of different small biotech teams, developing cell-based assays for potential antibody-based drugs. In 2020, Laura founded the Black Medical and Scientific Network to provide support for marginalized students and professionals working in STEM. Could you tell me about the Black Medical and Scientific Network? It's a nonprofit organ ..read more
Visit website
Incucyte® applications: 3D cell culture
Infectious Diseases Hub
by Winifred Njambi
4M ago
In this compendium of applications, Sartorius demonstrate the power and flexibility of the Incucyte® Live-Cell Analysis System for the study of spheroids and organoids in foundational research, disease modeling and drug screening. [ui-tabs] [ui-tab title="Download now"] [/ui-tab] [ui-tab title="More information"] Organoids are rapidly becoming a powerful tool for both basic research and drug discovery, spanning a wide range of applications including oncology, regenerative medicine, disease modeling, and drug screening. These 3D organotypical structures can be grown in vitro to produce miniatu ..read more
Visit website

Follow Infectious Diseases Hub on FeedSpot

Continue with Google
Continue with Apple
OR