Immune explains how aging influences chronic outcomes of respiratory viral infection through regulation of the alveolar macrophage compartment and type 2 inflammatory responses to viruses. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Click arrow to play Download Immune 54 (97 MB .mp3, 80 min) Subscribe (free): Apple Podcasts, Google Podcasts. RSS,  Become a patron of Immune! Links for this episode Age-dependent reduction in asthmatic pathology (J Immune) Time stamps by Jolene. Thanks! Music by Steve Neal. Imm ..read more

Immune reveals that marginal zone B cells steal complexes of MHC and complement C3 from dendritic cells for antigen presentation to T cells. Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker Click arrow to play Download Immune 53 (97 MB .mp3, 80 min) Subscribe (free): Apple Podcasts, Google Podcasts. RSS,  Become a patron of Immune! Links for this episode Trogocytosis in Immune 18 B cells steal from dendritic cells (Science) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immu ..read more

Gabriel Victora joins Immune to review how high affinity antibodies are produced in the germinal centers of secondary lymphoid tissues. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Gabriel Victora Click arrow to play Download Immune 52 (76 MB .mp3, 63 min) Subscribe (free): Apple Podcasts, Google Podcasts. RSS,  Become a patron of Immune! Links for this episode Concerto in B (TWiV 161) Visualizing antibody affinity maturation (Science) Restricted B cell clonality after boosting (Cell) Time stamps by ..read more

Nikhil Joshi joins Immune to discuss the creation of NINJA mice that synthesize neoantigens to enable the study of endogenous antigen-specific naïve T cell responses in disease and infection. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Nikhil Joshi Click arrow to play Download Immune 51 (76 MB .mp3, 63 min) Subscribe (free): iTunes, Google Podcasts. RSS,  Become a patron of Immune! Links for this episode Creation of NINJA mice (Nature Biotech) Time stamps by Jolene. Thanks! Music by Steve Neal. Im ..read more

Immune reviews evidence that toll-like receptor 9 on the surface of red blood cells binds DNA, leading to uptake by macrophages and innate immune activation. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Click arrow to play Download Immune 50 (57 MB .mp3, 94 min) Subscribe (free): iTunes, Google Podcasts. RSS,  Become a patron of Immune! Links for this episode DNA binding to TLR9 on red blood cells (Sci Transl Med) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Se ..read more

Keke Fairfax joins Immune to discuss the work from her laboratory on understanding how maternal schistosomiasis impairs IL-4 production and B cell expansion in offspring, and modulation of macrophage immunometabolism by helminths. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Keke Fairfax Click arrow to play Download Immune 49 (57 MB .mp3, 94 min) Subscribe (free): iTunes, Google Podcasts. RSS,  Become a patron of Immune! Links for this episode Maternal schistosomiasis impairs offspring immunity (PloS ..read more

Tim Hand joins Immune to discuss the work from his laboratory showing that environmental enteric dysfunction, a disease caused by chronic malnutrition and infection, and which is associated with reduced growth and oral vaccine failure, is controlled by an increase in intestinal regulatory T cells. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Timothy Hand Click arrow to play Download Immune 48 (45 MB .mp3, 75 min) Subscribe (free): iTunes, Google Podcasts. RSS,  Become a patron of Immune! Links for th ..read more

The immune professors discuss neutrophil extracellular traps, and how IgA-virus immune complexes potentiate this process through Fc receptors on neutrophils. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Click arrow to play Download Immune 47 (43 MB .mp3, 71 min) Subscribe (free): iTunes, Google Podcasts. RSS,  Become a patron of Immune! Links for this episode Antiviral IgA potentiates NETosis (PNAS) Letters read on Immune 47 Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen ..read more

Immune explore the observation that bat cells display dampened STING-dependent interferon activation, suggesting why bats might have a unique capacity to harbor many viruses. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Click arrow to play Download Immune 46 (50 MB .mp3, 84 min) Subscribe (free): iTunes, Google Podcasts. RSS,  Become a patron of Immune! Links for this episode Dampened STING in bats (Cell Host Micr) Lessons from bat defenses (Nature) Bat immune systems (Front Immune) Bats protected from gen ..read more

On this episode of Immune, we answer listener questions about CAR-Macs, complement and COVID-19, sleep and the immune system, caving and the immune system, germinal centers, COVID-19 vaccines and much more. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Click arrow to play Download Immune 45 (50 MB .mp3, 84 min) Subscribe (free): iTunes, Google Podcasts. RSS,  Become a patron of Immune! Links for this episode Letters read on Immune 45 Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by B ..read more