The Journal of Physiology, EarlyView ..read more

The Journal of Physiology, Volume 602, Issue 9, Page 1853-1854, 1 May 2024 ..read more

Abstract figure legend Following chronic intermittent hypoxia (CIH), the augmentation in neuronal activity and synaptic transmission by oxytocin (OT) and corticotropin-releasing hormone (CRH) within the nucleus tractus solitarii (nTS) was enhanced compared to normoxia exposure. nTS slices were analysed to assess neuronal electrophysiological properties and calcium (Ca2+) influx. CIH exaggerated nTS discharge, excitatory synaptic currents and Ca2+ influx specifically in response to CRH, with further amplification observed upon the addition of OT. CIH also increased the tonic functional contrib ..read more

The Journal of Physiology, EarlyView ..read more

Abstract figure legend The remote effects of left M1 tbTUS on the contralateral right M1 was investigated in the present study, with the measurement of right M1 excitability, interhemispheric inhibition (IHI), and intracortical circuits. The results showed that left M1 tbTUS decreased right M1 excitability, decreased short interval IHI from left-to-right hemisphere and increased right M1 intracortical facilitation (ICF). These findings provide novel insights into the remote modulatory effect of tbTUS, which should be considered in the development of tbTUS for the treatment of neurological and ..read more

The Journal of Physiology, EarlyView ..read more

The Journal of Physiology, EarlyView ..read more

Abstract figure legend Fast skeletal muscle is optimized for rapid, burst-like contractions that can be switched ON and OFF quickly while the slow cardiac muscle in large mammalian hearts adopts a more finely tuned graded response to allow for their substantial functional reserve to be regulated by various inotropic interventions. Abstract There is a growing appreciation that regulation of muscle contraction requires both thin filament and thick filament activation in order to fully activate the sarcomere. The prevailing mechano-sensing model for thick filament activation was derived from ex ..read more

Abstract figure legend We investigated the regional (leg, arm and head) and systemic haemodynamics during passive single-leg, two-leg and whole-body hyperthermia to test the hypothesis that the increase in cardiac output (Q̇$\dot Q$) with hyperthermia is closely related to elevations in peripheral haemodynamics rather than changes in central haemodynamic forces and factors. Single-leg, two-leg, and whole-body hyperthermia induced graded increases in Q̇$\dot Q$, tightly associated with increased peripheral (limbs and head) blood flow, vascular conductance (VC), blood velocity (BV) and kinetic ..read more

Abstract figure legend Cartoon rendition of properties of human GP neurons from non-AF (left) and AF (right) patients. In AF patients, there are significantly fewer cholinergic neurons, more noradrenergic neurons, and fewer dual-phenotype neurons compared to GP neurons from non-AF patients. Cellular electrophysiological studies show GP neurons also fire action potentials for a longer time duration in AF patients compared to non-AF patients. Together these data show both functional and structural differences occur in GP neurons from non-AF vs. AF patients, highlighting that cellular plasticity ..read more