Ajax Jossy, N Kaviyapriya, Nirupama Kasturi, J Sree Rekha Indian Journal of Pathology and Microbiology 2023 66(3):608-610 A middle-aged woman presented with a slowly enlarging mass in the right superotemporal orbit and ptosis. The patient had an elevated erythrocyte sedimentation rate, and incisional biopsy showed granulomatous inflammation with Langhan's giant cells suggestive of a tubercular etiology. Tuberculin skin test was negative. The patient responded well to anti-tuberculous therapy. Tubercular dacryoadenitis is a rare presentation of a lacrimal gland mass ..read more

Chhabra Seema, Dhir Varun, Dhooria Sahajal, Walker R Minz Indian Journal of Pathology and Microbiology 2023 66(3):676-677 ..read more

Tarang Patel, Priyanka Aswal, Ashish Jakhetiya, Virendrakumar Meena, Arun Pandey Indian Journal of Pathology and Microbiology 2023 66(3):601-604 Uterine leiomyosarcoma (ULMS) is a rare malignancy arising from the myometrial smooth muscle wall, and cardiac metastases are extremely rare. Metastasis to the heart is a very unusual finding, and atrial metastasis is even rarer. Here, we report a case of a 45 year old woman who presented with dyspnea and pleural effusion and had a significant history of hysterectomy done for ULMS. Magnetic resonance imaging revealed a left atrial mass, which was re ..read more

Jae-Ho Lee, Ji-An Uh, Joong-Ho Kim, Soo-Kyung Lee, Myoung-Shin Kim, Un-Ha Lee Indian Journal of Pathology and Microbiology 2023 66(3):659-660 ..read more

Manish Raturi, Bhawana Adhikari, Aastha Kalra, Mansi Kala, Anuradha Kusum Indian Journal of Pathology and Microbiology 2023 66(3):669-671 ..read more

Pavithra Ayyanar, Mukund N Sable, Amit K Adhya, Manoj K Das, Madhabananda Kar, Pritinanda Mishra Indian Journal of Pathology and Microbiology 2023 66(3):627-631 Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy. Extensive rhabdoid morphology in ACC has been described recently in very few cases. The proportion of rhabdoid morphology and the role of SMARCB1/ INI1 expression in these tumor cells to diagnose the specific variant is not described in the literature. We reviewed the clinicopathological features of nine cases of adrenocortical neoplasm. Out of which, three cases of ..read more

Ali Rıza Guvercin, Beyhan Guvercin, Emel Çakır, Uğur Yazar Indian Journal of Pathology and Microbiology 2023 66(3):644-647 Erdheim–Chester Disease (ECD) is a rare non-Langerhans form of systemic histiocytosis of unknown etiology with multiple organ involvement. It most commonly affects the long bones, lungs, heart, retroperitoneum, eyes, and kidneys and less commonly the brain and spinal cord. Although there are very few cases of supratentorial ECD mimicking intracranial meningioma reported in literature, to the best of our knowledge, there are n ..read more

Zuhal Gucin, Nur Buyukpinarbasili, Melin Ozgun Gecer, Yeliz Emine Ersoy, Haci Mehmet Turk, Seyma Yildiz, Direnc Ozlem Aksoy Indian Journal of Pathology and Microbiology 2023 66(3):495-501 Aim: This study aims to investigate potential associations between the stem cell population and the degree of tumor regression in breast carcinomas treated with neoadjuvant therapy. Settings and Design: The study included 92 patients with breast carcinoma who received neoadjuvant therapy. Tumor regression was defined based on Miller and Payne grading system. Patients with grade 1 or 2 regression on a 5-poin ..read more

Afraa Mamoori, Zena Hasan Sahib, Haider Alkafaji Indian Journal of Pathology and Microbiology 2023 66(3):472-477 Introduction: miR-125a-3p could have a role in gastric cancer by targeting HER2. This study aimed to investigate the expression pattern of miR-125a-3p, identify the expression level of its target gene in gastric carcinoma, and test its effect in HER-2 positive gastric carcinoma cells. Materials and Methods: The levels of miR-125a-3p in both cancer and noncancer tissues were measured by using Quantitative real-time polymerase chain in 70 gastric carcinomas. Immunohistochemical stud ..read more

Xu Han, Ting Yan, Lina Wang, Bin He, Huaxu Yu Indian Journal of Pathology and Microbiology 2023 66(3):478-487 Objective: This article aims to study the effect of phosphate and tension homolog deleted on chromosome ten (PTEN) knockdown on colon cancer progression and macrophage polarization in the cancer environment. Materials and Methods and Results: The expression of PTEN in colon cancer tissues and colon cancer cells was significantly lower than in precancerous tissues or CCD-18Co cells, and the decrease was most evident in SW620 cells. The expressions of phosphate (p)-p38, c-Jun N-termina ..read more