Antivaxxers who "repurposed" deworming drugs like ivermectin and fenbendazole are peddling cancer "miracle cure" testimonials that remind me of laetrile and Stanislaw Burzynski. Truly, everything old is new again. The post Fenbendazole is fast becoming the laetrile of the 2020s first appeared on Science-Based Medicine ..read more

The controversial and never-proven-effective drug to treat Alzheimer's disease, aducanumab (Aduhelm) has been discontinued. The post Adios Aduhelm first appeared on Science-Based Medicine ..read more

SBM's guest contributor and ophthalmologist, Dr. David Weinberg, provides an update on the phase 3 trials of pegcetacoplan for macular degeneration. The results are still disappointing. The post Pegcetacoplan (Syfovre™) for macular degeneration: an update first appeared on Science-Based Medicine ..read more

Evidence-based medicine (EBM) has been a very useful paradigm for assessing evidence in medicine. However, like any other framework, it can be misused, particularly when fundamentalist EBM methodolatry leads to its inappropriate application to questions for which it is ill-suited, a misuse that has been weaponized against public health during the pandemic. The post 2023: The year that the evidence-based medicine (EBM) paradigm was weaponized against vaccines and public health first appeared on Science-Based Medicine ..read more

Calling a losing study a win. Making acupuncture great again. The post Make Acupuncture Great Again first appeared on Science-Based Medicine ..read more

A third drug either FDA approved or showing clinical benefit for Alzheimer's disease confirms that the world of AD treatment has changed forever. The post Yet Another Alzheimer’s Drug first appeared on Science-Based Medicine ..read more

A large randomized controlled trial of vitamin D supplementation generates good data to show there is likely no benefit. The post The effects of vitamin D supplementation on major cardiac events first appeared on Science-Based Medicine ..read more

Robert F. Kennedy, Jr. has resurrected the antivax claim that the childhood vaccine schedule has never been tested in randomized controlled trials (RCTs) with a saline placebo controls (and therefore the vaccine schedule is unsafe). This is an old and deceptive antivax half-truth that ignores both what constitutes a scientifically valid placebo and the ethical requirements for RCTs. The post RFK Jr. resurrects an old antivax half-truth about “saline placebos” in randomized controlled trials of vaccines first appeared on Science-Based Medicine ..read more

If I were King of the Vaccines. Some thoughts on influenza vaccine, hospitalization, death and courage. The post Courage first appeared on Science-Based Medicine ..read more

In February 2023, the US Food and Drug Administration (FDA) approved a new drug for the treatment of age-related macular degeneration (ARMD). The drug, pegcetacoplan (commercial name Syfovre™), is produced by Appelis Pharmaceuticals. This is the first drug approved for treatment of dry macular degeneration. Among eyecare specialists, enthusiasm around this event has been mixed. There is uncertainty about which patients should […] The post Pegcetacoplan, a new treatment for macular degeneration first appeared on Science-Based Medicine ..read more