Hi, I'm interested about getting WGS to know more about myself and my health. My life goal is to improve my physical and mental health as well as knowing myself better. I have adhd and asd btw. edit: i also struggle to fall asleep submitted by /u/EmptyMindTM [visit reddit] [comments ..read more

submitted by /u/gwern [visit reddit] [comments ..read more

Hello, I was wondering if there are European based labs that offer whole genome sequencing for regular people, so not doctors. If so, which ones and if not, which others do you recommend? I ordered WGS at Nebula Genomics but after 14,5 weeks and like 4 weeks into sequencing stage they just told me that it did not met quality standards. Since shipping is quite expensive to the US and I don't really trust that they will deliver it to me after another few weeks, I'm considering to just take my loss and order it somewhere else instead of getting a new kit from them. submitted by /u/Joymxxx [visi ..read more

Bioinformatics: Python vs Other Languages Many of us think Python is great. In data-rich scientific fields (including Biology), high-level languages like Python and R remain widely used both for method development and data analysis. On numeric data, array programming in Python is fast – thanks to NumPy. However, operations on non-numeric data were slow – the reason why many of the widely used Bioinformatics tools were written in low-level languages. What is not so great about Bioinformatic tools written in low-level languages Don’t get me wrong. Any programming language as a tool that serves ..read more

So, I’m having trouble understanding why you would just classify your reads and not try to assemble them into contigs to use BLAST afterward. Wouldn’t this make your assumptions more accurate? I found an article talking about this difference in virus samples, but I can’t find it right now. submitted by /u/Soft_Ad_4509 [visit reddit] [comments ..read more

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submitted by /u/gwern [visit reddit] [comments ..read more

submitted by /u/gwern [visit reddit] [comments ..read more

I know that epigenetics doesn’t directly alter the DNA sequence in humans. But what about indirectly altering it? Such as via certain epigenetic alterations that makes a human susceptible to get a certain disease (such as a form of cancer). Can epigenetic changes indirect genetic changes? submitted by /u/Seven1s [visit reddit] [comments ..read more

I'm an undergad student and I'm struggling to figure out how does gc rich regions matter. Maybe it's a stupid question but I really need help with this. I thought it was because of the three hydrogen bonds which provides stability but then found out that stability comes from base stacking. So what exactly is the role of GC rich content? submitted by /u/thickk__jack [visit reddit] [comments ..read more