Immune - Vincent Racaniello
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A podcast on the host defense systems that protect against disease. Stephanie takes the Immune team on a tour of neutrophils, the most abundant leukocytes in mammals, including tethers and slings, neutrophil rolling, and neutrophil nets.
Immune - Vincent Racaniello
2y ago
Immune explains how aging influences chronic outcomes of respiratory viral infection through regulation of the alveolar macrophage compartment and type 2 inflammatory responses to viruses.
Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker
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Download Immune 54 (97 MB .mp3, 80 min)
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Age-dependent reduction in asthmatic pathology (J Immune)
Time stamps by Jolene. Thanks!
Music by Steve Neal.
Imm ..read more
Immune - Vincent Racaniello
2y ago
Immune reveals that marginal zone B cells steal complexes of MHC and complement C3 from dendritic cells for antigen presentation to T cells.
Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker
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Download Immune 53 (97 MB .mp3, 80 min)
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Trogocytosis in Immune 18
B cells steal from dendritic cells (Science)
Time stamps by Jolene. Thanks!
Music by Steve Neal.
Immune logo image by Blausen Medical
Send your immu ..read more
Immune - Vincent Racaniello
3y ago
Gabriel Victora joins Immune to review how high affinity antibodies are produced in the germinal centers of secondary lymphoid tissues.
Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker
Guest: Gabriel Victora
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Download Immune 52 (76 MB .mp3, 63 min)
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Concerto in B (TWiV 161)
Visualizing antibody affinity maturation (Science)
Restricted B cell clonality after boosting (Cell)
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Immune - Vincent Racaniello
3y ago
Nikhil Joshi joins Immune to discuss the creation of NINJA mice that synthesize neoantigens to enable the study of endogenous antigen-specific naïve T cell responses in disease and infection.
Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker
Guest: Nikhil Joshi
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Download Immune 51 (76 MB .mp3, 63 min)
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Creation of NINJA mice (Nature Biotech)
Time stamps by Jolene. Thanks!
Music by Steve Neal.
Im ..read more
Immune - Vincent Racaniello
3y ago
Immune reviews evidence that toll-like receptor 9 on the surface of red blood cells binds DNA, leading to uptake by macrophages and innate immune activation.
Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker
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Download Immune 50 (57 MB .mp3, 94 min)
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DNA binding to TLR9 on red blood cells (Sci Transl Med)
Time stamps by Jolene. Thanks!
Music by Steve Neal.
Immune logo image by Blausen Medical
Se ..read more
Immune - Vincent Racaniello
3y ago
Keke Fairfax joins Immune to discuss the work from her laboratory on understanding how maternal schistosomiasis impairs IL-4 production and B cell expansion in offspring, and modulation of macrophage immunometabolism by helminths.
Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker
Guest: Keke Fairfax
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Download Immune 49 (57 MB .mp3, 94 min)
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Maternal schistosomiasis impairs offspring immunity (PloS ..read more
Immune - Vincent Racaniello
3y ago
Tim Hand joins Immune to discuss the work from his laboratory showing that environmental enteric dysfunction, a disease caused by chronic malnutrition and infection, and which is associated with reduced growth and oral vaccine failure, is controlled by an increase in intestinal regulatory T cells.
Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker
Guest: Timothy Hand
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Download Immune 48 (45 MB .mp3, 75 min)
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Immune - Vincent Racaniello
3y ago
The immune professors discuss neutrophil extracellular traps, and how IgA-virus immune complexes potentiate this process through Fc receptors on neutrophils.
Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker
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Download Immune 47 (43 MB .mp3, 71 min)
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Antiviral IgA potentiates NETosis (PNAS)
Letters read on Immune 47
Time stamps by Jolene. Thanks!
Music by Steve Neal.
Immune logo image by Blausen ..read more
Immune - Vincent Racaniello
3y ago
Immune explore the observation that bat cells display dampened STING-dependent interferon activation, suggesting why bats might have a unique capacity to harbor many viruses.
Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker
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Download Immune 46 (50 MB .mp3, 84 min)
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Dampened STING in bats (Cell Host Micr)
Lessons from bat defenses (Nature)
Bat immune systems (Front Immune)
Bats protected from gen ..read more
Immune - Vincent Racaniello
3y ago
On this episode of Immune, we answer listener questions about CAR-Macs, complement and COVID-19, sleep and the immune system, caving and the immune system, germinal centers, COVID-19 vaccines and much more.
Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker
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Download Immune 45 (50 MB .mp3, 84 min)
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Links for this episode
Letters read on Immune 45
Time stamps by Jolene. Thanks!
Music by Steve Neal.
Immune logo image by B ..read more