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Alzheimer’s Incidence and Prevalence with and without Asthma: A Medicare cohort study

Journal of Allergy and Clinical Immunology

by Christie M. Bartels, Yi Chen, W. Ryan Powell, Melissa A. Rosenkranz, Barbara B. Bendlin, Joseph Kramer, William W. Busse, Amy Kind

1d ago

International data suggest that asthma, like other inflammatory diseases, might increase Alzheimer’s disease (AD) risk ..read more

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The Definition, Acronyms, Nomenclature, and Classification of Angioedema: AAAAI, ACAAI, ACARE, and APAACI DANCE Consensus

Journal of Allergy and Clinical Immunology

by Avner Reshef, Thomas Buttgereit, Stephen D. Betschel, Teresa Caballero, Henriette Farkas, Anete S. Grumach, Michihiro Hide, Ankur K. Jindal, Hilary Longhurst, Jonathan Peter, Marc A. Riedl, Yuxiang Zhi, Werner Aberer, Mohamed Abuzakouk, Tariq Al Farsi, Nashat Al Sukaiti, Mona Al-Ahmad, Sabine Altrichter, Emel Aygören-Pürsün, Maria Luisa Baeza, Noemi Anna Bara, Andrea Bauer, Jonathan A. Bernstein, Isabelle Boccon-Gibod, Hanna Bonnekoh, Laurence Bouillet, Zenon Brzoza, Anette Bygum, Oscar Calderon, Regis de Albuquerque Campos, Freya Helena Campos Romero, Mauro Cancian, Herberto Jose Chong-Neto, George Christoff, Stefan Cimbollek, Danny M. Cohn, Timothy Craig, Inna Danilycheva, Razvigor Darlenski, Aurélie Du-Thanh, Luis Felipe Ensina, Daria Fomina, Luz Fonacier, Atsushi Fukunaga, Asli Gelincik, Pedro Giavina-Bianchi, Kiran Godse, Mark Gompels, Margarida Goncalo, Maia Gotua, Guillermo Guidos-Fogelbach, Mar Guilarte, Alicja Kasperska-Zajac, Constance H. Katelaris, Tamar Kinaciyan, Pavel Kolkhir, Kanokvalai Kulthanan, Marcin Kurowski, Elena Latysheva, Antti Lauerma, David Launay, Ramon Lleonhart, William Lumry, Alejandro Malbran, Ramzy Mohammed Ali, Iman Nasr, Sandra Nieto-Martinez, Claudio Parisi, Ruby Pawankar, Macarena Piñero-Saavedra, Todor A. Popov, Grzegorz Porebski, Alicia Prieto Garcia, Polina Pyatilova, Michael Rudenko, Bulent Enis Sekerel, Faradiba Sarquis Serpa, Farrukh Sheikh, Frank Siebenhaar, Angèle Soria, Maria Staevska, Petra Staubach, Marcin Stobiecki, Simon Francis Thomsen, Massimo Triggiani, Anna Valerieva, Solange Valle, Nguyen Van Dinh, Carolina Elisa Vera Ayala, Anna Zalewska-Janowska, Andrea Zanichelli, Markus Magerl, Marcus Maurer

1d ago

Angioedema syndromes are clinically heterogeneous, hereditary, or acquired and caused by different pathogenetic mechanisms. The paper presents the results of a global expert consensus on the classification and terminology of various angioedema types and endotypes ..read more

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Antibiotics within first year are linked to infant gut microbiome disruption and elevated atopic dermatitis risk

Journal of Allergy and Clinical Immunology

by Courtney Hoskinson, Maria V. Medeleanu, Myrtha E. Reyna, Darlene LY. Dai, Biswajit Chowdhury, Theo J. Moraes, Piushkumar J. Mandhane, Elinor Simons, Anita L. Kozyrskyj, Meghan B. Azad, Charisse Petersen, Stuart E. Turvey, Padmaja Subbarao

