With ever-increasing life expectancy comes the challenge of treating age-related disorders such as osteoporosis. Although there are effective drugs for treating this metabolic bone disease, they can be expensive and have side effects, limiting their availability to some people. In the search for alternative drug candidates, researchers have discovered and fully replicated a compound from a botanical source, female ginseng, that had potent anti-osteoporotic activity in cellular tests ..read more

Research finds an overlap in the mechanism of hair color determination and bone resorption, which is associated with bone related diseases like osteoporosis. The findings revealed that proteins named Rab32 and Rab38 play pivotal roles in bone resorption in osteoclast, cell specialized in the process. These proteins are also crucial for pigmentation of hair and skins ..read more

Artificial intelligence has exploded in popularity and is being harnessed by some scientists to predict which molecules could treat illnesses, or to quickly screen existing medicines for new applications. Researchers have used one such deep learning algorithm, and found that dihydroartemisinin (DHA), an antimalarial drug and derivative of a traditional Chinese medicine, could treat osteoporosis as well. The team showed that in mice, DHA effectively reversed osteoporosis-related bone loss ..read more

Thousands of people could be spared from a hip fracture each year if a new method to identify the risk of osteoporotic fractures were to be introduced in healthcare. This is the view of the researchers who are behind a new 3D-simulation method ..read more

As life expectancy increases worldwide, age-associated diseases such as osteoporosis are having an increasing impact. Although early detection could help physicians intervene as soon as possible -- when treatment might offer the greatest benefit -- this type of detection is not yet possible with current osteoporosis diagnostic tests. Now, researchers have developed a biosensor that could someday help identify those most at risk for osteoporosis using less than a drop of blood ..read more

Scientists have pinpointed a key driver of low bone density, a discovery that may lead to improved treatments with fewer side effects for women with osteoporosis. The findings reveal that loss of an epigenetic modulator, KDM5C, preserves bone mass in mice. KDM5C works by altering epigenetic 'marks,' which are akin to 'on' and 'off' switches that ensure the instructions written in DNA are used at the right time and in the right place ..read more

People who have low bone density may have an increased risk of developing dementia compared to people who have higher bone density. The study does not prove that low bone density causes dementia. It only shows an association ..read more

Elevated levels of air pollutants are associated with bone damage among postmenopausal women, according to new research. The effects were most evident on the lumbar spine, with nitrous oxides twice as damaging to the area than seen with normal aging ..read more

Researchers identified an oral compound that influences components of the parathyroid hormone signaling pathway to increase bone formation and bone mass in mice ..read more

In our bones, specialized cells called osteoblasts are responsible for building up bone substance. A team of researchers has now identified an enzyme that controls the activity of osteoblasts. An agent that inhibits the activity of this enzyme reduced cancer-related bone loss and the number of bone metastases in multiple myeloma and in lung and breast cancer models in mice ..read more