H3K27ac acts as a molecular switch for doxorubicin-induced activation of cardiotoxic genes
Clinical Epigenetics
by Yu Hong, Xinlan Li, Jia Li, Qiuyi He, Manbing Huang, Yubo Tang, Xiao Chen, Jie Chen, Ke-Jing Tang and Chao Wei
3d ago
Doxorubicin (Dox) is an effective chemotherapeutic drug for various cancers, but its clinical application is limited by severe cardiotoxicity. Dox treatment can transcriptionally activate multiple cardiotoxici ..read more
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Effects of improved on-farm crop storage on DNA methylation of mothers and their infants: evidence from a randomized controlled trial in Kenya
Clinical Epigenetics
by Heike Eichenauer, Susanne Fischer, Elena Gardini, Simon Onsongo and Ulrike Ehlert
1w ago
Stress during pregnancy can lead to adverse maternal and infant health outcomes through epigenetic changes in the hypothalamic–pituitary–adrenal axis. Among farmers in low-income countries, one important stres ..read more
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DNA methylation profile of inflammatory breast cancer and its impact on prognosis and outcome
Clinical Epigenetics
by Flavia Lima Costa Faldoni, Daniela Bizinelli, Cristiano Pádua Souza, Iara Viana Vidigal Santana, Márcia Maria Chiquitelli Marques, Claudia Aparecida Rainho, Fabio Albuquerque Marchi and Silvia Regina Rogatto
1w ago
Inflammatory breast cancer (IBC) is a rare disease characterized by rapid progression, early metastasis, and a high mortality rate ..read more
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A systematic review on the contribution of DNA methylation to hearing loss
Clinical Epigenetics
by Vibha Patil, Patricia Perez-Carpena and Jose A. Lopez-Escamez
2w ago
DNA methylation may have a regulatory role in monogenic sensorineural hearing loss and complex, polygenic phenotypic forms of hearing loss, including age-related hearing impairment or Meniere disease. The purp ..read more
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The chromatin accessibility and transcriptomic landscape of the aging mice cochlea and the identification of potential functional super-enhancers in age-related hearing loss
Clinical Epigenetics
by Chanyuan Zhang, Ting Yang, Xiaoqin Luo, Xiaoqing Zhou, Menglong Feng and Wei Yuan
2w ago
Presbycusis, also referred to as age-related hearing loss (ARHL), is a condition that results from the cumulative effects of aging on an individual's auditory capabilities. Given the limited understanding of e ..read more
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Respiratory infection- and asthma-prone, low vaccine responder children demonstrate distinct mononuclear cell DNA methylation pathways
Clinical Epigenetics
by David Martino, Nikki Schultz, Ravinder Kaur, Simon D. van Haren, Nina Kresoje, Annmarie Hoch, Joann Diray-Arce, Jessica Lasky Su, Ofer Levy and Michael Pichichero
2w ago
Infants with frequent viral and bacterial respiratory infections exhibit compromised immunity to routine immunizations. They are also more likely to develop chronic respiratory diseases in later childhood. Thi ..read more
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Epigenetic scores derived in saliva are associated with gestational age at birth
Clinical Epigenetics
by Katie Mckinnon, Eleanor L. S. Conole, Kadi Vaher, Robert F. Hillary, Danni A. Gadd, Justyna Binkowska, Gemma Sullivan, Anna J. Stevenson, Amy Corrigan, Lee Murphy, Heather C. Whalley, Hilary Richardson, Riccardo E. Marioni, Simon R. Cox and James P. Boardman
2w ago
Epigenetic scores (EpiScores), reflecting DNA methylation (DNAm)-based surrogates for complex traits, have been developed for multiple circulating proteins. EpiScores for pro-inflammatory proteins, such as C-r ..read more
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Epigenetic regulation of major histocompatibility complexes in gastrointestinal malignancies and the potential for clinical interception
Clinical Epigenetics
by Jorge Enrique Tovar Perez, Shilan Zhang, William Hodgeman, Sabeeta Kapoor, Praveen Rajendran, Koichi S. Kobayashi and Roderick H. Dashwood
2w ago
Gastrointestinal malignancies encompass a diverse group of cancers that pose significant challenges to global health. The major histocompatibility complex (MHC) plays a pivotal role in immune surveillance, orc ..read more
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Methylome analysis in girls with idiopathic central precocious puberty
Clinical Epigenetics
by Stefania Palumbo, Domenico Palumbo, Grazia Cirillo, Giorgio Giurato, Francesca Aiello, Emanuele Miraglia del Giudice and Anna Grandone
3w ago
Genetic and environmental factors are implicated in many developmental processes. Recent evidence, however, has suggested that epigenetic changes may also influence the onset of puberty or the susceptibility t ..read more
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Estrogen-mediated DNMT1 and DNMT3A recruitment by EZH2 silences miR-570-3p that contributes to papillary thyroid malignancy through DPP4
Clinical Epigenetics
by Xiarong Hu, Qingyao Ye, HuanQuan Lu, Zhiming Wu, Siyuan Chen and Ruinian Zheng
1M ago
Papillary thyroid carcinoma (PTC) is a common endocrine malignancy. Studies have indicated that estrogen can regulate the expression of miRNAs in numerous malignancies. MiR-570-3p has been shown to have a regu ..read more
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