Disseminated Cryptococcosis
The New England Journal of Medicine | Nephrology
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2y ago
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AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis
The New England Journal of Medicine | Nephrology
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2y ago
Peritoneal dialysis is the leading form of home-based dialysis therapy for patients with kidney failure. The advantages of peritoneal dialysis, as compared with hemodialysis, include ease of use, a decreased need for trained medical staff and technical support, and accessibility in remote and rural ..read more
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Aquaporin-1 Expression and Ultrafiltration of the Peritoneal Membrane
The New England Journal of Medicine | Nephrology
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2y ago
Peritoneal dialysis in adults involves diffusion and osmosis through a peritoneal membrane, measuring 1 m2, that is highly vascularized (flow rate, 100 to 150 ml per minute) and has a total available capillary surface area of approximately 2 m2. For decades, glucose has been used as the ..read more
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Case 32-2021: A 14-Year-Old Girl with Swelling of the Jaw and Hypercalcemia
The New England Journal of Medicine | Nephrology
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2y ago
Presentation of Case. Dr. Austin Be (Surgery): A 14-year-old girl was admitted to this hospital because of swelling of the left jaw. The patient had been well until 6 weeks before this admission, when she noticed a lump in the left lower jaw; there was no pain, tenderness, or discomfort in the jaw ..read more
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Time to Eliminate Health Care Disparities in the Estimation of Kidney Function
The New England Journal of Medicine | Nephrology
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2y ago
In the wake of the racial reckoning since the spring of 2020 in the United States, efforts have emerged to identify hidden structural determinants of systemic racism in medicine. Such efforts have led to examination of traditional medical algorithms that incorporate race modifiers and may have led ..read more
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Race, Genetic Ancestry, and Estimating Kidney Function in CKD
The New England Journal of Medicine | Nephrology
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2y ago
Consideration of race in clinical decision making has recently come under much scrutiny and criticism. In particular, the use of indicators for Black race in equations that are widely used to estimate the glomerular filtration rate (GFR) from the serum creatinine level has been questioned. Adults ..read more
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New Creatinine- and Cystatin C–Based Equations to Estimate GFR without Race
The New England Journal of Medicine | Nephrology
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2y ago
The glomerular filtration rate (GFR) is generally estimated from serum concentrations of endogenous filtration markers such as creatinine or cystatin C. During the past two decades, automated clinical laboratory reporting of GFR estimated with the use of creatinine (eGFRcr) has become widespread ..read more
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Cardiovascular and Renal Outcomes with Efpeglenatide in Type 2 Diabetes
The New England Journal of Medicine | Nephrology
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2y ago
The incidence of adverse cardiovascular events among persons with diabetes is triple that among persons without diabetes; the incidence of adverse renal events is also high among persons with diabetes. The incidence of adverse cardiovascular events rises with increasing duration of diabetes ..read more
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Trial of Intensive Blood-Pressure Control in Older Patients with Hypertension
The New England Journal of Medicine | Nephrology
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2y ago
Hypertension is a common risk factor for death from cardiovascular causes worldwide and in China. With aging of the population, determination of the treatment target for systolic blood pressure in older patients with hypertension has become a focus of research. Current guideline-based ..read more
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Moving the Goalposts for Blood Pressure — Time to Act
The New England Journal of Medicine | Nephrology
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2y ago
We often lament the lack of confirmatory studies that can either reassure us all that the previous evidence for a trialed intervention is robust or indicate that the evidence is questionable. Zhang and colleagues have conducted such a study — the STEP trial — which in essence investigates the ..read more
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