Synergistic Epigenetic Medications Show Promise in Colorectal Cancer and Beyond
What is Epigenetics?
by Natalie Crowley
6d ago
Colorectal cancer ranks as the second leading cause of cancer-related deaths in the United States, presenting a multifaceted challenge influenced by both genetic and environmental factors. Despite advancements in treatment, there remains a pressing need for innovative therapies, particularly as cases rise among younger adults and at advanced disease stages. One promising approach lies in epigenetics, the study of chemical modifications on DNA and its packaging proteins that influence gene expression without altering the DNA sequence. Cancer cells often display abnormal epigenetic patterns, ma ..read more
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Epigenetic Insights for Targeting Alzheimer’s Disease
What is Epigenetics?
by Natalie Crowley
1M ago
The recent FDA approval of Donanemab has sparked celebration within the Alzheimer’s research community, offering significant hope by slowing cognitive decline in some patients. However, it is clear to scientists that Donanemab is not a cure, and the quest to truly halt or reverse Alzheimer’s disease (AD) remains ongoing. Donanemab works by targeting amyloid beta (Aβ) plaques, a hallmark protein buildup in AD’s pathology. While clearing these plaques marks a critical step, it may not address the root cause of the disease. This is where the study of epigenetics helps, providing insights into ho ..read more
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Artificial Intelligence and GPT-Powered Skin Epigenetics: Applications in Personalized Skincare
What is Epigenetics?
by WhatIsEpigenetics
2M ago
Epigenetics refers to the modifications of DNA by adding chemical tags, which switch genes on and off without altering the underlying DNA sequence. This process, known as epigenetic regulation, occurs in every person and changes throughout their life. Notably, skin aging, health, and beauty are influenced by environmental interactions, and these changes are governed by epigenetics rather than genes alone. Thus, epigenetic regulation is a pivotal factor in controlling one’s skin aging, health, and beauty status, offering dynamic and reversible skin changes. Building on this scientific foundati ..read more
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Researchers Unlock the Mysteries of Epigenetic Inheritance
What is Epigenetics?
by Natalie Crowley
2M ago
Understanding trait inheritance is crucial for unraveling the complexities of life’s blueprint and how it shapes the world around us. It provides insights into the transmission of characteristics from one generation to the next, shedding light on the mechanisms that underpin biological diversity and evolution. In a groundbreaking study featured in the journal Nature, researchers have unveiled the hidden secrets of how our DNA replication machinery meticulously safeguards and transfers epigenetic information during cell division. Led by Professor Yuanliang Zhai at the School of Biological Scie ..read more
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Common Flame Retardant Alters the Epigenome of Aquatic Organisms
What is Epigenetics?
by Natalie Crowley
3M ago
Flame retardants are ubiquitous chemicals added to numerous consumer products to prevent the spread of fire. While they are essential in enhancing fire safety, their widespread use has raised concerns about their environmental and health impacts. One such flame retardant, triphenyl phosphate (TPhP), has gained popularity as an alternative to previously restricted compounds. However, recent studies suggest that TPhP may pose risks to both aquatic ecosystems and human health through its potential to disrupt endocrine systems and alter gene expression. In a study investigating the epigenetic eff ..read more
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Epigenetic Changes in Immune Cells Linked to Alzheimer’s Disease
What is Epigenetics?
by Natalie Crowley
3M ago
Alzheimer’s disease is a degenerative brain disorder that impacts millions globally. While the exact cause of the disease is still unknown, a recent study by Northwestern University (NU) has shed light on the potential role of epigenetic modifications in the immune system of Alzheimer’s patients. The study found that Alzheimer’s patients experience epigenetic changes in their blood’s immune system, which could be influenced by environmental factors, past infections, and lifestyle behaviors. These findings could pave the way for the development of new therapeutic targets for modulating the per ..read more
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DNA Methylation’s Role in Preventing Cleft Lip and Palate
What is Epigenetics?
by Natalie Crowley
4M ago
Cleft lip and palate stand out as the most prevalent craniofacial birth anomalies worldwide, affecting approximately 1 in 700 newborns. Despite extensive research spanning decades, the precise etiology of most cases remains elusive, as does effective preventive measures. Understanding the causes of this abnormality has mainly focused on genetic factors, revealing numerous risk loci along the DNA, although direct causative variants are rare. Therefore, it is thought that this defect arises from a mix of genetic and environmental factors. Yet, the precise environmental triggers and mechanisms r ..read more
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Scientists Use Machine Learning to Develop an Epigenetic Clock for Predicting Biological Age Better
What is Epigenetics?
by Natalie Crowley
5M ago
In the quest to unravel the mysteries of aging, scientists have long turned to our genetic code for answers. While machine learning models have offered insights into predicting biological age, understanding the causal factors behind aging has yet to be discovered. However, a groundbreaking study has now shed light on the hidden workings of aging by delving deep into the intricate realm of epigenetics. Scientists at Brigham and Women’s Hospital, part of Mass General Brigham, have developed an innovative “epigenetic clock” to help understand on what drives aging. Based on analyzing DNA met ..read more
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Type 2 Diabetes Linked with Epigenetic Changes
What is Epigenetics?
by Elizabeth Fontanilles
5M ago
Diabetes is a widespread health issue that affects millions of people worldwide. The disease is complex and can develop due to a combination of genetic and lifestyle factors. Given its increasing prevalence, scientists worldwide are investigating the underlying genetic complexities and epigenetic factors of diabetes in more detail. One question that researchers are interested in is whether epigenetic changes cause type 2 diabetes or if the changes occur only after a person has become ill. A new study by Lund University’s researchers now provides increased support for the idea that epigenetic ..read more
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Positive Parenting May Reverse Epigenetic Age in Children Affected by Adversity
What is Epigenetics?
by Natalie Crowley
6M ago
Growing up amid adversity, encompassing elements like poverty, child maltreatment, and community violence, not only poses a significant risk for psychopathology and lifelong health challenges but also has been shown to accelerate the biological or epigenetic aging process in children. However, a new study featuring research conducted in the lab of Professor Justin Parent, an assistant professor of psychology at the University of Rhode Island, has introduced a promising prospect. Positive parenting interventions might hold the key to slowing down or even reversing the accelerated biological ag ..read more
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