1d ago

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A mutation in Themis contributes to anaphylaxis severity following oral peanut challenge in CC027 mice

Journal of Allergy and Clinical Immunology

by Ellen L. Risemberg, Johanna M. Smeekens, Marta C. Cruz Cisneros, Brea K. Hampton, Pablo Hock, Colton L. Linnertz, Darla R. Miller, Kelly Orgel, Ginger D. Shaw, Fernando Pardo Manuel de Villena, A. Wesley Burks, William Valdar, Michael D. Kulis, Martin T. Ferris

1d ago

The development of peanut allergy is due to a combination of genetic and environmental factors, although specific genes have proven difficult to identify. Previously, we reported that peanut-sensitized CC027/GeniUnc (CC027) mice develop anaphylaxis upon oral challenge to peanut, unlike C3H/HeJ (C3H) mice ..read more

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Distinct proteomes and allergen profiles appear across the life cycle stages of Alternaria alternata

Journal of Allergy and Clinical Immunology

by Michael Brad Strader, Aishwarya L. Saha, Chantal Fernandes, Kavita Sharma, Christian Hadiwinarta, Daniela Calheiros, Gonçalo Conde-de-Oliveira, Teresa Gonçalves, Jay E. Slater

1d ago

Alternaria alternata is associated with allergic respiratory diseases, which can be managed with allergen extract-based diagnostics and immunotherapy. It is not known how spores and hyphae contribute to allergen content. Commercial allergen extracts are manufactured by extracting proteins without separating the different forms of the fungus ..read more

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Can sputum eosinophils predict a poor response to mepolizumab?

Journal of Allergy and Clinical Immunology

by Catherine Lemiere, James G. Martin

1d ago

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Utility of eosinophil peroxidase as a biomarker of eosinophilic inflammation in asthma

Journal of Allergy and Clinical Immunology

by Monica Tang, Annabelle R. Charbit, Mats W. Johansson, Nizar N. Jarjour, Loren C. Denlinger, Wilfred W. Raymond, Michael C. Peters, Eleanor M. Dunican, Mario Castro, Kaharu Sumino, Serpil C. Erzurum, Suzy A. Comhair, Wendy C. Moore, Bruce D. Levy, Elliot Israel, Wanda Phipatanakul, Brenda R. Phillips, David T. Mauger, Eugene R. Bleecker, Sally E. Wenzel, Merritt L. Fajt, Prescott G. Woodruff, Annette T. Hastie, John V. Fahy, National Heart Lung and Blood Institute Severe Asthma Research Program

1d ago

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T-cell receptor sequencing in interrogating antigen-specific T-cell responses to foreign and self-antigens

Journal of Allergy and Clinical Immunology

by Alexandra M. Johansson, William W. Kwok

4d ago

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Inter-Alpha-Trypsin Inhibitor Heavy Chain 4 (ITIH4) as a Compensatory Protease Inhibitor in Hereditary Angioedema (HAE)

Journal of Allergy and Clinical Immunology

by Anne Troldborg, Zsofia Godnic-Polai, László Cervenak, Annette G. Hansen, Henriette Farkas, Steffen Thiel

4d ago

Hereditary angioedema (HAE) is a genetic disorder that manifests as recurrent angioedema attacks, most frequently due to absent or reduced C1 inhibitor (C1-INH) activity. C1-INH is a crucial regulator of enzymatic cascades in the complement, fibrinolytic, and contact systems. Inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) is an abundant plasma protease inhibitor that can inhibit enzymes in the proteolytic pathways associated with HAE. Nothing is known about its role in HAE ..read more

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Should ‘primary immune disorder’ replace ‘inborn error of immunity’? Names matter but there’s room for both

Journal of Allergy and Clinical Immunology

by Stuart E. Turvey, Catherine M. Biggs, Elliot L. James, Kyla J. Hildebrand

6d ago

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